Igor Makhlin, MD
Medical Oncology
Accepting new patients
Sees patients age 18 and up
Rena Rowan Breast Center
View 1 additional location
Penn Medicine Provider

About me

  • Assistant Professor of Clinical Medicine (Hematology-Oncology)

Education and training

  • Medical School: Geisinger Commonwealth School of Medicine
  • Residency: Johns Hopkins Hospital
  • Fellowship: University of Pennsylvania Health System

What my patients think about me

Average Rating

708 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

November 2025
he was excellent
November 2025
attentive, caring, knowledgeable
October 2025
i trusted him
October 2025
we feel very lucky to have him as our caretaker-he is very current on all info and willing to hear what we have to say on the health topics and questions of concern. he does his homework!

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
Dr. Makhlin is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

DeMichele A, Clark AS, Shea E, Bayne LJ, Sterner CJ, Rohn K, Dwyer S, Pan TC, Nivar I, Chen Y, Wileyto P, Berry LR, Deluca S, Savage J, Makhlin I, Pant DK, Martin H, Egunsola A, Mears N, Goodspeed BL, Chislock EM, Graves J, Wang J, Shih N, Belka GK, Berry D, Nayak A, Feldman M, Chodosh LA. Targeting dormant tumor cells to prevent recurrent breast cancer: a randomized phase 2 trial , Nat Med: 2025


Jacob B. Reibel, Christopher A. D’Avella, Igor Makhlin2, Mengru Wang, Maneet Kaur, Yunzhi Qian, Rebecca L. Maniago, Ivy P. Altomare, Lawrence N. Shulman Guideline concordant osimertinib and durvalumab in two US non-small cell lung cancer cohorts. , ASCO Quality Care Symposium: 2025


Igor Makhlin Dissecting Biologic Risk Using Genomic Assays - Implications for Extended Endocrine Therapy and Beyond , JAMA Network Open - In Press: 2024


Makhlin I, Fallowfield L, Henry NL, Burstein HJ, Somerfield MR, DeMichele A. Targeted Therapies, Sequencing Strategies, and Beyond in Metastatic Hormone Receptor-Positive Breast Cancer: ASCO Guideline Clinical Insights , JCO Oncol Pract: 2024


Makhlin I, Demissei BG, D'Agostino R, Hundley WG, Baleanu-Gogonea C, Wilcox NS, Chen A, Smith AM, O'Connell NS, Januzzi JL, Lesser GJ, Scherrer-Crosbie M, Ibáñez B, Tang WHW, Ky B. Statins Do Not Significantly Affect Oxidative Nitrosative Stress Biomarkers in the PREVENT Randomized Clinical Trial , Clin Cancer Res, 30: 2024,2370-2376


Debashish Tripathy, Kashif Ali, Laila Agrawal, Sami M. Ali, Sibel Blau, Margaret Block, Michael A. Danso, Denise Yardley, Jay Andersen, Adrienne Gropper Waks, Priya Jayachandran, Igor Makhlin, Petros Nikolinakos, Richard Zuniga, Joyce O'Shaughnessy, Sandra Aung, Janice M. Lu, Kevin Kalinsky, William John Gradishar, Hope S. Rugo ACE-BREAST-03: A phase 2 trial evaluating ARX788, an anti-HER2 antibody drug conjugate (ADC), for the treatment of HER2+ metastatic breast cancer (mBC) in patients who have been previously treated with trastuzumab deruxtecan (T-DXd) , Journal of Clinical Oncology, 42(16_suppl): 2024


A. DeMichele A.S. Clark L. Bayne K. Rohn I. Nivar P. Wileyto L. Berry S. DeLuca J. Savage I. Makhlin T.C. Pan J. Graves G. Belka J. Wang N. Shih D. Berry A. Nayak M. Feldman L. Chodosh 244MO A phase II trial targeting disseminated dormant tumor cells with hydroxychloroquine, everolimus or the combination to prevent recurrent breast cancer (“CLEVER”) , ESMO Abstract, 34: 2023,S281


Fradley MG, Nguyen NHK, Madnick D, Chen Y, DeMichele A, Makhlin I, Dent S, Lefebvre B, Carver J, Upshaw JN, DeRemer D, Ky B, Guha A, Gong Y. Adverse Cardiovascular Events Associated With Cyclin-Dependent Kinase 4/6 Inhibitors in Patients With Metastatic Breast Cancer , J Am Heart Assoc, 12: 2023,e029361


Chen S, Paul MR, Sterner CJ, Belka GK, Wang D, Xu P, Sreekumar A, Pan TC, Pant DK, Makhlin I, DeMichele A, Mesaros C, Chodosh LA. PAQR8 promotes breast cancer recurrence and confers resistance to multiple therapies , Breast Cancer Res, 25(1): 2023,1


Kaufmann T, Chang P, Rosenberg SM, Frank E, Hobbs B, Bayne LJ, Nivar I, Goodspeed BL, Rohn KM, Kugler EM, Fox K, Domchek SM, Bradbury A, Shah PD, Knollman h, Jankowitz RC, Makhlin I, Clark AS, Chodosh LA, DeMichele A, Goodfellow KE. P5-08-01: Pilot study of a patient-reported outcome (PRO) measurement strategy to determine impact of screening for minimal residual disease (MRD) in high-risk breast cancer survivors , San Antonio Breast Cancer Symposium 2022, San Antonio, TX.: 2022


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