Penn Medicine Provider
Infectious Diseases
Harvey Rubin, MD, PhD
4.9
(59)
Sees patients age 18 and up
MacGregor Infection Medicine and Travel Program
Make an appointmentCall 800-789-7366

About me

  • Professor of Medicine (Infectious Diseases)

&Dr. Rubin is a Professor of Medicine at the University of Pennsylvania with secondary appointments as Professor in the Department of Biochemistry and Biophysics, and as Professor of Computer and Information Sciences at the University of Pennsylvania School of Engineering and Applied Sciences. His research in infectious diseases has been funded by the NIH, NSF, DARPA, the Global Alliance for TB Drug Discovery, and the Department of Defense.  In addition to his work on the basic biology of bacterial pathogenesis, he has extended the investigations to mathematical modeling of complex biological systems. His research has resulted in more than 100 peer-reviewed papers chapters or reviews. His clinical practice is limited to infectious diseases and he sees patients at the Hospital of the University of Pennsylvania. 

Dr. Rubin has served on a number of national and international scientific review panels including the NIH, NSF, NASA Intelligent Systems Program, DARPA, and The Medical Research Council, South Africa. He was a member of the United States National Science Advisory Board for Biosecurity (NSABB), and the Department of Defense/National Academy of Sciences Biological Cooperative Threat Reduction Program.  He has published and lectured extensively on policy issues that relate to infectious diseases

Dr. Rubin is the founder of Energize the Chain, a non-profit organization that ensures the delivery of vaccines to people in the most remote regions of the world by utilizing power and connectivity in the private sector, such as that available at cell tower sites to power the refrigeration systems that are necessary to keep vaccines at the proper temperature.

Education and training

  • Medical School: Columbia University
  • Residency: Massachusetts General Hospital/Brigham and Women’s Hospital

What my patients think about me

Average Rating
4.9

59 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

May 2025
5.0
5.0
dr. rubin is very personable.
April 2025
5.0
5.0
interested in case and dx
March 2025
5.0
5.0
dr rubin is clearly an expert in his field and gave his undivided attention and expertise during my appointment.
March 2025
5.0
5.0
dr. rubin is very amiable and informative.

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: On the medical staff, but does not have privileges to treat patients in the hospital.
  • Penn Medicine Rittenhouse Long-Term Acute Care Hospital: Has privileges to treat patients in the hospital.
Dr. Rubin is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Abhiraman B, Fotis R, Eskin L, Rubin H. Fault Detection for Vaccine Refrigeration via Convolutional Neural Networks Trained on Simulated Datasets. , International Journal of Refrigeration. Volume 149, May 2023, Pages 274-285.: 2023

Kim .J, Xin Chen X, Nikpey. H, Rubin. H, Bidokhti SS, Sarkar S. Tracing and testing multiple generations of contacts to COVID-19 cases: cost-benefit trade-offs. , R Soc Open Sci . 2022 Oct 12;9(10):211927. doi: 10.1098/rsos.211927. eCollection 2022 Oct.: 2022

Chowdhury SR, Rafayat S, Yasir MT, Hossain S, Shetty S, Tahsin S, Rubin H, Rahaman A. Vaccine Storage and Distribution in Rural Bangladesh. , International Journal of Medicine and Public Health,2022,12,2,56-64. DOI:10.5530/ijmedph.2022.2.12.: 2022

Ali RN, Rubin H, Sarkar S Countering the potential re-emergence of a deadly infectious disease—Information warfare, identifying strategic threats, launching countermeasures.: , PLoS ONE 16(8): 2021

Dutta NK, Klinkenberg LG, Vazquez M-J, Segura-Carro D, Colmenarejo G, Ramon F, Rodriguez-Miquel B, Mata-Cantero L, Porras-De Francisco E, Chuang Y-M, Rubin H, Lee JJ, Eoh H, Bader JS, Perez-Herran E, Mendoza-Losana A, Karakousis PC Inhibiting the stringent response blocks entry into quiescence and reduces persistence , Science advances, 5(3): 2019,eaav2104

Harbut MB, Yang B, Liu R, Yano T, Vilchèze C, Cheng B, Lockner J, Guo H, Yu C, Franzblau SG, Petrassi HM, Jacobs WR, Rubin H, Chatterjee AK, Wang F Small Molecules Targeting Mycobacterium tuberculosis Type II NADH Dehydrogenase Exhibit Antimycobacterial Activity , Angewandte Chemie (International ed. in English), 57(13): 2018,3478-3482

Ogura M, Wakaiki M, Rubin H, Preciado VM Delayed bet-hedging resilience strategies under environmental fluctuations , Physical Review E, 95(5-1): 2017,052404

Tantry SJ, Markad SD, Shinde V, Bhat J, Balakrishnan G, Gupta AK, Ambady A, Raichurkar A, Kedari C, Sharma S, Mudugal NV, Narayan A, Naveen KCN, Nanduri R, Bharath S, Reddy J, Panduga V, Prabhakar KR, Kandaswamy K, Saralaya R, Kaur P, Dinesh N, Guptha S, Rich K, Murray D, Plant H, Preston M, Ashton H, Plant D, Walsh J, Alcock P, Naylor K, Collier M, Whiteaker J, McLaughlin RE, Mallya M, Panda M, Rudrapatna S, Ramachandran V, Shandil R, Sambandamurthy VK, Mdluli K, Cooper CB, Rubin H, Yano T, Iyer P, Narayanan S, Kavanagh S, Mukherjee K, Balasubramanian V, Hosagrahara VP, Solapure S, Ravishankar S, Hameed PS Discovery of Imidazo[1,2-a]pyridine Ethers and Squaramides as Selective and Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthesis , J Med Chem, 60(4): 2017,1379-1399

Chuang YM, Dutta NK, Hung CF, Wu TC, Rubin H, Karakousis PC The stringent response factors PPX1 and PPK2 play an important role in Mycobacterium tuberculosis metabolism, biofilm formation, and sensitivity to isoniazid in vivo , Antimicrob Agents Chemother: 2016,pii: AAC.01139-16.

Chuang YM, Bandyopadhyay N, Rifat D, Rubin H, Bader JS, Karakousis PC. Deficiency of the novel exopolyphosphatase Rv1026/PPX2 leads to metabolic downshift and altered cell wall permeability in Mycobacterium tuberculosis , MBio, 6(2): 2015,e02428

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