- Gastrointestinal cancer
- Pancreatic cancer
Gregory L. Beatty, MD, PhD
Medical Oncology
Sees patients age 18 and up
Abramson Cancer Center Perelman 2nd Floor West
Penn Medicine Provider
About me
- Director, Clinical and Translational Research, Penn Pancreatic Cancer Research Center
- Professor of Medicine (Hematology-Oncology)
Dr. Beatty is an internationally renowned expert in cancer immunotherapy and translational research. His focus is on the development of novel immunotherapies for the treatment of cancer including pancreatic cancer and glioblastoma. He has led the development of multiple first-in-human treatment strategies for solid cancers. He is currently Director of Clinical and Translational Research of the Penn Pancreatic Cancer Research Center.
My education and training
- Medical School: University of Pennsylvania School of Medicine
- Residency: University of Pennsylvania Health System
- Fellowship: University of Pennsylvania Health System
Spoken languages
English
English
Insurance accepted
Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.
- Aetna Advantra Cares D-SNP
- Aetna Advantra Credit Value
- Aetna Advantra Eagle HMO
- Aetna Advantra Eagle POS
- Aetna Advantra Premier Plus PPO
- Aetna Advantra Value
- Aetna Advantra Value Plus
- Aetna APCN Plus (Multi-Tier)
- Aetna Better Health Kids (CHIP) - DH Only
- Aetna Flexible Five
- Aetna Freedom Core
- Aetna Gold
- Aetna HMO
- Aetna Philly Prime
- Aetna POS
- Aetna PPO APCN
- Aetna Premier
- Aetna Premier Plus
- Aetna Savings Plus
- Aetna Signature Administrators
- Aetna Student Health Plan PPO
- Aetna Upfront Advantage
- First Health HMO
- First Health POS
- First Health PPO
- Meritain - Aramark (Other)
- Meritain - Aramark (Pennsylvania Premier Medical Plan)
- Americhealth Caritas of PA VIP - LGH Only
- Amerihealth Caritas (Transplant patients only)
- Amerihealth Caritas of PA - LGH Only
- Centivo EPO
- Cigna Healthcare EPO
- Cigna Healthcare HMO
- Cigna Healthcare POS
- Cigna Healthcare PPO
- Claim Watcher (Homestead/ INDECs) Open Access
- Clover Health Choice
- Clover Health Choice Value PPO
- Clover Health Classic HMO
- Clover Health Value
Locations
Penn Medicine hospital privileges
- Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
Qualifications and experience
- Medical Oncology, 2010
- Alligator Biosciences Scientific Advisory Board, International
- American Association For Cancer Research, National
- American Society Of Clinical Oncology, National
- ASCO Gateway Discovery Grant Scientific Review Committee, National
- HiberCell Scientific Advisory Board, International
- Hot Spot Therapeutics Clinical Advisory Board, International
- Lustgarten Innovation & Collaboration Award Committee, International
- Lustgarten-AACR Pancreatic Cancer Research Grant Scientific Review Committee, National
- Lustgarten-AACR Pancreatic Cancer Research Grant Scientific Review Committee, National
- Lustgarten-AACR Pancreatic Cancer Research Grant Scientific Review Committee, International
- Mark Foundation for Cancer Research Grant Scientific Review Committee, International
- Merck Groups Scientific Advisory Board, International
- NCI Esophagogastric Immunotherapy CPTM, National
- NIH/NCI U01 Consortium for Pancreatic Ductal Adenocarcinoma Translation Studies on the Tumor Microenvironment, National
- PanCAN Transnational Accelerator Award Scientific Review Committee (member), International
- Pancreatic Cancer Action Network (PanCAN), National
- Pancreatic Cancer Action Network Scientific and Medical Advisory Board, National
- Pancreatic Cancer Action Network Therapeutic Accelerator Award Grant Review Committee, National
- Penn GI Transformational Grant Review Committee, Local
- Penn Institute for RNA Innovation's Pilot Grant Scientific Review Committee, Local
- Robert L Fine Cancer Research Foundation, National
- The American Society for Clinical Investigation Membership., National
- Penn Gastrointestinal Cancer Program
Treatments and conditions
Research
Publications
Andrew H Ko, Alexander C Jordan, Evan Tooker, Simon F Lacey, Renee B Chang, Yan Li, Alan P Venook, Margaret Tempero, Lloyd Damon, Lawrence Fong, Mark H O'Hara, Bruce L Levine, J Joseph Melenhorst, Gabriela Plesa, Carl H June, Gregory L Beatty Dual Targeting of Mesothelin and CD19 with Chimeric Antigen Receptor-Modified T Cells in Patients with Metastatic Pancreatic Cancer , Molecular Therapy , 28(11): 2020,2367
Lee J.W., Stone M.L., Porrett P.M., Thomas S.K., Komar C.A., Li J.H., Delman D., Graham K., Gladney W.L., Hua X., Gao M., Liu D., Borad M.J., Ramanathan R.K., Carpenter E.L., Ji A., de Beer M.C., de Beer F.C., Webb N.R., and G.L. Beatty Hepatocytes direct the formation of a pro-metastatic niche in the liver , Nature, 567(7747): 2019,249-252
Xu, J., Sai, H., Li, Y., Jordan, A.C., McGettigan, S.E., Chen, J-H., Bedoya, F., Fraietta, J.A., Gladney, W.L., Melenhorst, J.J., and G.L. Beatty Peripheral blood T cell fitness is diminished in patients with pancreatic carcinoma but can be improved with homeostatic cytokines , Cell Mol Gastroenterol Hepatol, 8(4): 2019,656-658
Liu M, O'Connor RS, Trefely S, Graham K, Snyder NW, Beatty GL. Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47-mediated 'don't eat me signal' , Nat Immunol, 20(3): 2019,265-275
Beatty GL, O'Hara MH, Lacey SF, Torigian DA, Nazimuddin F, Chen F, Kulikovskaya IM, Soulen MC, McGarvey M, Nelson AM, Gladney WL, Levine BL, Melenhorst JJ, Plesa G, June CH. Activity of mesothelin-specific chimeric antigen receptor T cells against pancreatic carcinoma metastases in a phase 1 trial. , Gastroenterology, 155(1): 2018,29-32
Long KB, Gladney WL, Tooker GM, Graham K, Fraietta JA, Beatty GL. IFNγ and CCL2 Cooperate to Redirect Tumor-Infiltrating Monocytes to Degrade Fibrosis and Enhance Chemotherapy Efficacy in Pancreatic Carcinoma. , Cancer Discov, 6(4): 2016,400-413
Beatty GL, Gladney WL. Immune escape mechanisms as a guide for cancer immunotherapy , Clin Cancer Res, 21(4): 2015,687
Beatty GL, Winograd R, Evans RA, Long KB, Luque SL, Lee JW, Clendenin C, Gladney WL, Knoblock DM, Guirnalda PD, Vonderheide RH. Exclusion of T Cells From Pancreatic Carcinomas in Mice Is Regulated by Ly6C(low) F4/80(+) Extratumoral Macrophages. , Gastroenterology, 149(1): 2015,201-10
Beatty, GL., Torigian, DA., Chiorean EG, Saboury B, Brothers, A., Alavi A. Troxel, AB, Sun W, Teitelbaum UR, Vonderheide RH, PJ O'Dwyer A phase I study of an agonist CD40 monoclonal antibody (CP-870,893) in combination with gemcitabine in patients with advanced pancreatic ductal adenocarcinoma , Clin Cancer Res., 19(22): 2015,6286-95
Beatty GL, Chiorean EG, Fishman MP, Saboury B, Teitelbaum UR, Sun WJ, Huhn RD, Song WR, Li DG, Sharp LL, Torigian DA, O'Dwyer PJ, Vonderheide RH CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans. , Science, 331(6024): 2011,1612-1616