Giorgos C. Karakousis, MD
Endocrine and Oncologic Surgery
Headshot of Giorgos C. Karakousis, MD

Giorgos C. Karakousis, MD

Endocrine and Oncologic Surgery
Accepting new patients
Sees patients age 18 and up
Penn Endocrine and Oncologic Surgery Perelman 3rd Floor
Headshot of Giorgos C. Karakousis, MD
Penn Medicine Provider

About me

  • Chief, Division of Endocrine and Oncologic Surgery
  • The Emilie and Roland T. deHellenbranth Professor in Surgery II

My education and training

  • University of Pennsylvania School of MedicineMedical School
  • Yale University School of MedicineGraduate School
  • University of Pennsylvania Health SystemResidency
  • University of Pennsylvania Health SystemFellowship
  • Memorial Sloan-Kettering Cancer CenterFellowship
Watch video featuring Giorgos C. Karakousis, MD on YouTube

Spoken languages

English
English
Ελληνικά
Greek

Reviews

Average Rating

1005 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Anonymous
September 2026
He has a nice way of making a person feel comfortable.
Anonymous
September 2026
Took their time answering my questions. Did not feel rushed.
Anonymous
September 2026
Very nice and active of my biosy. Tell me how if going to be
Anonymous
August 2026
dr karakousis is an excellent doctor in every phase of care. my appointment today was scheduled for 2:45, but didn't get to see the doctor until 5;30

Insurance accepted

Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.

Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
Dr. Karakousis is a Penn Medicine physician.

Qualifications and experience

Treatments and conditions

Research

Publications

Simons RA, Vargas GM, Farooq MS, Miura JT, Karakousis GC. 2025 CPT Code Revisions Will Have a Significant Impact on the Classification of Retroperitoneal Sarcoma Resection , J Am Coll Surg, 242: 2026,1696-1698


Tsingas K, Thomas M, Reale M, Xiao M, Wickramasinghe J, Chen Y, Duong B, Lucas A, Thacker G, Li H, Mou H, Ramirez-Salazar E, Elbasir A, Villanueva J, Xu X, Flowers A, Karakousis GC, Miura JT, Mitchell TC, Amaravadi RK, Schuchter LM, Liu S, Long Q, Hoon DSB, Ramos RI, Catbagan JJ, Bustos MA, Gershenwald JE, Simon JM, Wargo JA, Davies MA, Lu Y, Mills GB, Cohen S, Lawless A, Sharova T, Frederick DT, Flaherty KT, Hacohen N, Boland GM, Auslander N, Herlyn M. Melanoma-patient-derived xenograft multi-omics resource melPDomiX maps gain- and loss-of-function alterations , Cell Rep, 45: 2026,117455


Farooq MS, Jona A, Vargas GM, Simons RA, Miura JT, Karakousis GC, Etherington MS. Patient selection, practice patterns, and perioperative outcomes for robotic splenectomy: a contemporary ACS-NSQIP analysis , Surg Endosc: 2026


Liu S, Rook AH, Huang AC, Maity A, Qin Z, Chen Y, Song D, Deng Y, Huang Z, Karakousis GC, Mitchell TC, Amaravadi RK, Schuchter LM, Binder ZA, O'Rourke DM, Herlyn M, Guo W, Xu X. Topical resiquimod elicits systemic protection and improves anti-PD1 therapy in melanoma via priming of CD8+ T cells , Cancer Immunol Res: 2026


Acker RC, Sharpe JE, Williams S, Landau SI, Rowe J, Fraker D, Karakousis GC, Wachtel H, Kelz RR. Comparing Resident Team Performance in Complex Surgical Oncology: A Single-Institution Cohort Study , Ann Surg Oncol: 2026


Acker RC, Sharpe J, Williams S, Landau S, Rowe J, Fraker D, Karakousis GC, Wachtel H, Kelz RR. ASO Visual Abstract: Comparing Resident Team Performance in Complex Surgical Oncology: A Single-Institution Cohort Study , Ann Surg Oncol: 2026


Karakousis G. Pre-operative Radiation for Resectable Retroperitoneal Sarcoma: Where are we With Risk-benefit Calculus? , Ann Surg: 2026


Wei S, Deng Y, Lee J, Lan H, Yang Z, Labrie M, Betts CB, Duan H, Tate B, Pucilowska J, Frederick D, Lawless AR, Sharova T, Yang Y, Hu W, Beasley GM, Schuchter LM, Wang X, Xu W, Yong G, Vandenberg MEG, Torigian DA, Sivagnanam S, Du K, Sugarman E, McGettigan S, Zheng C, Al-Rohil RN, Selim MA, Datto MB, López GY, Nair SK, Ashley DM, Xu X, Amaravadi RK, Karakousis GC, O'Rourke DM, Brem S, O'Malley BW, Demirkan G, Yu S, Lu Y, Camp T, Patterson JA, Wei Z, Corless C, Gabrilovich DI, Mou Y, Flaherty KT, Coussens LM, Boland G, Herlyn M, Mills G, Liu L, Zhang G. A longitudinal, multi-omic atlas reveals the emergence of a spatially organized immunosuppressive ecosystem in resistant melanoma , Cell Rep Med, 7: 2026,102716


Kapoor D, Shaikh U, Valdes-Morales K, Trifoi MD, Lin SK, Deitermann AM, Banala M, Zhang E, Easo N, Lubeck M, Haynes D, Lewis D, Nugent ST, Etzkorn JR, Jariwala NN, Zhang J, Walker JL, Higgins HW 2nd, Sobanko JF, Giordano CN, Daneshpajouhnejad P, Modi M, Lin IC, Chang B, Wink J, Karakousis G, Miura J, Miller CJ. Response to Xu et al., "Letter to Editor 'Mohs micrographic surgery reduces the risk of reconstruction with positive margins, repeat surgeries, and time to definitive reconstruction compared to conventional excision of hand and foot melanomas: A retrospective cohort study'" , J Am Acad Dermatol: 2026


Wang H, Liu S, Sinha P, Liu F, Zhang X, Guo Y, Goncalves B, Zheng Q, Mou H, Yang J, Huang L, Miao F, Zeng T, Karakousis G, Huang AC, Mitchell T, Amaravadi R, Schuchter L, Milone M, Guo W, June C, Herlyn M, Fan Y, Xu X. DR5 CAR-T cells target melanoma and suppress MDSCs with minimal toxicity , Mol Ther, 34: 2026,1465-1482