Frank S. Lee, MD, PhD
Pathology and Laboratory Medicine
Sees patients age 18 and up
Penn Pathology and Laboratory Medicine HUP
Headshot of Frank S. Lee, MD, PhD
Penn Medicine Provider

About me

  • Professor of Pathology and Laboratory Medicine

My clinical expertise is in medical (autopsy) pathology.

Education and training

  • Medical School: Harvard University
  • Residency: Mass General Brigham Healthcare Center - Chestnut Hill
  • Fellowship: Mass General Brigham Healthcare Center - Chestnut Hill

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
Dr. Lee is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Lee, F.S. Hypoxia Inducible Factor pathway proteins in high-altitude mammals , Trends Biochem. Sci., 49: 2024,79-92


Jorgensen, K.#, Song, D.#, Weinstein, J., Garcia, O.A., Pearson, L.N., Inclan, M., Rivera-Chira, M., Leon-Velarde, F., Kiyamu, M., Brutsaert, T.D., Bigham, A.W.*, and Lee, F.S.* High-Altitude Andean H194R HIF2A Allele is a Hypomorphic Allele. , Mol. Biol. Evol., 40: 2023,msad162


Song D., Peng K., Palmer B.E., & Lee F.S. The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HIF-α , EMBO J, 41: 2022,e112059


Song, D., Bigham, A.W., & Lee, F.S. High-altitude deer mouse Hypoxia inducible factor-2α shows defective interaction with CREB-binding protein. , J. Biol. Chem., 296: 2021,100461


Song, D., Navalsky, B.E., Guan, W., Ingersoll, C., Wang, T., Loro, E., Eeles, L., Matchett, K.B., Percy, M.J., Medina, R.J., Khurana, T.S., Bigham, A.W., Lappin, T.R., & Lee, F.S. Tibetan PHD2, an allele with loss of function properties , Proc. Natl. Acad. Sci. USA, 117: 2020,12230-12238


Bigham, A.W., & Lee, F.S. Human high-altitude adaptation: forward genetics meets the HIF pathway , Genes & Dev, 28(20): 2014,2189-2204


Song, D., Li, L.-S., Arsenault, P.R., Tan, Q., Bigham, A.W., Heaton-Johnson, K.J., Master, S.R., & Lee, F.S. Defective Tibetan PHD2 Binding to p23 Links High Altitude Adaption to Altered Oxygen Sensing , J. Biol. Chem., 289(21): 2014,14656–14665


Percy, M.J., Furlow, P.W., Lucas, G.W., Li, X., Lappin, T.R.J., McMullin, M.F., & Lee, F.S. A gain of function mutation in the HIF2A gene in familial erythrocytosis. , N Engl J Med , 358(2): 2008,162-168


Percy M.J., Zhao Q., Flores A., Harrison C., Lappin T.R., Maxwell P.H., McMullin M.F.*, & Lee F.S.* A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis. , Proc Natl Acad Sci U S A, 103(3): 2006,654-659


Yu, F., White, S.B., Zhao, Q., & Lee, F.S. HIF-1α Binding to VHL is Regulated by Stimulus-Sensitive Proline Hydroxylation , Proc. Natl. Acad. Sci. USA, 98(17): 2001,9630-9635


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