Frank S. Lee, MD, PhD
Pathology and Laboratory Medicine
Sees patients age 18 and up
Penn Pathology and Laboratory Medicine HUP
Penn Medicine Provider
About me
- Professor of Pathology and Laboratory Medicine
My clinical expertise is in medical (autopsy) pathology.
My education and training
- Medical School: Harvard University
- Residency: Mass General Brigham Healthcare Center - Chestnut Hill
- Fellowship: Mass General Brigham Healthcare Center - Chestnut Hill
Spoken languages
English
English
Insurance accepted
Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.
- Aetna Advantra Cares D-SNP
- Aetna Advantra Credit Value
- Aetna Advantra Eagle HMO
- Aetna Advantra Eagle POS
- Aetna Advantra Premier Plus PPO
- Aetna Advantra Value
- Aetna Advantra Value Plus
- Aetna APCN Plus (Multi-Tier)
- Aetna Better Health Kids (CHIP) - DH Only
- Aetna Flexible Five
- Aetna Freedom Core
- Aetna Gold
- Aetna HMO
- Aetna Philly Prime
- Aetna POS
- Aetna PPO APCN
- Aetna Premier
- Aetna Premier Plus
- Aetna Savings Plus
- Aetna Signature Administrators
- Aetna Student Health Plan PPO
- Aetna Upfront Advantage
- First Health HMO
- First Health POS
- First Health PPO
- Meritain - Aramark (Other)
- Meritain - Aramark (Pennsylvania Premier Medical Plan)
- Centivo EPO
- Cigna Healthcare EPO
- Cigna Healthcare HMO
- Cigna Healthcare POS
- Cigna Healthcare PPO
- Claim Watcher (Homestead/ INDECs) Open Access
- Clover Health Choice
- Clover Health Choice Value PPO
- Clover Health Classic HMO
- Clover Health Value
- Devoted Health Choice Giveback Pennsylvania (PPO)
- Devoted Health Choice Pennsylvania (PPO)
- Devoted Health Choice Plus Pennsylvania (PPO)
- Devoted Health Core Pennsylvania (HMO)
- Devoted Health Dual Plus Pennsylvania (HMO D-SNP)
- Devoted Health Giveback Pennsylvania (HMO)
Locations
Penn Medicine hospital privileges
- Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
- Pennsylvania Hospital: Has privileges to treat patients in the hospital.
- Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
Qualifications and experience
- Pathology - Anatomic Pathology, 1994
- American Association for the Advancement of Science, National
- American Federation for Aging Research National Scientific Advisory Council, National
- American Heart Association, National
- American Heart Association Peer Review Committee, National
- American Society for Biochemistry and Molecular Biology, National
- American Society of Hematology, National
- The Academy of Medical Sciences (U.K.), International
Treatments and conditions
Research
Publications
Lee, F.S. Hypoxia Inducible Factor pathway proteins in high-altitude mammals , Trends Biochem. Sci., 49: 2024,79-92
Jorgensen, K.#, Song, D.#, Weinstein, J., Garcia, O.A., Pearson, L.N., Inclan, M., Rivera-Chira, M., Leon-Velarde, F., Kiyamu, M., Brutsaert, T.D., Bigham, A.W.*, and Lee, F.S.* High-Altitude Andean H194R HIF2A Allele is a Hypomorphic Allele. , Mol. Biol. Evol., 40: 2023,msad162
Song D., Peng K., Palmer B.E., & Lee F.S. The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HIF-α , EMBO J, 41: 2022,e112059
Song, D., Bigham, A.W., & Lee, F.S. High-altitude deer mouse Hypoxia inducible factor-2α shows defective interaction with CREB-binding protein. , J. Biol. Chem., 296: 2021,100461
Song, D., Navalsky, B.E., Guan, W., Ingersoll, C., Wang, T., Loro, E., Eeles, L., Matchett, K.B., Percy, M.J., Medina, R.J., Khurana, T.S., Bigham, A.W., Lappin, T.R., & Lee, F.S. Tibetan PHD2, an allele with loss of function properties , Proc. Natl. Acad. Sci. USA, 117: 2020,12230-12238
Bigham, A.W., & Lee, F.S. Human high-altitude adaptation: forward genetics meets the HIF pathway , Genes & Dev, 28(20): 2014,2189-2204
Song, D., Li, L.-S., Arsenault, P.R., Tan, Q., Bigham, A.W., Heaton-Johnson, K.J., Master, S.R., & Lee, F.S. Defective Tibetan PHD2 Binding to p23 Links High Altitude Adaption to Altered Oxygen Sensing , J. Biol. Chem., 289(21): 2014,14656–14665
Percy, M.J., Furlow, P.W., Lucas, G.W., Li, X., Lappin, T.R.J., McMullin, M.F., & Lee, F.S. A gain of function mutation in the HIF2A gene in familial erythrocytosis. , N Engl J Med , 358(2): 2008,162-168
Percy M.J., Zhao Q., Flores A., Harrison C., Lappin T.R., Maxwell P.H., McMullin M.F.*, & Lee F.S.* A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis. , Proc Natl Acad Sci U S A, 103(3): 2006,654-659
Yu, F., White, S.B., Zhao, Q., & Lee, F.S. HIF-1α Binding to VHL is Regulated by Stimulus-Sensitive Proline Hydroxylation , Proc. Natl. Acad. Sci. USA, 98(17): 2001,9630-9635