Fiona Simpkins, MD
Gynecologic Oncology
Accepting new patients
Sees patients age 18 and up
Jordan Center for Gynecologic Cancers
Penn Medicine Provider

About me

  • Hilarie L. and Mitchell L. Morgan President's Distinguished Professor in Women's Health

Education and training

  • Medical School: Temple University School of Medicine
  • Residency: Johns Hopkins Hospital
  • Fellowship: National Institutes of Health
  • Fellowship: Cleveland Clinic Foundation

What my patients think about me

Average Rating

115 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

October 2025
dr simpkins came highly recommended by a family member
October 2025
instills confidence, experienced, patient, positive
October 2025
she was able to explain some research on my situation.
September 2025
she is very thorough, explains everything so i understand it, and has the best bedside manner.

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Chester County Hospital: Has privileges to treat patients in the hospital.
Dr. Simpkins is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Onecha VV, Suarez-García D, Bosque JJ, Lee H, Simpkins F, Gitto SB, Pryma DA, Bertolet A. Space- and Time-Defined Monte Carlo Dosimetry Explains Ovarian Cancer Cell Viability in Targeted α-Particle Therapy With Astatine 211-ParaThanatrace , Int J Radiat Oncol Biol Phys. (IF = 6.5): 2025


Smith AJB, Spataro S, Heintz J, Simpkins F, Ko EM Disparities in clinical drug trial participation in endometrial cancer: a real-world analysis. , Am J Obstet Gynecol. (Impact factor 8): 2025


Xu H, George E, Gallo D, Medvedev S, Wang X, Kryczka R, Hyer ML, Fourtounis J, Stocco R, Aguado-Fraile E, Petrone A, Yin SY, Shiwram A, Anderson M, Kim H, Liu F, Marshall CG, Simpkins F Targeting CCNE1 amplified ovarian and endometrial cancers by combined inhibition of PKMYT1 and ATR. , Nature Communications (Impact factor 17): 2025


Fiona Simpkins, Alexandra Leary, Lyndsay Willmott, Bradley J. Monk, , Jean-Sébastien Frenel, David C. Starks, Meena Okera, Angeles Alvarez Secord, David M. O’Malley, Lainie Martin, Kaissa Ouali, Martin K. Oehler, Jeffrey C. Goh, Brian M. Slomovitz, Peter C. Lim, Catherine M. Shannon, Robert Neff, Doris Kim, Hailun Li, Danielle Jandial, Floor J. Backes Cyclin E1 is a Predictive Biomarker of Azenosertib Benefit in Platinum-Resistant Ovarian Cancer (PROC): Outcomes From Part 1b of the DENALI Study (GOG-3066) , Gynecology Oncology; plenary, SGO Annual Meeting, March 2025: 2025


Erin George, Lakeisha Mulugeta-Gordon, Emily M Ko, Sharon Wu, Joanne Xiu, Nathaniel Jones, Premal H Thaker, Thomas J Herzog, Eric J Brown, Dineo Khabele, Fiona Simpkins Impact of CCNE1 Amplification on Molecular Signatures and Patient Outcomes in High Grade Serous Ovarian and Endometrial Cancer , Gynecology Oncology; plenary, SGO Annual Meeting, March 2025: 2025


Smith AJ, Pancoe S, Lynch MP, Wachlin M, Powell K, Hinkle SN, Koelper NC, Doherty M, Bekelman JE, Simpkins F, Ko EM Rideshare services for transportation assistance in gynecologic oncology: a quality improvement study , BMC Health Serv Res: 2025


Kim D, Chung H, Liu W, Jeong K, Ozmen TY, Ozmen F, Rames MJ, Kim S, Guo X, Jameson N, de Jong PR, Yea S, Harford L, Li J, Mathews CA, Doroshow DB, Charles VJ, Kim D, Fischer K, Samatar AA, Jubb A, Bunker KD, Blackwell K, Simpkins F, Meric-Bernstam F, Mills GB, Harismendy O, Ma J, Lackner MR Cyclin E1/CDK2 activation defines a key vulnerability to WEE1 kinase inhibition in gynecological cancers , NPJ Precis Oncol (Impact Factor 8): 2025


Liu YL, Mathews CA, Simpkins F, Cadoo KA, Provencher D, McCormick CC, ElNaggar AC, Altman AD, Gilbert L, Black D, Kabil N, Taylor RN, Barnicle A, Munley JY, Aghajanian C Olaparib as treatment for platinum-sensitive relapsed ovarian cancer by BRCA mutation and homologous recombination deficiency: Phase 2 LIGHT study final overall survival analysis , Cancer (IF = 5): 2025


Weeks JK, Pantel AR, Gitto SB, Liu F, Schubert EK, Pryma DA, Farwell MD, Mankoff DA, Mach RH, Simpkins F, Lin LL [18F]Fluorthanatrace PET in Ovarian Cancer: Comparison with [18F]FDG PET, Lesion Location, Tumor Grade, and Breast Cancer Gene Mutation Status. , J Nucl Med (IF= 9): 2025


Barnicle A, Ray-Coquard I, Rouleau E, Cadoo K, Simpkins F, Aghajanian C, Leary A, Poveda A, Lheureux S, Pujade-Lauraine E, You B, Ledermann J, Matulonis U, Gourley C, Timms KM, Lai Z, Hodgson DR, Elks CE, Dearden S, Egile C, Lao-Sirieix P, Harrington EA, Brown JS Patterns of genomic instability in > 2000 patients with ovarian cancer across six clinical trials evaluating olaparib , Genome Medicine (Impact Factor 12): 2024