Ernestina Schipani, MD, PhD
Penn Medicine Provider

About me

  • William Wikoff Smith Professor of Orthopaedic Surgery

Insurance accepted

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Qualifications and experience

Treatments and Conditions

My research

Höppner J, Firat D, Parvez-Khan M, Reyes M, Hanna P, Yadav PS, Dean T, Ramos-Torres KM, Brugarolas P, Collins MT, Wein MN, Liu S, Gellman SH, Schipani E, Kronenberg HM, Gardella TJ, Jüppner H. A mouse model of Jansen's metaphyseal chondrodysplasia for investigating disease mechanisms and candidate therapeutics , Proc Natl Acad Sci U S A, 122: 2025,e2500176122


Lanzolla G, Sabini E, Beigel K, Khan MP, Sherry Liu X, Wang D, Laslow B, Taylor D, Bellido T, Giaccia A, Schipani E. Pharmacological inhibition of HIF2 protects against bone loss in an experimental model of estrogen deficiency , Proc Natl Acad Sci U S A, 121: 2024,e2416004121


Khan MP, Sabini E, Beigel K, Lanzolla G, Laslow B, Wang D, Merceron C, Giaccia A, Long F, Taylor D, Schipani E. HIF1 activation safeguards cortical bone formation against impaired oxidative phosphorylation , JCI Insight, 9: 2024,e182330


Sabini E, Schipani E. The hypoxia signature across skeletal progenitor cells , J Bone Miner Res, 39: 2024,373-374


Lanzolla G, Merceron C, Khan MP, Sabini E, Giaccia A, Schipani E. Osteoblastic erythropoietin is not required for bone mass accrual , JBMR Plus, 8: 2024,ziae052


Schipani E, Carmeliet G. Cell metabolism and bone cells , Bone Rep, 19: 2023,101719


Reyes M, Firat D, Hanna P, Khan M, Bruce M, Shvedova M, Kobayashi T, Schipani E, Gardella TJ, Jüppner H. Substantially Delayed Maturation of Growth Plate Chondrocytes in "Humanized" PTH1R Mice with the H223R Mutation of Jansen's Disease , JBMR Plus, 7: 2023,e10802


Warren A, Porter RM, Reyes-Castro O, Ali MM, Marques-Carvalho A, Kim HN, Gatrell LB, Schipani E, Nookaew I, O'Brien CA, Morello R, Almeida M. The NAD salvage pathway in mesenchymal cells is indispensable for skeletal development in mice , Nat Commun, 14: 2023,3616


Sabini E, Arboit L, Khan MP, Lanzolla G, Schipani E. Oxidative phosphorylation in bone cells , Bone Rep, 18: 2023,101688


Oranger A, Zerlotin R, Buccoliero C, Sanesi L, Storlino G, Schipani E, Kozloff KM, Mori G, Colaianni G, Colucci S, Grano M. Irisin Modulates Inflammatory, Angiogenic, and Osteogenic Factors during Fracture Healing , Int J Mol Sci, 24: 2023,1809


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