Eline T. Luning Prak, MD, PhD
Pathology and Laboratory Medicine
Sees patients age 18 and up
Penn Pathology and Laboratory Medicine HUP
Penn Medicine Provider
About me
- Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Molecular Immunology- I have expertise in next-generation sequencing-based assays of immune repertoires and computational analysis of the immune repertoire. I direct a research lab that performs immune repertoire profiling of antibody gene rearrangements in B cells and T cell receptor gene rearrangements in T cells. Immune repertoire profiling can be used clinically for the evaluation of malignant and non-malignant clonal expansions, clone tracking, minimal residual disease assessment, evaluation of immune responses and immunologic disorders ranging from immunodeficiency to autoimmunity. I am the past-president of the Adaptive Immune Receptor Repertoire (AIRR) Community, an international group of investigators who study immune repertoires and share data.
Flow Cytometry- I have expertise in clinical and translational immunophenotyping experiments. I direct the Human Immunology Core which develops and performs multicolor immunophenotyping panels and other translational immunology assays for early-phase clinical trials. I am familiar with human B cell lymphocyte maturation, but also provide input into the design of immunophenotyping panels for malignant B and T cell disorders. I also serve as a consultant to HUP allergy immunology physicians who use clinical flow cytometry data as part of an immunodeficiency evaluation.
Autoimmune and infectious disease serology- I have expertise in autoimmune serology, autoantibody profiling and serologic assays for infectious diseases including SARS-CoV-2 and lyme disease. I am the Associate Director of the Clinical Immunology laboratory at the Hospital of the University of Pennsylvania, which performs a wide range of clinical assays.
HLA typing and allosensitization evaluations- I have expertise in HLA and anti-HLA immune responses, and provide input into clinical test design, evaluation and test reporting for the HLA lab at the Hospital of the University of Pennsylvania.
My education and training
- Medical School: University of Pennsylvania School of Medicine
- Residency: University of Pennsylvania Health System
- Fellowship: University of Pennsylvania Health System
Spoken languages
English
English
Dutch
Dutch
Insurance accepted
Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.
- Aetna Advantra Cares D-SNP
- Aetna Advantra Credit Value
- Aetna Advantra Eagle HMO
- Aetna Advantra Eagle POS
- Aetna Advantra Premier Plus PPO
- Aetna Advantra Value
- Aetna Advantra Value Plus
- Aetna APCN Plus (Multi-Tier)
- Aetna Better Health Kids (CHIP) - DH Only
- Aetna Flexible Five
- Aetna Freedom Core
- Aetna Gold
- Aetna HMO
- Aetna Philly Prime
- Aetna POS
- Aetna PPO APCN
- Aetna Premier
- Aetna Premier Plus
- Aetna Savings Plus
- Aetna Signature Administrators
- Aetna Student Health Plan PPO
- Aetna Upfront Advantage
- First Health HMO
- First Health POS
- First Health PPO
- Meritain - Aramark (Other)
- Meritain - Aramark (Pennsylvania Premier Medical Plan)
- Centivo EPO
- Cigna Healthcare EPO
- Cigna Healthcare HMO
- Cigna Healthcare POS
- Cigna Healthcare PPO
- Claim Watcher (Homestead/ INDECs) Open Access
- Clover Health Choice
- Clover Health Choice Value PPO
- Clover Health Classic HMO
- Clover Health Value
- Devoted Health Choice Giveback Pennsylvania (PPO)
- Devoted Health Choice Pennsylvania (PPO)
- Devoted Health Choice Plus Pennsylvania (PPO)
- Devoted Health Core Pennsylvania (HMO)
- Devoted Health Dual Plus Pennsylvania (HMO D-SNP)
- Devoted Health Giveback Pennsylvania (HMO)
Locations
Penn Medicine hospital privileges
- Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
- Pennsylvania Hospital: Has privileges to treat patients in the hospital.
- Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
Qualifications and experience
- Pathology - Clinical
- Academy of Clinical Laboratory Scientists and Physicians, National
- Adaptive Immune Receptor Repertoire Community (AIRR-C), International
- American Association for Investigative Pathology (ASIP), National
- American Association of Immunologists, National
- American Society of Clinical Pathology, National
- Autoimmunity Association, International
- Chan Zuckerberg Institute, National
- College of American Pathologists, National
- Colton Consortium: Penn Colton Center for Autoimmunity, International
- Immune Epitope Database (IEDB), National
- Institute for Diabetes, Obesity and Metabolism, Local
- Institute for Translational Medicine and Therapeutics, Local
- Israeli Ministry for Innovation, Science and Technology, International
- Juvenile Diabetes Research Foundation, National
- Lupus Research Institute, National
- National Science Foundation, National
- NIH Epitope Working Group-panel of reviewers that periodically reviews the NIH Epitope Discovery Program, National
- Penn Institute for Immunology, Local
- Swiss National Science Foundation, International
- The Antibody Society, International
- The Dunhill Medical Trust, International
- UKRI Medical Research Council, International
Treatments and conditions
Research
Publications
Medina-Serpas, M., Brusko, M., Golden, G.J., Campbell-Thompson, M., Rogers, T.J., Reardon, S., Posgai, A.L., Bacher, R., Luning Prak, E.T., Liu, C., Kaestner, K.H., Naji, A., Betts, M.R., McIntyre, L.M., Atkinson, M.A. and T. M. Brusko Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-b signature in type 1 diabetes , Cell Reports, 45(4): 2026,117144
Mao, X., Konigsberg, J., Noorchashm, N., Meng, W., Knox, J.J., Golden, G.J., Hamilton, J.T., Maxwell, T.K., Liu, C., Betts, M.R., Willi, S.M., Naji, A., Hanley, P. and E.T. Luning Prak Differential Contributions of IgM and IgG Autoantibodies to Serologic IA2 Reactivity in Type 1 Diabetes , Biomolecules, 16(4): 2026,500
Knox, J.J., Lee, I., Rosenfeld, A.M., Meng, W., Liu, F., Kearns, C., O'Doherty, U., Shaked, A., Olthoff, K.M. and E.T. Luning Prak B cell subset representation predicts COVID-19 vaccine response in solid organ transplant recipients , The Journal of Infectious Diseases, 232(3): 2025,e466-e475
Bukhari, A.M., Meng, W., Rosenfeld, A.M., Luning Prak, E.T.^ and K.L. Knight^ (^co-senior and co-corresponding authors) IgM+IgD- B cells in human gut-associated lymphoid tissue have memory features and give rise to IgM+ and IgA+ antibody-secreting cells , Scientific Reports: 2025
Conter, L., Smita, S., Callahan, D., Wu, S., Brown, A., Nickerson, K.M., Elsner, R.A., Meng, W., Peres, A., Yaari, G., Kleinstein, S.H., Luning Prak, E.T., Luo, W. and M.J. Shlomchik BLIMP1 controls GC B cell expansion and exit through regulating cell cycle progression and key transcription factors BCL6 and IRF4 , Cell Reports, 44(7): 2025
Golden, G. J., Wu, V.H., Hamilton, J.T., Amses, K., Japp, A.S., Liu, C., Pampena, M.B., Kuri-Cervantes, L., Knox, J.J., Gardner, J.S., HPAP Consortium, Atkinson, M.A., Brusko, T.M., Luning Prak, E.T., Kaserner, K.H., Naji, A., and M.R. Betts Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset , Nature Communications, 16(1): 2025,4621
S. J. Hanna, R. H. Bonami, B. Corrie, M. Westley, A. L. Postal, E.T. Luning Prak, F. Breden, A.W. Michels, T.M. Brusko, and on behalf of the Type 1 Diabetes AIRR Consortium The Type 1 Diabetes T cell Receptor and B cell Receptor Repository in the AIRR Data Commons: A Practical Guide for Access, Use, and Contributions Through the Type 1 Diabetes AIRR Consortium , Diabetologia, 68(1): 2024,186-202
Fu, J., Hsiao, T., Waffarn, E., Meng, W., Long, K.D., Frangaj, K., Jones, R., Gorur, A., Shtewe, A., Li, M., Muntnich, C.B., Rogers, K., Jiao, W., Velasco, M., Matusmoto, R., Kubota, M., Wells, S., Danzl, N., Ravelo, S., Luga, A., Vasilescu, E.R., Griesemer, A., Weiner, J., Farber, D.L., Luning Prak, E.T., Martinez, M., Kato, T., Hershberg, U. and M. Sykes Dynamic establishment and maintenance of the human intestinal B cell population and repertoire following transplantation in a pediatric-dominated cohort , Frontiers in Immunology, 15: 2024
Anderson, E., Powell, M., Yang, E., Kar, A., Leung, T., Sison, C., Steinberg, R., Mims, R., Choudhury, A., Espinosa, C., Okoye, N.C., Choi, E.J., Marder, G., Narain, S., Gregersen, P.K., Mackay, M., Diamond, B., Levy, T., Zanos, T.P., Khosroshanhi, A., Sanz, I., Luning Prak, E.T., Bar-Or, A., Merrill, J., Arriens, C., Pardo, G., Guthridge, J., James, J., Payne, A., Utz, P.J., Boss, J.M., Aranow, C. and A. Davidson Factors associated with immune responses to SARS-CoV-2 vaccination in individuals with autoimmune diseases , JCI Insight, 9(13): 2024
Chong, E.A., Kumashie, K.G., Chong, E.R., Fabrizio, J., Gupta, A., Svoboda, J., Barta, S.K., Walsh, K.M., Napier, E.B., Lundberg, R.K., Nasta, S.D., Gerson, J.N., Landsburg, D.J., Gonzalez, J., Gaano, A., Weirock, M.E., McAllister, C.M., Awofalaju, M., John, G.N., Kammerman, S.C., Novaceck, J., Pajarillo, R., Lundgreen, K.A., Tanenbaum, N., Douma, S., Drapeau, E.M., Adamski, S., D'Andrea, K., Pattekar, A., Hicks, A., Korte, S., Sharma, H., Herring, S., Williams, J.C., Hamilton, J.T., Bates, P., Hensley, S.E., Luning Prak, E.T., Greenplate, A.R., Wherry, E.J., Schuster, S.J., Ruella, M. and L.A. Vella Immunologic predictors of vaccine responsiveness in patients with lymphoma and CLL , Journal of Infectious Diseases: 2024