Penn Medicine Provider
Doris Adelheid Stoffers, MD

About me

  • Sylvan H. Eisman Professor of Medicine

Education and training

  • Medical School: Johns Hopkins University School of Medicine
  • Residency: Massachusetts General Hospital/Brigham and Women’s Hospital
  • Fellowship: Massachusetts General Hospital

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: On the medical staff, but does not have privileges to treat patients in the hospital.
Dr. Stoffers is a Penn Medicine physician.

Qualifications and experience

My research

Haemmerle MW, Batmanov K, Good AL, Scota A, Tersey S, Liebhaber S, Philpott C, Ghanem L and Stoffers DA RNA binding proteins PCBP1 and PCBP2 program pancreatic β cell translation , Molecular Metabolism, 98: 2025,102175


Yang X, Zanfardino A, Schiaffini R, Ishibashi J, Daniel B, Haemmerle MW, Rapini N, Piscopo A, Miraglia del Giudice E, Digilio MC, Iorio R, Mucciolo M, Cianfarani S, Iafusco D, Barbetti F, Stoffers DA Neonatal diabetes associated missense PDX1 variant disrupts chromatin association and protein-protein interaction , JCI Insight, 10(11): 2025,e189343


Oguh AU, Haemmerle MW, Sen S, Rozo AV, Shrestha S, Cartailler JP, Fazelinia H, Ding H, Preza S, Yang J, Yang X*, Sussel L, Alvarez-Dominguez JR, Doliba N, Spruce LA, Arrojo e Drigo R, and Stoffers DA. E3 ligase substrate adaptor SPOP fine tunes the UPR of pancreatic beta cells. , Genes and Development, 39(3-4): 2025,261-279


Haemmerle MW, Scota AV, Khosravifar M, Varney MJ, Sen S, Good AL, Yang X, Wells KL, Sussel L, Rozo AV, Doliba NM, Ghanem LR, Stoffers DA RNA-binding protein PCBP2 regulates pancreatic β cell function and adaptation to glucose , Journal of Clinical Investigation, 134(12): 2024,e172436


Drawshy Z, Neiman D, Fridlich O, Peretz A, Magenheim J, Rozo AV, Doliba NM, Stoffers DA, Kaestner KH, Schatz DA, Wasserfall C, Campbell-Thompson M, Shapiro J, Kaplan T, Shemer R, Glaser B, Klochendler A, Dor Y DNA Methylation-Based Assessment of Cell Composition in Human Pancreas and Islets , Diabetes, 73(4): 2024,554-564


Yang X, Raum JC, Kim J, Yu R, Yang J, Rice G, Li C, Won KJ, Stanescu DE, Stoffers DA A PDX1 cistrome and single-cell transcriptome resource of the developing pancreas. , Development, 1: 2022,149


Doliba NM, Rozo AV, Roman J, Qin W, Traum D, Gao L, Liu J, Manduchi E, Liu C, Golson ML, Vahedi G, Naji A, Matschinsky FM, Atkinson MA, Powers AC, Brissova M, Kaestner KH, Stoffers DA, HPAP Consortium α Cell dysfunction in islets from nondiabetic, glutamic acid decarboxylase autoantibody-positive individuals , J Clin Invest, 132(11): 2022,e156243


Zhu X, Gingrich MA, Soleimanpour SA, Stoffers DA, Gannon M Cell cycle regulation of the Pdx1 transcription factor in developing pancreas and insulin-producing β cells , Diabetes: 2020 ,under revision


Mosleh E, Ou K, Haemmerle MW, Tembo T, Yuhas A, Carboneau BA, Townsend SE, Bosma KJ, Gannon M, O'Brien RM, Stoffers DA, Golson ML Ins1-Cre and Ins1-CreER Gene Replacement Alleles Are Susceptible To Silencing By DNA Hypermethylation , Endocrinology, 1: 2020,161


Good AL, Haemmerle MW, Oguh A, Doliba NM and Stoffers DA. Metabolic stress activates an ERK/hnRNPK/DDX3X pathway in pancreatic β cells , Molecular Metabolism, 26: 2019,45-56


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