- Amyotrophic lateral sclerosis (ALS)
- Diabetic neuropathy
- Gait abnormality
- Guillain-Barre syndrome
- Multifocal motor neuropathy
- Myasthenia gravis
- Peripheral neuropathy
- Small fiber neuropathy
Defne Audrey Amado, MD, PHD
Neurology
Accepting new patients
Sees patients age 18 and up
Penn Neuroscience Center - Neurology
Penn Medicine Provider
About me
- Assistant Professor of Neurology at the Hospital of the University of Pennsylvania
My education and training
- University of Pennsylvania School of MedicineMedical School
- University of Pennsylvania Health SystemResidency
Spoken languages
English
English
Reviews
Insurance accepted
Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.
- Aetna Advantra Cares D-SNP
- Aetna Advantra Credit Value
- Aetna Advantra Eagle HMO
- Aetna Advantra Eagle POS
- Aetna Advantra Premier Plus PPO
- Aetna Advantra Value
- Aetna Advantra Value Plus
- Aetna APCN Plus (Multi-Tier)
- Aetna Better Health Kids (CHIP) - DH Only
- Aetna Flexible Five
- Aetna Freedom Core
- Aetna Gold
- Aetna HMO
- Aetna Philly Prime
- Aetna POS
- Aetna PPO APCN
- Aetna Premier
- Aetna Premier Plus
- Aetna Savings Plus
- Aetna Signature Administrators
- Aetna Student Health Plan PPO
- Aetna Upfront Advantage
- First Health HMO
- First Health POS
- First Health PPO
- Meritain - Aramark (Other)
- Meritain - Aramark (Pennsylvania Premier Medical Plan)
- Centivo EPO
- Cigna Healthcare EPO
- Cigna Healthcare HMO
- Cigna Healthcare POS
- Cigna Healthcare PPO
- Claim Watcher (Homestead/ INDECs) Open Access
- Clover Health Choice
- Clover Health Choice Value PPO
- Clover Health Classic HMO
- Clover Health Value
- Devoted Health Choice Giveback Pennsylvania (PPO)
- Devoted Health Choice Pennsylvania (PPO)
- Devoted Health Choice Plus Pennsylvania (PPO)
- Devoted Health Core Pennsylvania (HMO)
- Devoted Health Dual Plus Pennsylvania (HMO D-SNP)
- Devoted Health Giveback Pennsylvania (HMO)
Locations
Penn Medicine hospital privileges
- Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
- Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
- Pennsylvania Hospital: Has privileges to treat patients in the hospital.
Dr. Amado is a Penn Medicine physician.
Qualifications and experience
- Neurology, 2015
- American Academy of Neurology, National
- American Neurological Association, National
- American Society of Gene and Cell Therapy, National
- Scientific Advisory Board member, NabGen Inc., National
- Comprehensive ALS Center
- Neurocritical care
- Neuromuscular disorders care
- Peripheral nerve care
Treatments and conditions
Research
Publications
Amado DA, Robbins AB, Whiteman KR, Smith AR, Chillon G, Chen Y, Fuller JA, Patty NA, Izda A, Cheng C, Nelson S, Dichter AI, Mazzoni EO, Monteys AM, Davidson BL. AAV-based delivery of RNAi targeting ataxin-2 improves survival and pathology in TDP-43 mice. , Nature Communications, 16(1): 2025,5334
Amado DA, Davidson BL Gene Therapy for ALS: A Review , Molecular Therapy, 29(12): 2021,3345-3358
Amado DA, Rieders JM, Diatta F, Hernandez-Con P, Singer A, Mak JT, Zhang J, Lancaster E, Davidson BL, Chen-Plotkin AS. AAV-mediated progranulin delivery to a mouse model of progranulin deficiency causes T cell-mediated toxicity. , Molecular Therapy, 27(2): 2019,465-478
Masrori P, Amado DA. RAN translation as a dominant pathogenic axis in C9ORF72-associated ALS and FTD models. , Molecular Neurodegeneration, 21(1): 2026,46
Amado DA, Robbins A. The Emerging Landscape of Targeted Therapeutics for Genetic Neuromuscular Disorders. , Practical Neurology: 2023
Dawicki-McKenna J, Felix A, Waxman E, Cheng C, Amado DA, Ranum PT, Bogush A, Dungan LV, Maguire JA, Gagne AL, Heller EA, French DL, Davidson BL, Prosser B. Mapping PTBP2 binding in human brain identifies SYNGAP1 as a target for therapeutic splice switching. , Nature Communications, 14(1): 2023,2628
Mao F, Robinson J, Unger T, Amado DA, Elman L, Grossman M, Weintraub D, Wolk D, Lee E, Van Deerlin V, Porta SSs, Lee V, Trojanowski JQ, Chen-Plotkin AS. TMEM106B modifies TDP-43 pathology in human ALS brain and cell-based models of TDP-43 proteinopathy. , Acta Neuropathologica, 142(4): 2021,629-642
Amado D, Mingozzi F, Hui D, Bennicelli JL, Wei Z, Chen Y, Bote E, Grant RL, Golden JA, Narfstrom K, Syed NA, Orlin SE, High KA, Maguire AM, Bennett J. Safety and efficacy of subretinal readministration of a viral vector in large animals to treat congenital blindness. , Science Translational Medicine, 2(21): 2010,21ra16
Dratch L, Bardakjian TM, Johnson K, Babaian N, Gonzalez-Alegre P, Elman L, Quinn C, Guo MH, Scherer SS, Amado DA. The Importance of Offering Exome or Genome Sequencing in Adult Neuromuscular Clinics. , Biology, 13(2): 2024,93
Posavi M, Diaz-Ortiz M, Liu B, Swanson CR, Skrinak RT, Hernandez-Con P, Amado DA, Fullard M, Rick J, Siderowf A, Weintraub D, McCluskey L, Trojanowski JQ, Dewey RB Jr, Huang X, Chen-Plotkin AS. Characterization of Parkinson's disease using blood-based biomarkers: A multicohort proteomic analysis. , PLoS Medicine, 16(10): 2019,e1002931