Daniel P. Kelly, MD

Sees patients age 18 and up
Penn Medicine Provider

About me

  • Director, Cardiovascular Institute
  • Willard and Rhoda Ware Professor of Diabetes and Metabolic Diseases
  • Professor of Medicine in Pediatrics

Insurance accepted

Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.

Locations

Qualifications and experience

Treatments and Conditions

Research

Publications

Uchida K, Scarborough EA, Pruzinsky E, Stone KR, Hartman H, Kelly DP, Edwards JJ, Kehat I, Prosser BL mTORC1 and nucler ERK spatially control translation in cardiomyocytes through 4EBP1 phosphorylation , Science Signaling, 19(934): 2026


Gorgodze N, Matsuura TR, Nisini N, Berretta R, Recchia A, Werlen A, Wang T, Houser S, Kelly DP, Recchia FA The Medium Chain Fatty Acid Octanoate is a Beneficial Fuel for the Failing Heart , Am J Phsiol Heart Circ Physiol, 330(6): 2026,H1785-1790


Pruzinsky E, Batmanov K, Medeiros DM, Sulon SM, Sakamoto T, Leone TC, Khurana T, Kelly DP A Role for the Transcriptional Coregulator RIP140 in the Control of Muscle Endurance Fitness , JCI Insight: 2025


Berger JH, Shi Y, Matsuura TR, Batmanov K, Chen X, Tam K, Marshall M, Kue R, Patel J, Taing R, Callaway R, Griffin J, Kovacs A, Shanthappa DH, Miller R, Zhang BB, Roth Flach RJ, Kelly DP Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension , Scientific Reports, 15(1): 2025


Berger J, Matsuura TR, Bowman CE, Taing R, Patel J, Lai L, Leone TC, Reagan JD, Haldar SM, Arany Z, Kelly DP Sodium-glucose co-transporter 2 Inhibitors Act Independently of SGLT2 to Confer Benefit for Heart Failure with Reduced Ejection Fraction in Mice , CircRes: 2024


Yamamoto T, Maurya SK, Pruzinsky E, Batmanov K, Xiao Y, Sulon SM, Sakamoto T, Wang Y, Lai L, McDaid KS, Shewale SV, Leone TC, Koves TR, Muoi DM, Dierickx P, Lazar MA, Lewandowski ED, Kelly DP RIP140 deficiency enhances cardiac fuel metabolism and protects mice from heart failure , J Clin Invest, 133(9): 2023,e162309


Sakamoto T, Batmanov K, Wan S, Guo Y, Lai L, Vega RB, Kelly DP The nuclear receptor ERRgamma cooperates with the cardiogenic factor GATA4 to orchestrate cardiomyocyte differentiation , Nat Commun, 13(1): 2022,1991


Tomoya Sakamoto, Timothy R Matsuura, Shibiao Wan, David M Ryba, Junil Kim, Kyoung-Jae Won, Ling Lai, Christopher Petucci, Nataliya Petrenko, Kiran Musunuru, Rick B Vega, and Daniel P Kelly A Critical Role for Estrogen-related Receptor Signaling in Cardiac Maturation , Circulation Research: 2020


Gan Zhenji, Rumsey John, Hazen Bethany C, Lai Ling, Leone Teresa C, Vega Rick B, Xie Hui, Conley Kevin E, Auwerx Johan, Smith Steven R, Olson Eric N, Kralli Anastasia, Kelly Daniel P Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism. , The Journal of clinical investigation, 123(6): 2013,2564-75


Aubert Gregory, Martin Ola J, Horton Julie L, Lai Ling, Vega Rick B, Leone Teresa C, Koves Timothy, Gardell Stephen J, Krüger Marcus, Hoppel Charles L, Lewandowski E Douglas, Crawford Peter A, Muoio Deborah M, Kelly Daniel P The Failing Heart Relies on Ketone Bodies as a Fuel. , Circulation, 133(8): 2016,698-705