About me
- Director, Cardiovascular Institute
- Willard and Rhoda Ware Professor of Diabetes and Metabolic Diseases
- Professor of Medicine in Pediatrics
Locations
Qualifications and experience
- American Diabetes Association, National
- American Heart Association (AHA), National
- American Society for Clinical Investigation, National
- Amgen, National
- Association of American Physicians (AAP), National
- Center for Mitochondrial and Epigenomic Medicine (CMEM), Children’s Hospital of Philadelphia, Local
- Cytokinetics, National
- International Society of Heart Research, International
- NIDDK, National
- NIH, National
- Pfizer Cardiovascular, Metabolic, and Endocrine Diseases Therapeutic Area (CVMET) Scientific Advisory Panel (TASAP), National
- Pfizer Internal Medicine Research Unit (IMRU), National
- University of Utah, National
Treatments and Conditions
Research
Publications
Uchida K, Scarborough EA, Pruzinsky E, Stone KR, Hartman H, Kelly DP, Edwards JJ, Kehat I, Prosser BL mTORC1 and nucler ERK spatially control translation in cardiomyocytes through 4EBP1 phosphorylation , Science Signaling, 19(934): 2026
Gorgodze N, Matsuura TR, Nisini N, Berretta R, Recchia A, Werlen A, Wang T, Houser S, Kelly DP, Recchia FA The Medium Chain Fatty Acid Octanoate is a Beneficial Fuel for the Failing Heart , Am J Phsiol Heart Circ Physiol, 330(6): 2026,H1785-1790
Pruzinsky E, Batmanov K, Medeiros DM, Sulon SM, Sakamoto T, Leone TC, Khurana T, Kelly DP A Role for the Transcriptional Coregulator RIP140 in the Control of Muscle Endurance Fitness , JCI Insight: 2025
Berger JH, Shi Y, Matsuura TR, Batmanov K, Chen X, Tam K, Marshall M, Kue R, Patel J, Taing R, Callaway R, Griffin J, Kovacs A, Shanthappa DH, Miller R, Zhang BB, Roth Flach RJ, Kelly DP Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension , Scientific Reports, 15(1): 2025
Berger J, Matsuura TR, Bowman CE, Taing R, Patel J, Lai L, Leone TC, Reagan JD, Haldar SM, Arany Z, Kelly DP Sodium-glucose co-transporter 2 Inhibitors Act Independently of SGLT2 to Confer Benefit for Heart Failure with Reduced Ejection Fraction in Mice , CircRes: 2024
Yamamoto T, Maurya SK, Pruzinsky E, Batmanov K, Xiao Y, Sulon SM, Sakamoto T, Wang Y, Lai L, McDaid KS, Shewale SV, Leone TC, Koves TR, Muoi DM, Dierickx P, Lazar MA, Lewandowski ED, Kelly DP RIP140 deficiency enhances cardiac fuel metabolism and protects mice from heart failure , J Clin Invest, 133(9): 2023,e162309
Sakamoto T, Batmanov K, Wan S, Guo Y, Lai L, Vega RB, Kelly DP The nuclear receptor ERRgamma cooperates with the cardiogenic factor GATA4 to orchestrate cardiomyocyte differentiation , Nat Commun, 13(1): 2022,1991
Tomoya Sakamoto, Timothy R Matsuura, Shibiao Wan, David M Ryba, Junil Kim, Kyoung-Jae Won, Ling Lai, Christopher Petucci, Nataliya Petrenko, Kiran Musunuru, Rick B Vega, and Daniel P Kelly A Critical Role for Estrogen-related Receptor Signaling in Cardiac Maturation , Circulation Research: 2020
Gan Zhenji, Rumsey John, Hazen Bethany C, Lai Ling, Leone Teresa C, Vega Rick B, Xie Hui, Conley Kevin E, Auwerx Johan, Smith Steven R, Olson Eric N, Kralli Anastasia, Kelly Daniel P Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism. , The Journal of clinical investigation, 123(6): 2013,2564-75
Aubert Gregory, Martin Ola J, Horton Julie L, Lai Ling, Vega Rick B, Leone Teresa C, Koves Timothy, Gardell Stephen J, Krüger Marcus, Hoppel Charles L, Lewandowski E Douglas, Crawford Peter A, Muoio Deborah M, Kelly Daniel P The Failing Heart Relies on Ketone Bodies as a Fuel. , Circulation, 133(8): 2016,698-705