Charles S. Abrams, MD

Hematology
Accepting new patients
Sees patients age 18 and up
Penn Blood Disorders Center
Headshot of Charles S. Abrams, MD
Penn Medicine Provider

About me

  • Vice-Chair for Research and Chief Scientific Officer, Department of Medicine
  • Director, PENN-CHOP Blood Center for Patient Care & Discovery
  • Francis C. Wood Professor

My education and training

  • Medical School: Yale University School of Medicine
  • Residency: Temple University Hospital
  • Residency: University of Pennsylvania Health System
  • Fellowship: University of Pennsylvania Health System

Spoken languages

English
English

Reviews

Average Rating

124 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Anonymous
June 2026
dr abrams is the best
Anonymous
June 2026
very good to talk with and very helpful
Anonymous
June 2026
he was able to address certain puzzling issues that other practitioners could not convincingly and clearly.
Anonymous
May 2026
i feel confident to recommend dr abrams because he provides very good care and very knowledgeable.

Insurance accepted

Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.

Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
Dr. Abrams is a Penn Medicine physician.

Qualifications and experience

Treatments and conditions

Research

Publications

Wang, Y., Chen, X., Lian, L., Bach, T.L., Golden, J., Morrisey, E.M., Abrams, C.S. PIP5Kγ is required for cardiovascular and neuronal development , Proceedings of the National Academy of Science (U.S.A.), 104(28): 2007,11748-53


Trivedi, C.M., Luo, Y., Yin, Z., Zhang, M., Floss, T., Goettlicher, M., Ruiz, P., Wurst, W., Ferrari, V., Abrams, C.S., Gruber, P., Epstein, J.A. HDAC2 regulates the cardiac hypertrophic response by modulating GSK3β activity , Nature Medicine, 13: 2007,324-331


Wang, Y., Chen, X., Lian, L., Tang, T., Stalker, T.J., Sasaki, T., Brass, L.F., Choi, J.K., Hartwig, J.H., Abrams, C.S. Loss of PIP5KIβ demonstrates that rapid PIP2 synthesis is required for IP3 formation , Proceedings of the National Academy of Science (U.S.A.), 105: 2008,14064-14069


Pan, W., Choi, S.-C., Wang, H., Qin, Y., Volpicelli-Daley, L., Swan, L., Lucast, L., Khooo, C., Zhang, X., Li, L., Abrams, C.S., Sokol, S.Y., Wu, D. Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation , Science, 321: 2008,1350-1353


Wang, Y., Litvinov, R.I., Chen, X., Lian, L., Bach, T.L., Petrich, B., Monkley, S., Critchley, D., Birnbaum, M.J., Weisel, J.W., Hartwig, J.H., Abrams, C.S. Loss of PIP5Kγ, but not PIP5Kβ, impairs the integrity of the membrane cytoskeleton , J. Clinical Investigation, 118(2): 2008,812-819


Mao, Y.S., Yamaga, M., Zhu, X., Wei, M., Sun, H.-Q., Wang, J., Yun, M., Wang, Y., Di Paolo, G., Bennett, M., Mellman, I.S., Abrams, C.S., De Camilli, P.V., Lu, C.Y., and Yin, H.L. Essential and unique roles of PIP5Kγ and α in Fcγ receptor-mediated phagocytosis J. Cell Biology , Journal of Cell Biology, 184: 2009,281-296


Lian, L., Wang, W., Flick, M., Choi, J., Scott, E., Degen, J., Lemmon, M.A., Abrams, C.S. Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis , Blood, In press: 2009


Min, S.H., Abrams, C.S. Why do phosphatidylinositol kinases have so many isoforms? , Biochemical J, 423(1): 2009,99-108


Volpicelli-Daley, L.A., Lucast, L., Gong, L.-W., Liu, L., Sasaki, J., Sasaki, T., Abrams, C.S., Kanaho, Y., De Camilli, P. Phosphatidylinositol 4-phosphate 5-kinases (PIPKIs) and phosphatidylinositol 4,5 bisphosphate [PI(4,5)P2] synthesis in the brain. , J. Biologic Chemistry: 2010,28708-14


Mitsios, J.V., Prévost, N., Kasirer-Friede, A., Gutierrez, E., Groisman, A., Abrams, C.S., Litvinov, R.I., Zemljic-Harpf, A., Ross, R.S., Shattil, S., J. What is vinculin needed for in platelets? , J. Thrombosis & Haemostasis: 2010,2294-2304


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