Chafic Karam, MD
Neurology
Accepting new patients
Sees patients age 18 and up
Penn Neuroscience Center - Neurology
Headshot of Chafic Karam, MD
Penn Medicine Provider

About me

  • Chief, Neuromuscular Division
  • Professor of Clinical Neurology

Education and training

  • Medical School: Saint Joseph's University
  • Residency: Hotel Dieu de France
  • Residency: Mount Sinai Hospital
  • Residency: Mass General Brigham Healthcare Center - Chestnut Hill
  • Residency: Mayo Clinic

What my patients think about me

Average Rating

199 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

February 2026
my provider is knowledgeable; providing potential causes for my condition and referring me for further evaluation
January 2026
care about patients and providers professional services
January 2026
dr karam is kind and caring
January 2026
dr. karam addresses my medical concerns in a positive and caring manner

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
Dr. Karam is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Karam C. Clinical Utility of Serum Neurofilament Light Chain in Peripheral Neuropathy. , Muscle Nerve. : 2026,73(1):86-92.


Chakraborty R, Brailovsky Y, Hanna M, Witteles R, Vaishnav J, Hoffman JE, Griffin JM, Garcia-Pavia P, Wolinsky D, Karam C, Lachmann HJ, Gertz MA, Boursiquot BC, Bampatsias D, Hsu K, Johnson PT, Zigterman JL, Kazemzadeh AC, Maurer MS, Wechalekar AD. Prognostic Factors and Progression Biomarkers in AL Amyloidosis: Mapping Current Knowledge and Critical Gaps , Blood. 2026 Mar 4:blood.2025031651.: 2026


Fedak RR, Ruggerie RN, Shan Y, Curvino EJ, de Sousa JF, Daniel S, Ngo-Casi M, Kamboh H, Vu T, Durmuş H, Mozaffar T, Howard JF Jr, English EP, Benson A, Duvernay MT, Singer MS, Kalayoglu MV, Brunn C, Bodansky A, Anderson MS, DeRisi JL, Garcia ST, Yu DJL, Zorn KC, Kurtoglu M, Miljković MD, Stewart CA, Jewell CM; MG-001 Study Team. BCMA-directed mRNA CAR-T cell therapy for myasthenia gravis: exploratory biomarker analysis of a placebo-controlled phase 2b trial , Nat Med: 2026


Vu T, Durmus H, Rivner M, Shroff S, Ragole T, Myers B, Pasnoor M, Small G, Karam C, Vullaganti M, Peltier A, Sahagian G, Feinberg MH, Slanksy A, Barnett-Tapia C, Siddiqi Z, Gwathmey K, Badruddoja MA, Kamboh H, Ruggerie RN, Fedak RR, Stewart CA, Kurtoglu M, Kalayoglu M, Singer M, Jewell CM, Miljkovic MD, Dimachkie M, Mozaffar T, Howard JF Jr; MG-001 Study Team. BCMA-directed mRNA CAR T cell therapy for myasthenia gravis: a randomized, double-blind, placebo-controlled phase 2b trial , Nat Med. : 2026


Blein C, Karam C, Arvin-Berod C, Gelinas D, Barrera-Sierra S, Syed HUTA, Ward C, Goyal A, Guptill J. Real-world treatment utilization in adults with chronic inflammatory demyelinating polyneuropathy in the United States. , Front Neurol. 2026 Jan 29;16:1726857: 2026


Singh A, Wyatt J, Théaudin M, Karam C, Kasper D, Streubel B, Frascello K, Bondue A. Effectiveness and Utility of Genetic Testing in Establishing a Diagnosis of Hereditary Transthyretin Amyloidosis , Journal of Clinical Medicine.: 2025


Khandelwal N, Sanchirico M, Ajibade A, Munshi K, Vu M, Engel-Nitz N, Steiger C, Anderson AJ, Karam C. Characteristics, Treatment Patterns, Healthcare Resource Utilization, and Costs Among Patients with Multifocal Motor Neuropathy: A US Claims Database Cohort Study , J Health Econ Outcomes Res. 2025 Jun 26;12(1):261-268. : 2025


Hsu RT, Wilson J, Karam C. Amyloid Spikes on Optical Coherence Tomography Demonstrating Ocular Involvement in ATTRv Amyloidosis , Neurology. : 2025


Bril V, Drużdż A, Grosskreutz J, Habib AA, Kaminski HJ, Mantegazza R, Sacconi S, Utsugisawa K, Vu T, Boehnlein M, Gayfieva M, Greve B, Woltering F, Vissing J; MG0004 study investigators. Safety and efficacy of chronic weekly rozanolixizumab in generalized myasthenia gravis: the randomized open-label extension MG0004 study. , J Neurol.: 2025


Morganroth J, Karam C. Anti-Myelin-Associated Glycoprotein Neuropathy: Recent Developments , Neurol Clin Pract. : 2025


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