Carla R. Scanzello, MD, PhD
Penn Medicine Provider

About me

  • Associate Professor of Medicine (Rheumatology) at the Hospital of the University of Pennsylvania
  • Associate Professor of Medicine in Orthopaedic Surgery

Insurance accepted

My Locations

Qualifications and experience

Treatments and Conditions

My research

Q Wang, AL Rozelle, CM Lepus, CR Scanzello, JJ Song, DM Larsen, JF Crish, G Bebek, SY Ritter, TM Lindstrom, I Hwang, HH Wong, L Punzi, A Encarnacion, M Shamloo, SB Goodman, T Wyss-Coray, SR Goldring, R Gobezie, MK Crow, VM Holers DM Lee, WH Robinson Identification of a central role for complement in osteoarthritis , Nature Medicine, 17(12): 2011,1674-9


Nair A, Gan J, Bush-Joseph C, Verma N, Tetreault MW, Saha K, Margulis A, Fogg L, Scanzello CR. Synovial chemokine expression and relationship with knee symptoms in patients with meniscal tears. , Osteoarthritis Cartilage, 23(7): 2015,1158-64


Sambamurthy Nisha, Nguyen Vu, Smalley Ryan, Xiao Rui, Hankenson Kurt, Gan Justin, Miller Rachel E, Malfait Anne-Marie, Dodge George R, Scanzello Carla R Chemokine receptor-7 (CCR7) deficiency leads to delayed development of joint damage and functional deficits in a murine model of osteoarthritis. , Journal of orthopaedic research, 36(3): 2018,864-87


Sambamurthy Nisha, Zhou Cheng, Nguyen Vu, Smalley Ryan, Hankenson Kurt D, Dodge George R, Scanzello Carla R Deficiency of the pattern-recognition receptor CD14 protects against joint pathology and functional decline in a murine model of osteoarthritis. , PloS One, 13(11): 2018,e0206217


S Kolasinski, T Neogi, M Hochberg, C Oatis, GH Guyatt, J Block, L Callahan, C Copenhaver, C Dodge, D Felson, K Geller, W Harvey, G Hawker, E Herzig, K Kwoh, A Nelson, J Samuels, C Scanzello, D White, B Wise, R Altman, D DiRenzo, J Fontanarosa, G Giradi, M Ishimori, D Misra, A Shah, A Shmagel, L Thoma, M Turgunbaev, A Turner, J Reston. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip and Knee. , Arthritis & Rheumatology, 72(2): 2020,220-233


S Bansal, KD Meadows, LM Miller, KS Saleh, JM Patel, BD Stoeckl, EA Lemmon, MW Hast, MH Zgonis, CR Scanzello, DM Elliott, RL Mauck Six Month Outcomes of Clinically Relevant Meniscal Injury in a Large Animal Model , Orthopaedic Journal of Sports Medicine, 9(11): 2021,23259671211035444


CR Scanzello, KA Hasty, CB Chung, TM Griffin, NJ Willet, H Krug, Cong-Qiu Chu, D Ewart, S Jerban, JF Baker, CL Duvall, JM Brunger, JA Burdick, KP Spindler, H Drissi. Teaming Up to Overcome Challenges in the Clinical Translation of New Therapeutics for Osteoarthritis. , J Ortho Res, 42(12): 2024,2659-2672.


AM Obeidat, SY Kim, KG Burt, B Hu, J Li, S Ishihara, R Xiao, RE Miller, C Little, AM Malfait, CR Scanzello A standardized approach to evaluation and reporting of synovial histopathology in two surgically induced murine models of osteoarthritis , Osteoarthritis Cartilage., 32(10): 2024,1273-1282


SY Kim, CR Scanzello When “Synovitis” isn’t Synovitis. , Osteoarthritis Cartilage , 33(1): 2025,1-4


LA Murphy, CR Scanzello. Cellular and molecular mechanisms underlying subchondral bone remodeling and associated pain in osteoarthritis. , Connect Tissue Res. : 2025


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