Bruce L. Levine, PhD
Sees patients age 18 and up
Penn Pathology and Laboratory Medicine HUP
Penn Medicine Provider

About me

  • Barbara and Edward Netter Professor in Cancer Gene Therapy

Insurance accepted

My Locations

Qualifications and experience

Treatments and Conditions

My research

Ramírez-Fernández Á, Dimitri AJ, Chen F, Bartoszek R, Chen GM, Córdoba-Espejo L, Zhou Y, Tang YH, Lin CT, Acosta R, Scholler J, Ghilardi G, Porazzi P, Pellicer M, Profitós-Pelejà N, Barta SK, Chew A, Jadlowsky JK, Gonzalez VE, Siegel DL, Levine BL, Roué G, Ruella M, Lotze MT, June CH, Riley JL, Fraietta JA. CCR5-targeted allogeneic gamma-delta CD19 chimeric antigen receptor T cells for HIV-associated B cell-malignancy immunotherapy , Nat Biomed Eng: 2025


Golinelli G, Scholler J, Roussel-Gervais A, Šakić A, Ilmjärv S, Song D, Gabunia K, Ji M, Fan TJ, Gupta A, Deshmukh M, Berjis A, Cuoghi Costantini R, Apodaca K, Sheppard NC, Kili S, Dominici M, Alessandrini M, June CH, Levine BL. Multiplex engineering using microRNA-mediated gene silencing in CAR T cells , Front Immunol, 16: 2025,1647433


Svoboda J, Landsburg DJ, Gerson J, Nasta SD, Barta SK, Chong EA, Cook M, Frey NV, Shea J, Cervini A, Marshall A, Four M, Davis MM, Jadlowsky JK, Chew A, Pequignot E, Gonzalez V, Noll JH, Paruzzo L, Rojas-Levine J, Plesa G, Scholler J, Siegel DL, Levine BL, Porter DL, Ghassemi S, Ruella M, Rech A, Leskowitz RM, Fraietta JA, Hwang WT, Hexner E, Schuster SJ, June CH. Enhanced CAR T-Cell Therapy for Lymphoma after Previous Failure , N Engl J Med, 392: 2025,1824-1835


Obiozor CC, Day LW, Dube B, Edrah IE, Uzoka E, June CH, Levine BL, Sammut SM Cellular gene therapy access in Africa: a multifactorial feasibility analysis for implementation , Cytotherapy: 2025


Jadlowsky JK, Hexner EO, Marshall A, Grupp SA, Frey NV, Riley JL, Veloso E, McConville H, Rogal W, Czuczman C, Hwang WT, Li Y, Leskowitz RM, Farrelly O, Karar J, Christensen S, Barber-Rotenberg J, Gaymon A, Aronson N, Bernstein W, Melenhorst JJ, Roche AM, Everett JK, Zolnoski SA, McFarland AG, Reddy S, Petrichenko A, Cook EJ, Lee C, Gonzalez VE, Alexander K, Kulikovskaya I, Ramírez-Fernández Á, Minehart JC, Ruella M, Gill SI, Schuster SJ, Cohen AD, Garfall AL, Shah PD, Porter DL, Maude SL, Levine BL, Siegel DL, Chew A, McKenna S, Lledo L, Davis MM, Plesa G, Herbst F, Stadtmauer EA, Tebas P, DiNofia A, Haas A, Haas NB, Myers R, O'Rourke DM, Svoboda J, Tanyi JL, Aplenc R, Jacobson JM, Ko AH, Cohen RB, June CH, Bushman FD, Fraietta JA. Long-term safety of lentiviral or gammaretroviral gene-modified T cell therapies , Nature Medicine, 31(4): 2025,1134-1144


Dimitri AJ, Baxter AE, Chen GM, Hopkins CR, Rouin GT, Huang H, Kong W, Holliday CH, Wiebking V, Bartoszek R, Drury S, Dalton K, Koucky OM, Chen Z, Giles JR, Dils AT, Jung IY, O'Connor R, Collins S, Everett JK, Amses K, Sherrill-Mix S, Chandra A, Goldman N, Vahedi G, Jadlowsky JK, Young RM, Melenhorst JJ, Maude SL, Levine BL, Frey NV, Berger SL, Grupp SA, Porter DL, Herbst F, Porteus MH, Carty SA, Bushman FD, Weber EW, Wherry EJ, Jordan MS, Fraietta JA. TET2 regulates early and late transitions in exhausted CD8(+) T cell differentiation and limits CAR T cell function , Sci Adv, 10: 2024,eadp9371


Pablo Tebas, Julie K Jadlowsky, Pamela A Shaw, Lifeng Tian, Erin Esparza, Andrea L Brennan, Sukyung Kim, Soe Yu Naing, Max W Richardson, Ashley N Vogel, Colby R Maldini, Hong Kong, Xiaojun Liu, Simon F Lacey, Anya M Bauer, Felicity Mampe, Lee P Richman, Gary Lee, Dale Ando, Bruce L Levine, David L Porter, Yangbing Zhao, Don L Siegel, Katharine J Bar, Carl H June, James L Riley CCR5-edited CD4+ T cells augment HIV-specific immunity to enable post-rebound control of HIV replication , Journal of Clinical Investigation, 134(9): 2024,e181576


Ghilardi G, Fraietta JA, Gerson JN, Van Deerlin VM, Morrissette JJD, Caponetti GC, Paruzzo L, Harris JC, Chong EA, Susanibar Adaniya SP, Svoboda J, Nasta SD, Ugwuanyi OH, Landsburg DJ, Fardella E, Waxman AJ, Chong ER, Patel V, Pajarillo R, Kulikovskaya I, Lieberman DB, Cohen AD, Levine BL, Stadtmauer EA, Frey NV, Vogl DT, Hexner EO, Barta SK, Porter DL, Garfall AL, Schuster SJ, June CH, Ruella M. T cell lymphoma and secondary primary malignancy risk after commercial CAR T cell therapy , Nat Med: 2024


Wang K, Tseng CY, Li Z, White C, Wang B, Levine BL, Fesnak AD. A simulation-based comparison of centralized and point-of-care supply chain strategies for autologous cell therapy , Cytotherapy, 25(12): 2023,1370-1379


Bobisse S, Bianchi V, Tanyi JL, Sarivalasis A, Missiaglia E, Pétremand R, Benedetti F, Torigian DA, Genolet R, Barras D, Michel A, Mastroyannis SA, Zsiros E, Dangaj Laniti D, Tsourti Z, Stevenson BJ, Iseli C, Levine BL, Speiser DE, Gfeller D, Bassani-Sternberg M, Powell DJ Jr, June CH, Dafni U, Kandalaft LE, Harari A, Coukos G. A phase 1 trial of adoptive transfer of vaccine-primed autologous circulating T cells in ovarian cancer , Nat Cancer: 2023