Anupma Nayak, MD

Pathology and Laboratory Medicine
Sees patients age 18 and up
Penn Pathology and Laboratory Medicine HUP
Headshot of Anupma Nayak, MD
Penn Medicine Provider

About me

  • Associate Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania

My areas of clinical expertise:

Breast Pathology

Genitourinary Pathology

My education and training

  • Medical School: King George's Medical University
  • Residency: All India Institute of Medical Sciences
  • Residency: Long Island Jewish Medical Center
  • Fellowship: All India Institute of Medical Sciences
  • Fellowship: Texas Medical Center

Spoken languages

English
English

Insurance accepted

Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.

Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
Dr. Nayak is a Penn Medicine physician.

Qualifications and experience

Treatments and conditions

Research

Publications

Boruah N, Hoyos D, Moses R, Hausler R, Desai H, Le AN, Good M, Kelly G, Raghavakaimal A, Tayeb M, Narasimhamurthy M, Doucette A, Gabriel P, Feldman MJ, Park J, Lopez de Rodas M, Schalper KA, Goldfarb SB, Nayak A, Levine AJ, Greenbaum BD, Maxwell KN. Distinct genomic and immunologic tumor evolution in germline TP53-driven breast cancers. , Nat Commun. , 17(1): 2026,7300


Sreekumar A, Blankemeyer E, Sterner CJ, Pan TC, Pant DK, Acolatse S, Turkistani H, Belka GK, Nayak A, Carlin SD, Assenmacher CA, Sellmyer MA, Mankoff DA, Chodosh LA. Residual Breast Cancer Cells Co-opt SOX5-Driven Endochondral Ossification to Maintain Dormancy. , Cancer Discov.: 2026,781-799


Akamandisa MP, Xia M, Cheah W, Wubbenhorst B, D'Andrea KP, Fan M, Shilan JS, Pueschl D, Nayak A, McKenzie H, Tapper W, Copson ER, Cutress RI, Domchek SM, Eccles DM, Nathanson KL. Comparative analysis of distinct genomic landscapes in young-onset gBRCA1/2 breast cancer. , JCI Insight, 11(12): 2026,e203005.


Budina A, Vergara N, Navarro FE, Morrissette JJD, Nayak A. High-Grade Urothelial Carcinoma with Divergent Prostatic Differentiation Mimicking a Collision Tumor in a Bladder Diverticulum. Int J Surg Pathol. 2026 Mar 31:10668969261429079. doi: 10.1177/10668969261429079. Epub ahead of print. PMID: 41918088. High-Grade Urothelial Carcinoma with Divergent Prostatic Differentiation Mimicking a Collision Tumor in a Bladder Diverticulum. , Int J Surg Pathol. : 2026


Yuan M, Jin K, Yan H, Schroeder A, Luo C, Yao S, Dumoulin B, Levinsohn J, Luo T, Clemenceau JR, Jang I, Kim M, Liu Y, Deng M, Furth EE, Wilson P, Nayak A, Lubo I, Solis Soto LM, Wang L, Park JH, Susztak K, Hwang TH, Li M. Smart spatial omics (S2-omics) optimizes region of interest selection to capture molecular heterogeneity in diverse tissues. , Nat Cell Biol., 27(12): 2025,2225-2238


DeMichele A, Clark A, Shea E, Bayne L, Sterner C, Rohn K, Eberle-Dwyer S, Pan T-C, Nivar I, Chen Y, Wileyto EP, Berry L, DeLuca S, Savage J, Makhlin I, Pant D, Egunsola A, Mears N, Goodspeed B, Chislock E, Graves J, Wang J, Shih N, Belka G, Berry D, Nayak A, Feldman M, Martin H, Chodosh L. Targeting Dormant Tumor Cells to Prevent Recurrent Breast Cancer: a randomized phase 2 trial. , Nature Medicine: 2025


Griffin B. Spychalski1, Andrew A. Lin, Stephanie J. Yang, Hanfei Shen, Jean Rosario, Kyle Tien, Kate French, Miriyam Ghali, Stephanie Yee, Melinda Yin, Michael D. Feldman, Emily F. Conant, Susan P. Weinstein, Erica L. Carpenter, David Issadore, Anupma Nayak miRNA Panel from HER2+ and CD24+ Plasma Extracellular Vesicle Subpopulations as Biomarkers of Early-stage Breast Cancer , Breast Cancer Res., 27(1): 2025,90


Narasimhamurthy M, Le A, Boruah N, Moses R, Kelly G, Bleiweiss I, Maxwell KN, Nayak A. Clinicopathologic Features of Breast Tumors in Germline TP53 Variant-Associated Li-Fraumeni Syndrome. , Am J Surg Pathol., 49(3): 2025,195-205


Kaitlin Demarest, Arravinth Anantharajah, Kara N. Maxwell1, Mersedeh Rohanizadegan, Angela Bradbury, Katherine L Nathanson, Susan Domchek, Anupma Nayak, Payal D. Shah Pathogenic Germline Variants in Patients with Metaplastic Breast Cancer , JAMA Network Open , 8(2): 2025


Young AJ, Pantel AR, Kiani M, Doot RK, Bagheri S, Pryma DA, Farwell MD, Li S, Lee H, Schubert EK, Secreto A, Zuckerman SP, Nayak A, Choi H, Carlin S, DeMichele A, Mankoff DA, Zhou R, Mach RH, McDonald ES. Kinetic Analysis and Metabolism of Poly(Adenosine Diphosphate-Ribose) Polymerase-1-Targeted 18F-Fluorthanatrace PET in Breast Cancer. , J Nucl Med. , 65((12)): 2024,1862-68


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