Amrit S. Khalsa, MD
Orthopaedic Surgery
Headshot of Amrit S. Khalsa, MD
Schedule onlineCall 215-662-3340

Amrit S. Khalsa, MD

Orthopaedic Surgery
Accepting new patients
Sees patients age 14 and up
Penn Orthopaedics University City - 8th Floor
View 4 additional locations
Schedule onlineCall 215-662-3340
Headshot of Amrit S. Khalsa, MD
Penn Medicine Provider

About me

  • Co-Director, Spine Surgery Fellowship
  • Chief, Spine Division
  • Associate Professor of Clinical Orthopaedic Surgery

Dr. Khalsa diagnoses and treats conditions of the back and neck ranging from athletic injuries to arthritis and scoliosis. He offers a wealth of non-operative and conservative options. He has expertise in both minimally invasive and complex spine surgery techniques, including artificial disc replacement and complex revision surgery. He was recognized in the 2025 Mainline Region Top Doctors in Orthopedics: Spine surgery.

My education and training

  • Tulane University School of MedicineMedical School
  • Drexel University College of MedicineResidency
  • Scripps Green HospitalFellowship
Watch video featuring Amrit S. Khalsa, MD on YouTube

Spoken languages

English
English

Reviews

Average Rating

1107 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Anonymous
August 2026
dr khalsa makes you feel comfortable and gives you a generous amount of time to go over diagnosis and treatment options.
Anonymous
August 2026
very thorough
Anonymous
August 2026
he answered all our ??
Anonymous
August 2026
dr khalsa is very empathetic

Insurance accepted

Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.

Locations

PRIMARY LOCATION
215-662-3340
Learn about location
215-662-3340
Learn about location
215-662-3340
Learn about location
800-789-7366
Learn about location

Penn Medicine hospital privileges

  • Chester County Hospital: Has privileges to treat patients in the hospital.
  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
Dr. Khalsa is a Penn Medicine physician. In New Jersey, providers are affiliated with Penn Medicine through Clinical Health Care Associates of New Jersey or Princeton Healthcare Affiliated Physicians, PC.

Qualifications and experience

Treatments and conditions

Research

Publications

Moser AM, Anaspure OS, Peregoff J, Hassan Z, Assefa T, Okorie N, Casper D, Khalsa A. Examining the Outcomes of Multilevel Thoracolumbar Instrumented Fusion Constructs With Concomitant Sacroiliac Joint Fusion Using S2-Alar-Iliac Screws: A Systematic Review. , Clin Spine Surg.: 2026

Omkar S Anaspure, Aryan S Anaspure, Anthony N Baumann, Tensae Assefa, Nnaemeka Okorie, David Casper, Amrit S Khalsa Answer to Letter to the Editor concerning "Interbody cage use on successful spinal correction in pedicle subtraction osteotomy for adult spinal deformity surgery: a systematic review and meta-analysis of comparative studies" , Spine Deformity: 2026

Anaspure OS, Anaspure AS, Baumann AN, Assefa T, Okorie N, Casper D, Khalsa AS. Interbody cage use on successful spinal correction in pedicle subtraction osteotomy for adult spinal deformity surgery: a systematic review and meta-analysis of comparative studies , Spine Deformity: 2026

Khalsa A, Peregoff J, Turlip RW, Zemberi J, Capone G, Kwon M, Moser A, Uzosike O, Hassan Z, Cieplik NM, Assefa T, Okorie N, Casper D. AI-Assisted, Literature-Informed Development and Retrospective Validation of a Point-Based Surgical Site Infection Risk Calculator for Spine Surgery. , Global Spine J.: 2026

Mastrokostas PG, Mastrokostas LE, Emara AK, Wellington IJ, Ginalis E, Houten JK, Khalsa AS, Saleh A, Monsef JB, Razi AE, Ng MK. Increasing public interest in lumbar decompression and fusion surgery in the United States: higher search volumes in the Northeast region from 2015 to 2024. , Asian Spine J.: 2025

Mastrokostas PG, Mastrokostas LE, Emara AK, Salman M, Wellington IJ, Ginalis E, Dalton J, Houten JK, Khalsa AS, Saleh A, Monsef JB, Razi AE, Ng MK. A step-by-step guide for designing systematic reviews in spine surgery: a narrative review. , J Spine Surg.: 2025

Mastrokostas PG, Mastrokostas LE, Emara AK, Salman M, Wellington IJ, Ginalis E, Dalton J, Houten JK, Khalsa AS, Saleh A, Razi AE, Ng MK. GPT-4 as a source of patient information for cervical disc arthroplasty: a comparative analysis against Google web search. , J Spine Surg: 2025

Peregoff J, Anaspure OS, Moser A, Hassan Z, Baumann AN, Assefa T, Okorie N, Casper D, Khalsa AS. Postoperative Ketorolac Administration and Pseudoarthrosis Following Multilevel Posterior Cervical Decompression and Fusion: A Retrospective Cohort Study. , Spine (Phila Pa 1976), 4: 2025,doi: 10.1097/BRS.0000000000005493

Okorie N, Peregoff J, Osemwengie B, Casper D, Khalsa A. Comparative outcomes of anterior versus posterior fixation in odontoid fractures: A longitudinal population-based analysis. , J Orthop., 18(70): 2025,247-251

Mastrokostas PG, Mastrokostas LE, Emara AK, Wellington IJ, Ginalis E, Houten JK, Khalsa AS, Saleh A, Monsef JB, Razi AE, Ng MK. Increasing public interest in lumbar decompression and fusion surgery in the United States: higher search volumes in the Northeast region from 2015 to 2024. , Asian Spine J., 11: 2025,doi: 10.31616/asj.2025.0133