Alex G. Lambi, MD, PhD, FACS

Plastic Surgery, Orthopaedic Surgery
Accepting new patients
Sees patients age 18 and up
Penn Plastic Surgery Perelman
Make an appointmentCall 215-662-7300
Penn Medicine Provider

About me

  • Associate Director of Research, Division of Plastic Surgery
  • Chief, Plastic Surgery, Corporal Michael J. Crescenz, VA Medical Center
  • Assistant Professor of Surgery at the Hospital of the University of Pennsylvania

Alex G. Lambi, MD, PhD, FACS is a board-certified plastic surgeon with subspecialty certification in hand surgery. His practice integrates plastic surgery and orthopaedic hand surgery to provide comprehensive care for disorders of the hand, wrist, forearm, peripheral nerves, and soft tissues.

Dr. Lambi specializes in hand and upper extremity surgery, including peripheral nerve disorders, carpal tunnel syndrome, cubital tunnel syndrome, Dupuytren disease, trigger finger, arthritis, fractures, tendon disorders, soft tissue masses, skin cancer reconstruction, and complex upper extremity reconstruction. His clinical practice is based at Penn Medicine and the Corporal Michael J. Crescenz VA Medical Center. He is committed to providing individualized care that combines the latest evidence-based treatments with thoughtful discussion of both surgical and nonsurgical options.

As a surgeon-scientist, Dr. Lambi leads a translational research program focused on fibrosis and musculoskeletal disorders affecting the upper extremity. His research integrates clinical investigation, advanced imaging, genetics, tissue biology, and patient-centered outcomes research to develop improved diagnostics and therapies for conditions including Dupuytren disease, peripheral nerve compression, trigger finger, radiation-induced fibrosis, and connective tissue disorders.

My education and training

  • Medical School: Temple University School of Medicine
  • Residency: David Geffen School of Medicine at UCLA
  • Fellowship: University of New Mexico Hospitals

Spoken languages

English
English

Insurance accepted

Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.

Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
Dr. Lambi is a Penn Medicine physician.

Qualifications and experience

Treatments and conditions

Research

Publications

Lambi AG, Holy T, Tomlinson RE, Barbe MF. Radiation-Induced Brachial Plexopathy: Current Understanding, Diagnosis, and Treatment Options , J Hand Surg Glob Online, 8: 2025,100896

Barbe, M.F., Lambi, A.G., Harris, M.Y., Patel, P.R., Tamas, I.P., Mcgonagle, E.R., Megan, V.D.B., Kalicharan, B.A., Holt-Bright, L., Popoff, S.N, Klyne, D.M. Repetitive Strain Injury-Induced Discomfort and Social Behaviors are Associated with Increased IL-6 in Musculoskeletal Tissues, Serum, and Brain , Frontiers in Physiology, 16:16: 2025,1500795

Patel, P.R., Lambi, A.G., Shetty, A., Tamas, I.P., Popoff, S.N., Barbe, M.F. Distal Forepaw Muscle Fibrosis and Entheseal Damage in a Repetitive Overuse Injury Model , Plast Reconstr Surg Glob Open, S1: 2025,102-103

Patel PR, Tamas IP, Van Der Bas M, Kegg A, Hilliard BA, Lambi AG, Popoff SN, Barbe MF. Repetitive Overuse Injury Causes Entheseal Damage and Palmar Muscle Fibrosis in Older Rats , Int J Mol Sci, 25: 2024,13546

Lambi AG, DeSante RJ, Patel PR, Hilliard BA, Popoff SN, Barbe MF. Blocking CCN2 Reduces Established Palmar Neuromuscular Fibrosis and Improves Function Following Repetitive Overuse Injury , Int J Mol Sci, 24: 2023,13866

Lambi AG, Rowland RJ, Brady NW, Rodriguez DE, Mercer DM. Metacarpal fractures , J Hand Surg Eur Vol, 48;2: 2023,42S-50S

Lambi AG, Popoff SN, Benhaim P, Barbe MF. Pharmacotherapies in Dupuytren Disease: Current and Novel Strategies , J Hand Surg Am, 48(8): 2023,810-821

Lambi AG, Morrell NT, Popoff SN, Benhaim P, Barbe MF. Let's Focus on the Fibrosis in Dupuytren Disease: Cell Communication Network Factor 2 as a Novel Target , J Hand Surg Glob Online, 5: 2023,682-688

Lambi AG, Harris MY, Amin M, Joiner PG, Hilliard BA, Assari S, Popoff SN, Barbe MF. Blocking CCN2 Reduces Established Bone Loss Induced by Prolonged Intense Loading by Increasing Osteoblast Activity in Rats , JBMR Plus, 7: 2023,e10783

Lambi, A.G., Morrell, N.T., Popoff, S.N., Benhaim, P., Barbe, M.F. Let’s Focus on the Fibrosis in Dupuytren Disease: CCN2 as a Novel Target , J Hand Surg Glob Online , 5(5): 2023,682-688