PHILADELPHIA — Penn Medicine has entered into a new strategic collaboration with BioNTech, a German biotechnology company, to research and develop mRNA vaccines for various infectious diseases.
The goal of the multi-year partnership is for researchers from both the Perelman School of Medicine at the University of Pennsylvania and BioNTech to exchange their in-depth knowledge and experience in mRNA research and development to advance the discovery of novel vaccine candidates for up to 10 infectious diseases.
At Penn, the research will be conducted by Drew Weissman, MD, PhD, a professor of Infectious Diseases, as well other investigators, including Gary H. Cohen, PhD, a professor of Microbiology, and Harvey Friedman, MD, a professor of Infectious Diseases.
While most commercially available vaccines for infectious diseases involve a lab-grown inactivated or attenuated virus that is injected into the body to elicit an immune response for future protection, mRNA vaccines work by delivering nucleotide sequences that code for specific cell surface antigens found on pathogens. Once the mRNA vaccine enters the body’s cells, it uses cellular machinery to produce the cell surface antigen protein encoded by the mRNA. The antigen is then recognized as foreign by the immune system, eliciting a strong response for protection against the target pathogen.
“Nucleoside-modified mRNA vaccines offer promising advantages over conventional vaccines: They have the potential to encode any antigen for almost any pathogen and allow for higher levels of neutralization and durability of the response, and a capacity for faster production at a lower cost,” Weissman said. “Combining Penn’s strengths in immunotherapy, molecular biology, and mRNA expertise with BioNTech’s technology platforms could lead to the development of highly flexible vaccines that provide protections against a wide-ranging list of infectious diseases.”
Recent research led by Weissman has demonstrated the potential of mRNA to elicit potent immune responses against pathogens, including influenza and Zika virus, making it a viable and attractive platform for prophylactic vaccine development. A study in Nature Communications in August 2018 by Weissman and colleagues showed how an mRNA vaccine elicited a strong antibody response to a structure on the surface of flu viruses, called the hemagglutinin stalk, and protected mice from infection by distant and mutated flu strains.
The new vaccine research will focus on infectious diseases with a large unmet need, a growing epidemic potential, or that have remained inaccessible to conventional vaccine approaches.
“Entering into a strategic R&D alliance with BioNTech expands the infectious disease research efforts at Penn,” said James W. Bowen, PhD, the executive director of Corporate Alliances at the Penn Center for Innovation. “This alliance builds on a strong foundation of mRNA engineering and vaccine development knowledge and aligns this Penn expertise with the mRNA manufacturing, mRNA product development, and translational science capabilities of BioNTech. We welcome collaboration and innovation that improves vaccine development with a goal to develop new and improved ways to reduce the transmission of infectious diseases.”
Penn Medicine is one of the world’s leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System, which together form a $7.8 billion enterprise.
The Perelman School of Medicine has been ranked among the top medical schools in the United States for more than 20 years, according to U.S. News & World Report’s survey of research-oriented medical schools. The School is consistently among the nation’s top recipients of funding from the National Institutes of Health, with $405 million awarded in the 2017 fiscal year.
The University of Pennsylvania Health System’s patient care facilities include: The Hospital of the University of Pennsylvania and Penn Presbyterian Medical Center — which are recognized as one of the nation’s top “Honor Roll” hospitals by U.S. News & World Report — Chester County Hospital; Lancaster General Health; Penn Medicine Princeton Health; Penn Wissahickon Hospice; and Pennsylvania Hospital – the nation’s first hospital, founded in 1751. Additional affiliated inpatient care facilities and services throughout the Philadelphia region include Good Shepherd Penn Partners, a partnership between Good Shepherd Rehabilitation Network and Penn Medicine, and Princeton House Behavioral Health, a leading provider of highly skilled and compassionate behavioral healthcare.
Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2017, Penn Medicine provided $500 million to benefit our community.