Driving Directions

The Hospital of the University of Pennsylvania (HUP) is located at 34th and Spruce Streets. The address is 3400 Spruce Street, Philadelphia, PA 19104. The main entrance of the hospital and valet parking are is located on 34th Street.

The Eastbound and Westbound ramps to I-76 South Street are closed until the end of 2020. Valet service is temporarily suspended to limit COVID-19 exposure. 

Directions to the main entrance of HUP:

• From Northeastern Areas:
  From I-95 South, take the Vine Street/Center City Exit, stay left to 676 West (Vine Street Express-way). Follow 676 West to the I-76 East Exit 1, International Airport. Follow I-76 East (Schuylkill Expressway) to Exit 346B, University Avenue. Continue on University Avenue, and then turn right onto Civic Center Boulevard. Turn right onto Health Sciences Drive. Turn left on S. Convention Avenue. Turn right on 33rd Steet. Turn left on Spruce Street. Turn left on S. 34th St. HUP is on your right. See parking directions.

• From the West & Montgomery County
  Take the Pennsylvania Turnpike to Exit 326, Valley Forge. Take I-76 East (Schuylkill Expressway) approximately 17 miles to Exit 346B, University Avenue. Continue on University Avenue, and then turn right onto Civic Center Boulevard. Turn right onto Health Sciences Drive. Turn left on S. Convention Avenue. Turn right on 33rd Steet. Turn left on Spruce Street. Turn left on S. 34th St. HUP is on your right. See parking directions

• From the North
  Take I-476 (Northeast Extension) South to Exit 20, Mid-County. Pay the toll and continue south on I-476 to Exit 16A, I-76 East. Follow I-76 East (Schuylkill Expressway) approximately 17 miles to Exit 346B, University Avenue. Continue on University Avenue, and then turn right onto Civic Center Boulevard. Turn right onto Health Sciences Drive. Turn left on S. Convention Avenue. Turn right on 33rd Steet. Turn left on Spruce Street. Turn left on S. 34th St. HUP is on your right. See parking directions

• From the South/Philadelphia International Airport
  Take I-95 North to Exit 13, PA-291 toward I-76 West/Valley Forge (Schuylkill Expressway). Merge right. Cross Girard Point Bridge and turn left at light on 26th Street. Merge on I-76 West to Exit 346B, University Avenue. Continue on University Avenue, and then turn right onto Civic Center Boulevard. Turn right onto Health Sciences Drive. Turn left on S. Convention Avenue. Turn right on 33rd Steet. Turn left on Spruce Street. Turn left on S. 34th St. HUP is on your right. See parking directions

• From New Jersey
  Take I-295 to the Walt Whitman Bridge. Follow signs for I-76 West (Schuylkill Expressway) and take Exit 346B, University Avenue. Continue on University Avenue, and then turn right onto Civic Center Boulevard. Turn right onto Health Sciences Drive. Turn left on S. Convention Avenue. Turn right on 33rd Steet. Turn left on Spruce Street. Turn left on S. 34th St. HUP is on your right. See parking directions

• From Philadelphia International Airport

  • Driving: All major car rental companies are located at the airport.
  • Airport Train: The train leaves every half hour at 10 minutes and 40 minutes past the hour, and it arrives at University City Station on the HUP campus. The train costs approximately $5 and takes 20 minutes.
    • Schedules: PDF | Map
    • To Center City Philadelphia: Weekdays | Saturdays | Sundays
    • To Philadelphia International Airport: Weekdays | Saturdays | Sundays
  • Taxi: A metered cab from the airport costs approximately $20 and the ride takes approximately 20 minutes.

Download campus map with driving directions and parking information (PDF)