The Penn Comprehensive MS Center is made up of experienced, highly-trained clinicians, researchers and educators who are experts in the diagnosis and management of MS.

This program is a part of the top-ranked Penn Neurosciences and offers patients access to the latest research advancements in MS.

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MS patient

Penn clinicians at the Penn Comprehensive Multiple Sclerosis (MS) Center provide evaluation, diagnosis and treatment for patients with multiple sclerosis (MS) and associated disorders, including optic neuritis (inflammation of the optic nerves), transverse myelitis (inflammation of the spinal cord), neuromyelitis optica, acute disseminated encephalomyelitis, and other autoimmune conditions of the central nervous system (CNS).

The Penn Comprehensive MS Center is located at the Hospital of the University of Pennsylvania (HUP). Members of the MS Division also staff clinics at Pennsylvania Hospital and Penn Presbyterian Medical Center.

Multiple sclerosis (MS) is an immune-mediated disease affecting the central nervous system (the brain and spinal cord). There are more than 450,000 people in the United States with MS, making it one of the most common causes of neurological disability among young adults in North America. Although MS can appear at any age, it most commonly becomes clinically-apparent between the ages of 20 and 40, and affects women twice as often as men.

Symptoms of MS

As virtually any region of the central nervous system may be affected by MS, the symptoms of MS are quite varied. Approximately 50 percent of patients with MS first present with an isolated neurological problem and an almost equal number have more than one symptom heralding their illness.

Relapses or the exacerbation of symptoms in MS can last for days or weeks and then resolve, partially or fully. Over time, symptoms may persist or steadily worsen, as part of progressive disease Symptoms of multiple sclerosis may occur in varying degrees of intensity, ranging from mild to severe. Among the most common symptoms of MS are:

  • Visual loss
  • Double vision
  • Vertigo
  • Weakness of one or more extremities
  • Facial weakness
  • Trigeminal neuralgia (facial pain)
  • Numbness and tingling
  • Muscle stiffness (spasticity)
  • Gait abnormalities and imbalance
  • Cognitive difficulties
  • Depression
  • Fatigue
  • Bowel and bladder problems
  • Sexual dysfunction
  • Pain

In 2014, the National MS Society designated the Penn MS Center as a National MS Comprehensive Care Center. This achievement recognizes the ability of the Penn MS Center to provide comprehensive, state-of-the-art care to patients with MS, while also contributing to important research advances.

As a multispecialty program, our team of physicians, nurses, nurse practitioners, pharmacists, physical and occupational therapists, and social workers collaborate with experts across multiple disciplines to provide diagnosis, care and management of MS and associated disorders. The Penn Comprehensive MS Center also works with the local chapters of the National MS Society and Multiple Sclerosis Association of America to assure the highest level of care for our patients.

In This Section

Diagnosing MS

No single test can diagnose MS. A full examination of the patients medical history, neurologic exam and lab tests help physicians rule out other diseases and confirm the MS diagnosis.

MS Treatment

Every patient has a unique treatment plan that can range from medications, infusion treatment, and rehabilitation therapies that help manage symptoms. 

MS Treatment Team

The Penn MS team works closely with experts across multiple disciplines to provide diagnosis, care and a treatment plan to help manage MS.

Patient Stories

Hear stories from multiple sclerosis patients who have been treated at the Penn MS Center. 

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