Division of Translational Medicine and Human Genetics

The Genome Editing lab, led by Dr. Tobias Raabe, is focused on:

1. The functional study of cardiovascular and liver disease associated gene mutations

2. The development of regenerative medicine and gene therapy

3. Establishing a robust method for the genetic manipulation of adult ductal liver stem cells

Our research is interested in isolating and characterizing adult ductal liver stem cells. We use special culture conditions that allow derivation of these resident ductal stem cells from adult mouse and human liver without artificial immortalization. These conditions allow for their continuous 3D culture for more than one year with a 10 fold higher genetic stability  compared to iPSC cells. 

In addition, the Genome Editing Program has several collaborations on campus, including research into cardiovascular disease, Alzheimer’s disease, and schizophrenia. 

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