Cervical cancer diagnosis

How is cervical cancer diagnosed?

While there is no specific cervical cancer test, doctors typically use a Pap test to check the cervix for abnormal cells. If your Pap test shows abnormal results indicating the presence of precancerous cells or suspected cancer, your doctor may recommend additional testing to identify the specific abnormality. One such test is a colposcopy. During a colposcopy, the cervix and vagina are gently swabbed with diluted vinegar, or acetic acid, to remove the mucus that covers the surface areas and highlight abnormal tissues. Your doctor may capture images as a reference to show precancerous cells. A small sample of cervical tissue will be removed for a pathologist to examine under a microscope.

If the colposcopy is abnormal, meaning cancer is suspected, your doctor may suggest an additional procedure to biopsy or remove a piece of the cervix for further examination. Your doctor will gather this cervix sample using cryosurgery or cervical ablation, which uses liquid nitrogen to remove the abnormal cells, or a loop electrosurgical excision procedure (LEEP), which uses a small wire loop and a mild electric current to remove the abnormal tissue. Depending on the amount and location of suspected cancerous cells in your cervix, you may need to undergo several biopsies before your cervical cancer diagnosis is confirmed. Your doctor will discuss which biopsies are necessary for your situation.

If you are diagnosed with cervical cancer, your prognosis will depend on several factors, including:

  • Your age and overall health 
  • How much of the cervix is affected 
  • Whether the cancer has spread to other parts of the body 
  • Whether you have human papillomavirus (HPV) or human immunodeficiency virus (HIV) 
  • If the cancer is new or has come back 
  • The type and stage of the cancer

Cervical cancer stages

Staging is a system your doctor uses to record a cancer’s size, aggressiveness, and growth to determine the most effective therapy for each patient. More specifically, the process of staging helps doctors determine:

  • The size of the tumor
  • Whether the cancer has spread to nearby lymph nodes and tissues
  • Whether the cancer has spread to other parts of the body

To determine accurate staging, you may have to undergo a pelvic exam under anesthesia, cystoscopy (examination of the lining of the bladder with a camera), proctoscopy (examination of the inside of the rectum with a scope), or a radiologic scan (IVP-intravenous pyelogram, CT scan, or PET scan). Your doctor will talk with you about test results and let you know which stage your cancer aligns with. By understanding the stage of your cancer, you can make informed decisions about your treatment.

There are four stages of cervical cancer, from Stage I through Stage IV.

Diagnosing cervical cancer at Penn Medicine

We understand that an accurate and quick diagnosis of cervical cancer is key to offering the best cervical cancer treatment options in a timely manner. Our team uses the latest and most advanced cervical cancer screenings, diagnostic tools, tests, and techniques for diagnosis. We also actively research better and more precise ways to detect this and other types of gynecologic cancer. By using a precise method for staging cervical cancer, our specialists can create a treatment plan specifically for you.

Your doctor may use one or more of the following tests to confirm your cervical cancer diagnosis:

National Cancer Institute Designated Comprehensive Cancer Center badge on top of shot of hospital

Rated “exceptional” by The National Cancer Institute

Penn Medicine’s Abramson Cancer Center is a world leader in cancer research, patient care, and education. Our status as a national leader in cancer care is reflected in our continuous designation as a Comprehensive Cancer Center by the National Cancer Institute (NCI) since 1973, one of 7 such centers in the United States. The ACC is also a member of the National Comprehensive Cancer Network, one of a select few cancer centers in the U.S., that are working to promote equitable access to high-quality, advanced cancer care.

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