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Multiple Myeloma Diagnostic Tools and Tests

The following tests and diagnostic procedures may be used to diagnose multiple myeloma:

  • A physical exam and full medical history evaluation including urine test
  • A complete blood count (CBC) that will examine the number of red blood cells and platelets, and the number and type of white blood cells. The CBC will also examine other portions of the blood.
  • Blood chemistry studies
  • Myeloma-specific blood tests including serum protein electrophoresis (SPEP), quantitative immunoglobulin levels and serum light chain analysis
  • 24-hour urine sample for urine protein electrophoresis
  • Bone marrow biopsy with chromosomal testing
  • Cytogenetic analysis
  • Imaging studies such as PET scans, CT scans, x-rays and MRI