What is metastatic melanoma?

Melanoma that has metastasized or spread beyond draining lymph nodes is considered stage IV melanoma. The most common sites of spread beyond the skin include the lung, liver and brain.

Metastatic melanoma treatment

Our recommended treatment for patients with metastatic melanoma depend on multiple factors, including the patient’s age and overall health, the locations and number of metastases, how fast the disease is spreading, and the patient’s wishes for treatment.

Treatment options include:

Your cancer treatment should not be “one-size-fits-all.” Through the Melanoma Program, we work with you to create a plan that may include one or a combination of treatments.

National Cancer Institute "Designated Comprehensive Cancer Center" badge on top of exterior shot of the Perelman Center for Advanced Medicine

Rated “exceptional” by The National Cancer Institute

Penn Medicine’s Abramson Cancer Center is a world leader in cancer research, patient care, and education. Our status as a national leader in cancer care is reflected in our continuous designation as a Comprehensive Cancer Center by the National Cancer Institute (NCI) since 1973, one of 7 such centers in the United States. The ACC is also a member of the National Comprehensive Cancer Network, one of a select few cancer centers in the U.S., that are working to promote equitable access to high-quality, advanced cancer care.

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Patient stories

Jamil Rivers leads women of color to better breast cancer care

Jamil Rivers is a full-time working mom, living with metastatic breast cancer, and leading an initiative to help other women of color navigate cancer care.

A journey from battlefield to beating cancer

Andrew Camponelli was a young Army helicopter pilot in Kuwait when he was diagnosed with stage 3 melanoma.

In the face of skin cancer, proton made all the difference

A Lancaster man and father of two reveals how proton therapy helped him beat skin cancer and reclaim his life.

A grateful patient pays it forward to treat uterine cancers

Dalia Jakas credits her doctor with curing her uterine cancer without harming her quality of life. Now, she’s paying it forward for future patients.

Redefining the cancer bell to celebrate with meaning

The Abramson Cancer Center wants to make bell-ringing more inclusive, so cancer patients can recognize their moments to cheer, large and small.

CNN anchor Kasie Hunt had brain surgery at Penn

Before starting her own daily news show, journalist Kasie Hunt came to Penn Medicine for a growing brain tumor that was causing painful headaches.

Finding triple-negative breast cancer at 33, she chose ‘Team Penn’

Shocked to learn she had stage III breast cancer, Kate Korson knew just where to go. She flew home to Penn Medicine, where a clinical trial saved her life.

A community hospital is a destination for cancer care

At Lancaster General Health, receiving advanced treatments closer to home has changed the battle with cancer for patients across central Pennsylvania.

The road to recovery begins at home

Penn Medicine’s SNF at Home pilot program offers a seamless transition from the hospital to home with extra support to recover in familiar surroundings.

Patient puts national spotlight on cancer clinical trials

As Kate Korson recently shared on Good Morning America, both she and her mother participated in clinical trials at Abramson Cancer Center.

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