The type of myeloproliferative neoplasm is based on whether too many red blood cells, white blood cells, or platelets are being made.
- Chronic myelogenous leukemia (CML), occurs when immature cells that would be red blood cells, white blood cells, or platelets overtake the bone marrow and blood.
- Essential thrombocythemia, occurs when too many platelets are made in the bone marrow.
- Myelofibrosis (also called primary or chronic idiopathic myelofibrosis), occurs when abnormal blood cells and scarring build up within the bone marrow.
- Polycythemia vera, occurs when too many red blood cells are formed in the bone marrow.
- Chronic myeloproliferative disorders sometimes can become acute leukemia, in which too many immature abnormal white blood cells are made. This is a rare event.
Other, less common, myeloproliferative disorders include:
- Chronic eosinophilic leukemia
- Chronic neutrophilic leukemia
- Myeloproliferative/myelodysplastic syndromes
- Neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB OR FGFR1 genes
Statistics for Myeloproliferative Neoplasms
The incidence for each type of MPN varies.
- Chronic myelogenous leukemia affects approximately 1.75 people per 100,000 per year.
- Essential thrombocythemia affects 2.3 people per 100,000 per year.*
- Myelofibrosis affects up to 1 person per 100,000 per year.*
- Polycythemia vera affects up to 2.6 people per 100,000 per year.*
Reference: Anderson and McMullan, Curr Hematol Malig Rep. 2014 Aug 17. [Epub ahead of print] Epidemiology of MPN: What Do We Know?
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