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Types of Myeloproliferative Neoplasms

The type of myeloproliferative neoplasm is based on whether too many red blood cells, white blood cells, or platelets are being made.

  • Chronic myelogenous leukemia (CML), in which immature cells that would be red blood cells, white blood cells, or platelets overtake the bone marrow and blood.
  • Essential thrombocythemia, in which too many platelets are made in the bone marrow
  • Myelofibrosis (also called primary or chronic idiopathic myelofibrosis), in which abnormal blood cells and scarring build up within the bone marrow
  • Polycythemia vera, in which too many red blood cells are formed in the bone marrow

Chronic myeloproliferative disorders sometimes can become acute leukemia, in which too many immature abnormal white blood cells are made. This is a rare event.

Other, less common, myeloproliferative disorders include:

  • Chronic eosinophilic leukemia.
  • Chronic neutrophilic leukemia.
  • Mastocytosis
  • Myeloproliferative/myelodysplastic syndromes
  • Neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB OR FGFR1 genes

Personalized Diagnostics at Penn Medicine

Penn Medicine’s Center for Personalized Diagnostics (CPD) is paving the way for a new era of genomic medicine.

The CPD offers the highest volume of genome testing in the region, with a large volume of clinical and research samples to date. In clinical cases, disease-associated mutations have been reported in 75% of patient tests revealing results with prognostic and therapeutic significance.

Learn more about Penn Medicine’s Center for Personalized Diagnostics.