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Chronic Myeloid Leukemia (CML) Diagnostic Tools

Many people do not have symptoms of chronic myeloid leukemia (CML) when they are diagnosed.

They may be diagnosed during a routine check up, or if their family doctor prescribes blood tests for an unrelated issue.

If a physician suspects CML, the following tests and diagnostic procedures may be used to further diagnose CML and its phase:

  • A physical exam and full medical history evaluation
  • A complete blood count (CBC) that will examine the number of red blood cells and platelets, and the number and type of white blood cells
  • Blood chemistry studies
  • A bone marrow aspiration and biopsy, which will remove some bone marrow, blood, and a small piece of the bone through the hip or breastbone. The tissue is then examined for abnormal cells.
  • Genetic analysis and sequencing through Penn Medicine's Center for Personalized Medicine that will identify genomic alterations, including the Philadelphia chromosome, so clinicians can design and implement optimal treatment plans.

Penn's Hematology and Hematopathology labs provide routine hematologic tests that diagnose and classify CML phases.