Plummer-Vinson syndrome

The cause of Plummer-Vinson syndrome is unknown. Genetic factors and a lack of certain nutrients (in particular iron deficiency anemia) may play a role. It is a rare disorder that can be linked to cancers of the esophagus and throat. It is more common in women.

Plummer-Vinson syndrome is a condition that can occur in people with long-term (chronic) iron deficiency anemia. People with this condition have problems swallowing due to small, thin growths of tissue (webs) that partially block the upper food pipe (esophagus).

Your health care provider will do an exam to look for abnormal areas on your skin and nails.

You may have an upper GI series or upper endoscopy to look for abnormal tissue in the food pipe. You may have tests to look for anemia or iron deficiency.

People with this condition generally respond to treatment.

Devices used to stretch the esophagus (dilators) may cause a tear. This can lead to bleeding.

Plummer-Vinson syndrome has been linked to esophageal cancer.

Getting enough iron in your diet may prevent this disorder.

Bass AJ, Rustgi AK. Neoplasms of the esophagus and stomach. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 178.

Falk GW, Katzka DA. Diseases of the esophagus. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 124.

Hammad H, Wani S. Esophageal tumors. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 48.

Symptoms may include:

• Difficulty swallowing
• Weakness or fatigue from the anemia

Taking iron supplements may improve the swallowing problems. Sometimes, intravenous (IV) iron is needed.

If supplements do not help, the web of tissue can be widened during upper endoscopy. This will allow you to swallow food normally.

Contact your provider if:

• Food gets stuck after you swallow it
• You have severe fatigue and weakness