Food allergy

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Causes

Many people have a food intolerance. This term usually refers to heartburn, cramps, belly pain, or diarrhea that can occur after they eat foods such as:

A true food allergy is much less common.

The immune system normally protects the body against harmful substances, such as bacteria and viruses. It also reacts to foreign substances called allergens. These are usually harmless, and in most people, do not cause a problem.

In a person with a food allergy, the immune response is oversensitive. When it recognizes an allergen, the immune system launches a response. Chemicals such as histamines are released. These chemicals cause allergy symptoms.

Any food can cause an allergic reaction. The most common food allergies are to:

  • Eggs (mostly in children)
  • Fish (older children and adults)
  • Milk (people of all ages)
  • Peanuts (people of all ages)
  • Shellfish such as shrimp, crab, and lobster (people of all ages)
  • Soy (mostly in children)
  • Tree nuts (people of all ages)
  • Wheat (people of all ages)

In rare cases, food additives, such as dyes, thickeners, or preservatives can cause a food allergy or intolerance reaction.

Some people have an oral allergy. This is an allergy type syndrome that affects the mouth and tongue after they eat certain fresh fruits and vegetables:

  • Melons, apples, peaches, pineapple, and other foods contain proteins that are similar to certain pollen proteins.
  • The reaction most often occurs when you eat the raw form of the foods. How severe the reaction is depends on how much of the food you eat. If the food is cooked, there is no reaction.
  • Unlike true food allergies, people with the oral allergy syndrome rarely develop severe allergic reactions such as anaphylaxis.

Definition

A food allergy is a type of immune response triggered by eggs, peanuts, milk, shellfish or some other specific food.

What are common symptoms of food allergies?The correct answer is all of the above. Eating something you're allergic to can trigger symptoms ranging from a runny nose to a dangerous full-body reaction. Talk to your doctor if you have any of these symptoms after eating a food, even if it's a small reaction.Food allergy and food intolerance are the same.The correct answer is false. A food allergy occurs when your immune system overreacts to a food and releases the chemical histamine. This causes allergic symptoms. Food intolerance is more common and doesn't involve your immune system. Sometimes it occurs because you can't digest part of a food, such as lactose, a type of sugar in milk. Which is a common food allergy?The correct answer is all of the above. Any food can cause an allergic reaction, but these are the most common. Other common foods include shellfish, soy, and tree nuts.If you eat something you're allergic to, your body will react within:The correct answer is two hours. Rarely, the symptoms may begin several hours after eating the food. Mild symptoms, such as a hive on your chin after eating something, will disappear soon and do not require treatment. However, you should tell your doctor about it. For some people, food allergies can be life-threatening.The correct answer is true. Some people have a severe allergic reaction, called anaphylaxis. This causes a whole-body reaction. Symptoms can start within minutes and may include breathing and swallowing problems, slurred speech, or passing out. If you have any of these symptoms, call 911 right away.The only proven treatment for a food allergy is to avoid the food.The correct answer is true. If you're allergic to a food, the best way to prevent a reaction is to cut the food from your diet. Other treatments, such as allergy shots and probiotics, don't work to treat food allergies.Many children outgrow their allergy to:The correct answer is eggs. Many children will outgrow their allergy to eggs, milk, wheat, and soy by the time they are 5 years old if they avoid that food when they are young. Allergies to peanuts, tree nuts, and shellfish tend to last a lifetime. To find out if you're still allergic to a food, you should eat a small amount.The correct answer is false. Do not eat a food that caused a reaction in the past without checking with your doctor first. A mild reaction in the past can become a more severe reaction the second or third time you try a food. Your doctor may want to be present when you try the food.People with food allergies should always carry epinephrine.The correct answer is true. Epinephrine is a medicine you can carry with you. It can stop a severe allergic reaction and save your life. It comes in a small syringe that is ready for you to give yourself a shot. If you've had an allergic reaction to food -- even a mild reaction -- talk to your doctor about this medicine.If you begin wheezing after eating a food, you should:The correct answer is to inject epinephrine and then call 911. Make sure you know how to use it. Also show loved ones how to use it in case you can't inject yourself.Fresh fruits are a common cause of mouth allergies.The correct answer is true. If you have an allergy to fruits such as melons, apples, pineapple, and other fruits, it can cause your lips, tongue and throat to itch – especially if you eat them raw. The more fruit you eat, the more severe the reaction. A more severe reaction is rare.Which of the following may prevent food allergies in children?The correct answer is breastfeeding. Waiting to add allergy-causing foods until your baby is a little older also may help. The timing for this varies from food to food and from baby to baby. Ask your child’s health care provider when is best to start certain foods that commonly cause allergic reactions.

Exams and Tests

Blood or skin tests are sometimes used to confirm that you have an allergy. A double-blind food challenge is one way to diagnose true food allergies. During this test, you and your health care provider will not know what you are eating. This is not commonly done.

With elimination diets, you avoid the suspected food until your symptoms disappear. Then you start eating the foods again to see if you develop a reaction. This is only done for food sensitivities or mild reactions. If a food has caused severe symptoms in the past, this should not be attempted.

In provocation (challenge) testing, you eat a small amount of the suspected food under medical supervision. This type of test may cause severe allergic reactions. Challenge testing should only be done by a trained provider. Typically, this test is done when there is a question about whether there is a food allergy or not.

Never try to cause a reaction or reintroduce a food on your own. These tests should only be done under the guidance of a provider, especially if your first reaction was severe.

Outlook (Prognosis)

Allergies to peanuts, tree nuts, and shellfish tend to last a lifetime.

Avoiding the problem foods may be easy if the food is uncommon or easy to identify. When eating away from home, ask detailed questions about the food you are served. When buying food, read package ingredients carefully.

Possible Complications

Anaphylaxis is a severe, whole-body allergic reaction that is life threatening. People at risk for anaphylaxis should carry epinephrine with them at all times.

Although people with oral allergy syndrome may have an anaphylactic reaction in rare cases, they should ask their provider if they need to carry epinephrine.

Food allergies can trigger or worsen asthma, eczema, or other disorders.

Prevention

There is no known way to prevent food allergies.

Avoiding peanuts in early childhood does not appear to prevent, and may even enhance, the development of peanut allergy. Providers now suggest introducing peanut-containing foods to infants, which may prevent peanut allergy. There is also evidence that introducing eggs by 12 months of age can prevent egg allergy.

Once an allergy has developed, carefully avoiding the offending food usually prevents further problems.

References

Bird JA, Burks AW. Food allergy. In: Rich RR, Fleisher TA, Schroeder HW, Weyand CM, Corry DB, Puck JM, eds. Clinical Immunology. 6th ed. Philadelphia, PA: Elsevier; 2023:chap 49.

Sicherer SH, Lack G, Jones SM. Food allergy management. In: Burks AW, Holgate ST, O'Hehir RE, et al, eds. Middleton's Allergy: Principles and Practice. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 82.

Togias A, Cooper SF, Acebal ML, et al. Addendum guidelines for the prevention of peanut allergy in the United States: report of the National Institute of Allergy and Infectious Diseases-sponsored expert panel. J Allergy Clin Immunol. 2017;139(1):29-44. PMID: 28065278 pubmed.ncbi.nlm.nih.gov/28065278/.

Support Groups

The following groups can provide more information about food allergies:

Symptoms

Symptoms usually begin within 2 hours after eating. Sometimes, the symptoms begin a longer time after eating the food.

Key symptoms of a food allergy include hives, a hoarse voice, and wheezing.

Other symptoms that may occur include:

  • Swelling (angioedema), especially of the eyelids, face, lips, and tongue
  • Trouble swallowing or breathing due to swelling in the throat
  • Itching of the mouth, throat, eyes, skin, or any other area
  • Dizziness, lightheadedness, fainting, or feelings of impending doom
  • Nasal congestion, runny nose
  • Stomach cramps, diarrhea, nausea, or vomiting

Symptoms of mouth (oral) allergy syndrome:

  • Itchy lips, tongue, and throat
  • Swollen lips (sometimes)

Severe allergic reactions can happen immediately or within two hours after eating. This is called anaphylaxis and can be life threatening. In addition to the above symptoms, you may have low blood pressure and shortness of breath due to narrowed airways.

Treatment

If you suspect that you or your child has a food allergy, see an allergy specialist (allergist).

Treatment may involve any of the following:

  • Avoiding the food (this is the most effective treatment).
  • Desensitization, during which you eat a small amount of the food each day. This must be done under an allergist's guidance.
  • Omalizumab (Xolair), an injection every 2 or 4 weeks to decrease sensitivity to food allergies.

Other treatments, including allergy shots and probiotics, have not been proven to help with food allergies. However, some people find that their oral allergy symptoms improve after taking allergy shots.

If your child has a problem with cow's milk formula, your provider may suggest trying a soy-based formula or something called an elemental formula, if it is available.

If you have symptoms on only one area of your body, for example, a hive on your chin after eating the food, you may not need any treatment. The symptoms will likely go away in a brief time. Antihistamines may relieve the discomfort. Soothing skin creams may also provide some relief.

If you develop any type of serious or whole-body reaction (even hives) after eating a food, you should learn how to use injectable or intranasal epinephrine. You should have two epinephrine devices with you at all times.

  • Use the epinephrine.
  • Then go to the nearest hospital or emergency facility right away, preferably by ambulance.
  • If you develop severe allergy symptoms or anaphylaxis, call 911 or the local emergency number.

When to Contact a Medical Professional

Steps to take when a food allergy reaction occurs:

  • Call 911 or the local emergency number if you have any serious or whole-body reactions, particularly wheezing or difficulty breathing, after eating any food.
  • If your provider prescribed epinephrine for severe reactions, use it as soon as possible, even before calling 911. The sooner you use the epinephrine, the better.
  • Anyone who has had an allergic reaction to a food, should be seen by an allergist.

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