What is the INVOcell® procedure?

INVOcell®, sometimes called a vaginal incubator, is a Food and Drug Administration (FDA)-cleared fertility treatment that uses a person’s vagina to develop an embryo. Unlike in vitro fertilization (IVF), where incubation occurs in a laboratory, INVOcell uses intravaginal culture (IVC) to grow an embryo.

Our fertility and reproductive care specialists place your eggs, sperm from your partner or donor, and culture fluid in a small capsule-like device about the size of a walnut. Then, your doctor inserts the device into your vagina. It stays there for several days while the embryos form. We remove developed embryos from the device and place one or more of them in your uterus so they can continue to grow.

Simpler and less expensive than IVF, the INVOcell procedure is a popular alternative to traditional IVF. 

Who is a candidate for INVOcell?

Reproductive endocrinology at Penn Medicine often recommends INVOcell as an alternative to IUI or IVF. Many individuals and couples choose INVOcell for its benefits, such as cost savings or feelings of increased connection to the fertilization process.

Ideal candidates for INVOcell are individuals under age 38 with:

  • Body mass index (BMI) less than 35
  • Good quality eggs
  • Ovulation problems or unexplained fertility

What to expect during INVOcell

You and your fertility doctor will decide if INVOcell is right for you. INVOcell procedure steps include:

Recovery from the INVOcell procedure

There’s no recovery time associated with the INVOcell procedure. While INVOcell is in your vagina, you should avoid:

  • Hot baths or saunas
  • Inserting anything into your vagina
  • Intercourse
  • Strenuous activity
  • Swimming

Two weeks after the embryo transfer, you may take a pregnancy test. Your doctor may ask you to return to the clinic for a blood test to confirm the pregnancy.

How successful is INVOcell?

Success rates of INVOcell are similar to IVF and higher than intrauterine insemination (IUI). Penn Medicine fertility experts help you decide which treatment is right for you based on your healthy history and personal risk factors.

What does INVOcell cost?

The cost of the INVOcell treatment varies depending on your specific needs, which you’ll discuss with your doctor. Typically, INVOcell costs about 50 percent less than traditional IVF. The procedure has reduced lab expenses since incubation happens inside a person’s vagina instead of in a laboratory.

We know the cost of fertility treatments like INVOcell can be daunting since many health plans don’t cover these procedures. A Penn Medicine financial advocate can help you explore options and discover resources to help you pay for fertility care.

Pioneers of INVOcell at Penn Medicine

Penn Medicine was one of the first fertility practices in the region to offer this innovative, FDA-cleared fertility treatment. Since introducing INVOcell in 2018, we’ve helped many individuals and couples start and grow their families with the procedure.

Our fertility care providers have expertise in the INVOcell procedure and other fertility treatments. They help you navigate your options and choose which offers you the highest chance of becoming pregnant.

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