Neurogastroenterology and GI motility

Neurogastroenterology studies the relationship between the nervous and digestive systems, sometimes called “the brain-gut axis.” Disruptions in this relationship can affect how food travels through the GI tract and can speed up or slow down digestion, often causing symptoms that disrupt daily life. Conditions related to neurogastroenterology and GI motility (movement), such as chronic reflux, difficulty swallowing, chronic nausea, and constipation are among the most common reasons people seek digestive care.

At Penn Medicine, we are one of the most experienced centers in the region caring for people with intestinal motility disorders, gastric motility problems, and other complex issues involving the esophagus (the tube that conveys food and liquid), stomach, and intestines. Whether symptoms are mild or advanced, our GI motility specialists deliver thoughtful, personalized care backed by leading diagnostic tools and in collaboration with dietitians, physical therapists, and others. Our care is strengthened by ongoing research on the frontiers of nutrition and the microbiome. We also support educational programs and fellowships that train future experts in digestive health.

Treatment may include lifestyle changes, targeted medications, nutrition support, and therapies to strengthen or retrain digestive muscles. Many motility disorders come with complex symptoms, and your recommended treatment options will depend on your specific diagnosis and goals. If you live outside of the region, we may be able to work in coordination with your local physician to treat your motility disorder without requiring regular travel to Philadelphia.

If your condition and symptoms cannot be effectively managed with other treatment options. Penn Medicine is home to experts in gastrointestinal surgery who perform minimally invasive procedures whenever possible.