Urethral cancer risks and prevention

Understanding urethral cancer risks and prevention

Urethral cancer is a rare type of cancer that starts in the urethra, the tube that carries urine from the bladder. It can affect any part of the urethra and may spread to nearby tissues or other parts of the body if not treated. Some factors can increase the risk of developing urethral cancer, such as certain conditions or behaviors. Recognizing and understanding these risk factors can be important for managing and reducing your risk of the disease.

Urethral cancer risk factors

Although the exact cause of urethral cancer remains unclear, several factors may increase the risk, including those who:

  • Are age 60 or older
  • Were assigned male at birth
  • Are Black or African descent
  • Experience frequent urinary tract infections or sexually transmitted infections
  • Have a history of bladder cancer 
  • Have a history of diseases in the urethra
  • Have a history of human papillomavirus (HPV)

It’s important to remember that having one or more risk factors doesn’t mean you’ll develop urethral cancer. However, consulting with your Penn Medicine care team can help you assess your risk.

Is urethral cancer hereditary?

Urethral cancer isn’t commonly known to be hereditary. While most cases of urethral cancer develop without a clear genetic link, having a family history of certain types of cancer, such as bladder cancer or prostate cancer, may slightly increase the risk. However, the overall genetic predisposition for urethral cancer is not well-established compared to other cancers with stronger hereditary links.

If you have concerns about your family history and cancer risk, discuss them with your provider or a genetic counselor who can provide advice and potential screening options.

Can urethral cancer be prevented?

Although complete prevention of urethral cancer may not be possible, you can take proactive steps to lower your risk and enhance your overall health.

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Rated “exceptional” by The National Cancer Institute

Penn Medicine’s Abramson Cancer Center is a world leader in cancer research, patient care, and education. Our status as a national leader in cancer care is reflected in our continuous designation as a Comprehensive Cancer Center by the National Cancer Institute (NCI) since 1973, one of 7 such centers in the United States. The ACC is also a member of the National Comprehensive Cancer Network, one of a select few cancer centers in the U.S., that are working to promote equitable access to high-quality, advanced cancer care.

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