What is neuralgia?

Neuralgia is a sharp, severe, and often burning pain that follows a nerve pathway and results from nerve irritation or damage. It can occur anywhere in the body and is usually a symptom of an underlying condition.  

What are the types of neuralgia?

There are several types of neuralgia, each with its own characteristics: 

  • Trigeminal neuralgia is the most common type of neuralgia, causing sudden jolts of shooting pain primarily on one side of the face. Everyday activities like toothbrushing can trigger severe pain. This type of neuralgia is often linked to causes like multiple sclerosis or nerve compression. 
  • Occipital neuralgia involves irritation of the nerve at the back of the skull that results in dull, throbbing pain, usually in the back of the head. Tense muscles, ligaments, or infections may be contributing factors. 
  • Postherpetic neuralgia is associated with the reactivation of the varicella-zoster virus (chickenpox and shingles). This type of neuralgia causes pain and nerve damage after a shingles infection. The pain often persists even after the infection subsides. 
  • Peripheral neuralgia (peripheral neuropathy) results from nerve damage in the peripheral nervous system, affecting areas like the hands, feet, arms, and legs. It can lead to pain, numbness, muscle twitching, coordination difficulties, and other symptoms. 
  • Intercostal neuralgia is caused by factors like chest injuries, nerve pressure, or viral infections that affect the nerves beneath the ribs, causing sharp, burning chest and upper abdominal pain. Movements like breathing, coughing, or laughing may worsen the pain. 

Symptoms of neuralgia

Neuralgia typically manifests with specific symptoms, including: 

  • Increased sensitivity of the skin along the affected nerve’s path, making touch or pressure painful  
  • Localized pain that may be extremely sensitive to touch 
  • Muscle weakness or spasms 
  • Sharp or stabbing pain along the pathway of a damaged nerve, which may be intermittent or constant and burning 
  • Tingling, numbness, or involuntary muscle twitching 

The exact location and nature of the symptoms may vary depending on the specific type of neuralgia you have. 

What causes neuralgia?

Neuralgia pain arises due to disruptions in a nerve’s structure or function due to nerve damage, compression, or changes in nerve function. Neuralgia can be caused by various factors including: 

  • Blood disorders like porphyria  
  • Chronic kidney disease 
  • Diabetes 
  • Infections like herpes zoster (shingles), HIV/AIDS, Lyme disease, and syphilis 
  • Medications 
  • Pressure on nerves from nearby structures such as bones, ligaments, blood vessels, or tumors 
  • Trauma or surgery 

In many cases, the cause of neuralgia remains unknown. 

Neuralgia treatment and management

Treatment options for neuralgia may vary depending on the underlying cause, the location of the pain, and its severity. You may be prescribed medications, including antidepressants, anti-seizure drugs, and over-the-counter or prescription pain medications.

Penn Medicine offers comprehensive diagnosis and advanced treatment options for a wide range of brain, spine, and peripheral nerve conditions, including neuralgia. Our experts provide accurate diagnoses and personalized treatments to alleviate painful symptoms and enhance your overall quality of life.

Some additional treatments for neuralgia include:

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