Cerebral amyloid angiopathy

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What is cerebral amyloid angiopathy?

Cerebral amyloid angiopathy, also known as CAA, is a build-up of amyloid proteins in the brain’s arterial walls. It’s relatively common among patients aged 65 and older, and in patients with Alzheimer’s disease and other forms of dementia.  

Over time, the build-up of amyloids in the brain causes its blood vessels to weaken, which can lead to health issues like stroke or cerebral hemorrhage. It can take years or even decades for symptoms to develop. This condition can sometimes be hereditary, but it usually occurs on its own.  

While there is no cure for CAA, you can get expert and compassionate treatment for your symptoms. At Penn Medicine, our neurology specialists are dedicated to diagnosing and treating complex brain disorders like cerebral amyloid angiopathy. We also work with researchers in the development of clinical trials to offer innovative treatments to help relieve and manage your symptoms.  

Symptoms of cerebral amyloid angiopathy

Cerebral amyloid angiopathy symptoms will vary based on how far the disease has progressed, your age, any pre-existing health issues, and other factors. Symptoms also depend on whether there is bleeding in the brain. Your care team can help you reduce and relieve these symptoms as they arise. 

What causes CAA?

Although it’s linked to the aging process, there is no known cause of cerebral amyloid angiopathy. Certain types are linked to genetics and others occur sporadically. In the case of inherited CAA, the condition is often linked to changes in the amyloid protein precursor (APP) gene. These mutations are also associated with the development of Alzheimer’s disease.

While there is currently no proven way to prevent CAA, your doctor and care team may help you reduce the likelihood of associated health risks, like stroke, cognitive decline, and memory loss as they emerge. As soon as you notice symptoms, you can start working with Penn Medicine’s neurology experts to create a care plan that is right for you. 

Diagnosing cerebral amyloid angiopathy

Knowing that the likelihood of CAA increases with age, you and your doctor can work together to understand the signs and manage related health issues when they occur. If you’re experiencing serious symptoms, your doctor may conduct a physical exam and order imaging tests. By clearly communicating with your doctor about your symptoms, you can help them know when and how to check for CAA.  

CT scan
A CT scan helps diagnose traumatic injuries, cancer, vascular diseases, and many other conditions.
MRI
An MRI provides high-resolution images of the brain, spine, and many other structures in the body.
PET scan
A PET scan helps us diagnose diseases and plan treatment as early as possible.
MRA
A magnetic resonance angiogram (MRA) detects blood vessel problems quickly and accurately.

Cerebral amyloid angiopathy treatment and management

There is no treatment for CAA, and it can be difficult to confirm that you have the condition. You may experience symptoms well before you’ve received a CAA diagnosis. Our care team can help treat and manage any associated health complications and keep you informed about any clinical trials for treating this condition. We will work with you every step of the way to help you manage your CAA diagnosis using the latest and most advanced treatments to maximize your comfort and quality of life.

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Find a doctorCall 800-789-7366