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Zissimos Mourelatos, MD

Zissimos Mourelatos, MD Physician

Director, Neuropathology Professor of Pathology and Laboratory Medicine

Dr. Mourelatos is employed by Penn Medicine.

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About Dr. Zissimos Mourelatos

My areas of clinical expertise:


Surgical Neuropathology (Brain tumors; Brain biopsies; Muscle biopsies; Nerve biopsies)

Medical Neuropathology

Received the Penn Medicine Award of Excellence, 2006

Clinical Specialties


  • Pathology and Laboratory Medicine

Programs & Centers:

Board Certification:

  • Pathology - Anatomic and Clinical Pathology, 1999

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Aristotelian University of Thessaloniki
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania


Ad Hoc Member, Grant Reviews, Netherlands Organization for Health Research and Development, The Netherlands, International Ad Hoc Member, Grant reviews, Wellcome Trust, London, UK, International Ad Hoc Member, NCF Study Section CSR/NIH, National Ad Hoc Member, ZCA1 GRB-S P01 Study Section, NCI/NIH, National Ad Hoc Member, ZMH1 ERB-L Study Section, CSR/NIH/NIMH, National American Association for the Advancement in Science, National American Association of Neuropathologists, National Chairperson, MGB Study Section CSR/NIH, National Human Frontier Science Program (HFSP), International Member, Grant Reviews, European Union Commission on Framework Grants; Brussels, EU, International Reviewer, Agence Nationale de la Recerche, France (ANR), International Reviewer, Austrian Science Fund, Vienna, Austria, International Reviewer, Hellenic Ministry of Education Research Council, Athens, Greece, International Reviewer, Israel Science Foundation, International Reviewer, Swedish Research Council, International

Hospital Affiliation

Dr. Mourelatos is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Biochemical and genetic studies of Ribonucleoproteins (RNPs) with emphasis on
small regulatory RNPs such as microRNAs (miRNAs) and piRNAs (Piwi-associated RNAs).
Biochemical and genetic studies of mRNA translation and mRNA decay.
Biochemical and genetic studies of RNA dysregulation in the pathogenesis of neurodegeneration.

Selected Publications:

Couthouis J, Hart MP, Erion R, King OD, Diaz Z, Nakaya T, Ibrahim F, Kim HJ, Mojsilovic-Petrovic J, Panossian S, Kim CE, Frackelton EC, Solski JA, Williams KL, Clay-Falcone D, Elman L, McCluskey L, Greene R, Hakonarson H, Kalb RG, Lee V-MY, Trojanowski JQ, Nicholson GA, Blair IP, Bonini NM, Van Deerlin VM, Mourelatos Z, Shorter J, Gitler AD: Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis Hum Molec Genet 21 (13): 2899-911,2012.

Liu X, Jin D-Y, McManus MT, Mourelatos Z: Precursor microRNA-programmed silencing complex assembly pathways in mammals Mol Cell 46 (4): 507-17,2012.

Vourekas A, Zheng Q, Alexiou P, Maragkakis M, Kirino Y, Gregory BD, Mourelatos Z: Mili and Miwi target RNA repertoire reveals piRNA biogenesis and function of Miwi in spermiogenesis Nat Struct Mol Biol 19 (8): 773-81,2012.

Venneti S, Moss HE, Levin MH, Vagefi MR, Brozena CS, Pruitt AA, Mourelatos Z, Trojanowski JQ, Galetta SL, Balcer LJ: Asymmetric bilateral demyelinating optic neuropathy from tacrolimus toxicity J Neurol Sci 301 (1-2): 112-5,2011.

Couthouis J, Hart MP, Shorter J, DeJesus-Hernandez M, Erion R, Oristano R, Liu AX, Ramos D, Jethava N, Hosangadi D, Epstein J, Chiang A, Diaz Z, Nakaya T, Ibrahim F, Kim HJ, Solski JA, Williams KL, Mojsilovic-Petrovic J, Ingre C, Boylan K, Graff-Radford NR, Dickson DW, Clay-Falcone D, Elman L, McCluskey L, Greene R, Kalb RG, Lee VM, Trojanowski JQ, Ludolph A, Robberecht W, Andersen PM, Nicholson GA, Blair IP, King OD, Bonini NM, Van Deerlin V, Rademakers R, Mourelatos Z, Gitler AD: A yeast functional screen predicts new candidate ALS disease genes Proc Natl Acad Sci USA 108 (52): 20881-90,2011.

Venneti S, Boateng LA, Friedman JR, Baldwin DA, Tobias JW, Judkins AR, Mourelatos Z, Priti L: MiRNA-9 and MiRNA-200a distinguish hemangioblastomas from metastatic clear cell renal cell carcinomas in the CNS Brain Pathol 22 (4): 522-9,2012.

Kirino Y, Vourekas A, Khandros E, Mourelatos Z: Immunoprecipitation of piRNPs and directional, next generation sequencing of piRNAs Methods Mol Biol 725 : 281-93,2011.

de Planell-Saguer M, Rodicio MC, Mourelatos Z: Rapid in situ codetection of noncoding RNAs and proteins in cells and formalin-fixed paraffin-embedded tissue sections without protease treatment Nat Protoc 5 (6): 1061-73,2010.

Kirino Y, Vourekas A, Kim N, de Lima Alves F, Rappsilber J, Klein PS, Jongens TA, Mourelatos Z: Arginine methylation of vasa protein is conserved across phyla J Biol Chem 285 (11): 8148-54,2010.

Kirino A, Vourekas A, Sayed N, de Lima Alves F, Thomson T, Lasko P, Rappsilber J, Jongens TA, Mourelatos Z: Arginine methylation of Aubergine mediates Tudor binding and germ plasm localization RNA 16 (1): 70-8,2010.

View all publications

Academic Contact Info

Department of Pathology and Laboratory Medicine
Division of Neuropathology
613B Stellar Chance Labs
422 Curie Boulevard

Philadelphia, PA 19104-6100
Phone: (215) 746-0014
Patient appointments: 800-789-7366 (PENN)

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