Description of Research Expertise

My research interest is focused on the study of brain metabolites in vivo in humans (in disease states such as Epilepsy, Schizophrenia, and in acute drug studies) and in preclinical models by MR spectroscopy and CEST MRI. I have been the lead MR scientist for several preclinical and clinical research projects involving the spectroscopic and CEST acquisitions and more recently towards the development of down-field MR spectroscopy. I would like to extend the experience I have gained over the years to study metabolism and capture the early detection and therapeutic monitoring of neurodegenerative diseases/neurological disorders.

Selected Publications

Ravi Prakash Reddy Nanga*, Mark A Elliott, Anshuman Swain, Neil E Wilson, Sophia Swago, Walter R Witschey, Ravinder Reddy (* Corresponding author): Identification of new resonances in downfield 1H MRS of human calf muscle in vivo: Potentially metabolite precursors for skeletal muscle NAD+ Magnetic Resonance in Medicine 90 (3): 1166-1171,2023.

Ravi Prakash Reddy Nanga*, Mark A. Elliott, Anshuman Swain, Neil Wilson, Sophia Swago, Narayan Datt Soni, Walter R. Witschey, Ravinder Reddy, (*Corresponding author): Identification of L-Tryptophan by down-field 1H MRS: A precursor for brain NAD+ and Serotonin syntheses Magnetic Resoannce in Medicine 88 (6): 2371-2377,2022.

Narayan Data Soni, Anshuman Swain, Paul Jacobs, Halvor Juul, Ryan Armbruster, Ravi Prakash Reddy Nanga, Kavindra Nath, Corinne Wiers, John Detre, Ravinder Reddy: In vivo assessment of β-hydroxybutyrate metabolism in mouse brain using deuterium (2H) magnetic resonance spectroscopy Magnetic Resonance in Medicine 90 (1): 259-269,2023.

Alfredo Lucas, Ravi Prakash Reddy Nanga, Peter Hadar, Stephanie Chen, Adam Gibson, Kelly Oechsel, Mark A. Elliott, Joel M. Stein, Sandhitsu Das, Ravinder Reddy, John A. Detre, Kathryn A. Davis: Mapping hippocampal glutamate in mesial temporal lobe epilepsy with glutamate weighted CEST (GluCEST) imaging Human Brain Mapping 44 (2): 549-558,2023.

Elizabeth Rosenfeld, Ravi Prakash Reddy Nanga, Alfredo Lucas, Andrew Y. Revell, Allison Thomas, Nina H. Thomas, David R. Roalf, Russel T. Shinohara, Ravinder Reddy, Kathryn A. Davis & Diva D. De León: Characterizing the neurological phenotype of the hyperinsulinism hyperammonemia syndrome Orphanet Journal of Rare Diseases 17 : 248,2022.

Andrew Neal, Brad Moffat, Joel M. Stein, Ravi Prakash Reddy Nanga, Patricia Desmond, Russell T. Shinohara, Hari Hariharan, Rebecca Glarin, Katharine Drummond, Andrew Morokoff, Patrick Kwan, Ravinder Reddy, Terence J. O'Brien, Kathryn A. Davis: Glutamate imaging in gliomas with 7 Tesla magnetic resonance imaging Neuroimage: Clinical 22 : 101694,2019.

Ravi Prakash Reddy Nanga*, Catherine DeBrosse, Dushyant Kumar, David Roalf, Brendan McGeehan, Kevin D’Aquilla, Arijitt Borthakur, Hari Hariharan, Damodara Reddy, Mark Elliott, John A. Detre, Cynthia Neill Epperson, Ravinder Reddy, (*Corresponding author): Reproducibility of 2D GluCEST in healthy human volunteers at 7.0T Magnetic Resonance in Medicine 80 (5): 2033-2039,2018.

David R. Roalf, Ravi Prakash Reddy Nanga, Petra E Rupert, Hari Hariharan, Megan Quarmley, Monica E. Calkins, Erich Dress, Karthik Prabhakaran, Mark A. Elliott, Paul J. Moberg, Ruben C. Gur, Raquel E. Gur, Ravinder Reddy and Robert I. Turetsky: Glutamate imaging (GluCEST) reveals lower brain GluCEST contrast in patients on the psychosis spectrum Molecular Psychiatry 22 (9): 1298-1305,2017.

Ravi Prakash Reddy Nanga*, Hari Hariharan, Ravinder Reddy, (*Corresponding author): Fully automated macromolecule suppressed single voxel glutamate spectroscopy (FAMOUS SVGS) Journal of Translational Medicine 14 (1): 220,2016.

Catherine DeBrosse*, Ravi Prakash Reddy Nanga*, Puneet Bagga, Kavindra Nath, Mohammed Haris, Francesco Marincola, Mitchell D Schnall, Hari Hariharan, Ravinder Reddy. (*Equal contribution): Lactate Chemical Exchange Saturation Transfer (LATEST) Imaging in vivo: A Biomarker for LDH Activity Scientific Reports 6 : 19517,2016.

Ravi Prakash Reddy Nanga, Catherine DeBrosse, Anup Singh, Kevin D'Aquilla, Hari Hariharan, Ravinder Reddy.: Glutaminase catalyzes reaction of glutamate to GABA Biochemical and Biophysical Research Communications 448 (4): 361-364,2014.

Crescenzi Rachelle, DeBrosse Catherine, Nanga Ravi Prakash Reddy, Reddy Sanjana, Haris Mohammed, Hariharan Hari, Iba Michiyo, Lee Virginia M Y, Detre John A, Borthakur Arijitt, Reddy Ravinder: In vivo measurement of glutamate loss is associated with synapse loss in a mouse model of tauopathy NeuroImage 101 : 185-92,2014.

Kathryn Adamiak Davis*, Ravi Prakash Reddy Nanga*, Sandhitsu Das, Stephanie H Chen, Peter N Hadar, John R Pollard, Timothy H Lucas, Russell T Shinohara, Brian Litt, Hari Hariharan, Mark A Elliott, John A Detre, Ravinder Reddy. (*Equal contribution): Glutamate imaging (GluCEST) lateralizes epileptic foci in nonlesional temporal lobe epilepsy Science Translational Medicine 7 (309): 309ra161,2015.

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Academic Contact Information

422 Curie Blvd
B1 Stellar-Chance Laboratories
Philadelphia, PA 19104