Marco Ruella, MD
Headshot of Marco Ruella, MD
Penn Medicine Provider

About me

  • Scientific Director of the Lymphoma Program
  • Associate Professor of Medicine (Hematology-Oncology)
  • Assistant Professor of Medicine in Pathology and Laboratory Medicine

Education and training

  • Medical School: Universita Degli Studi di Torino
  • Residency: University of Turin

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
Dr. Ruella is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Thomas C, Chung J, Landsburg D, Nasta SD, Svoboda J, Chong E, Schuster S, Carter J, Cook M, Tomasulo E, Elghway O, Lariviere M, Hubbeling H, Plastaras J, Villasenor-Park J, Myers C, Ruella M, Rook A, Kim E, Barta S. Clinical features and outcomes of patients with non-erythrodermic mycosis fungoides with high blood tumor burden. , In Proceedings of 67th American Society of Hematology Annual Meeting 2025: 2025


Knoedler L, Herfeld K, Schaefer DA, Diatta F, Clune J, Evans B, Seu M, Kim BS, Alfertshofer M, Schaschinger T, Iske J, Knoedler S, Lellouch AG, Jeljeli M, Carturan A, Ruella M, Heiland M, Poeck H, Perl M, Pomahac B, Kauke-Navarro M. CAR-T cell therapy and reconstructive oncologic surgery in peripheral solid tumors-A narrative review. , Cell Rep Med, 6(8): 2025


Bochi-Layec A, Cohen I, Lemoine J, Jenks S, Bayat P, Kim KH, Zhao H, Ugwuanyi O, Stella F, Ghilardi G, Gabrielli G, McCuaig S, Iatrou A, Vlachonikola E, Karypidou M, Bouziani E, Ramasubramanian R, Agathangelidis A, Paruzzo L, Bugrovsky R, Guruprasad P, Wang LP, Harris Jaryse, Zhang Y, Pajarillo R, Kreiger P, Fulmer B, Cases M, Porazzi P, Wherry JE, Apostolidis S, Bhoj V, Schuster SJ, Ghia P, Stamatopoulos K, Behrens E, Sanz I, Ruella M. Precision targeting of pathogenic B cells and autoantibodies in systemic lupus erythematosus using CAR T cells against the IGHV4-34 B cell receptor. , In Proceedings of 67th American Society of Hematology Annual Meeting 2025: 2025


Paruzzo L, Ho M, Han Noll J, Stella F, Cohen I, Ramirez-Fernandez A, Waxman A, Kapur S, Chen F, Huff A, Jarocha D, Koucky O, Hopkins C, Dimitri A, Lavorando M, Vogl D, Scholler J, Doto A, Everett J, Bushman F, Nathanson K, Porazzi P, Stadtmauer E, Susanibar-Adaniya S, Garfall A, Cohen A, Fraietta J, Ruella M. CCR5 blockade: A therapeutic approach to uncouple CART-BCMA expansion from CARTmediated immune toxicities. , In Proceedings of 67th American Society of Hematology Annual Meeting 2025: 2025


Paruzzo L, Bouvier R, Fulmer B, Cohen I, Chong E, Svoboda J, Nasta SD, Landsburg D, Patel V, Ho M, Carturan A, Stella F, Waxman A, Cohen A, Vogl D, Barta S, Bochi-Layec A, Porazzi P, Fraietta J, Garfall A, Bhoj V, Stadtmauer E, Porter D, Riley J, Merkel P, Schuster S, Carter J, Apostolidis S, Susanibar-Adaniya S, Ruella M. Chimeric antigen receptor T-cell therapy in patients with coexisting malignancy and autoimmune disease. , In Proceedings of 67th American Society of Hematology Annual Meeting 2025: 2025


Tan M, Giles J, Porazzi P, Torres L, Paruzzo L, Carturan A, KC W, Zhang Y, Pajarillo R, Wherry JE, Ruella M. SMARCA4 deletion enhances CAR T cell cytotoxicity and persistence against cancer. , In Proceedings of 67th American Society of Hematology Annual Meeting 2025: 2025


Lemoine J, Ghilardi G, Lee Y, Paruzzo L, Morena F, Perriello V, Li Z, Cohen I, Ugwuanyi O, Pajarillo R, Zhang Y, Guruprasad P, Patel R, Chong E, Nasta SD, Barta S, Garfall A, Landsburg D, Svoboda J, Sadigh S, Wasik M, Bhattacharyya, Porazzi P, Schsuter S, Falini B, Ruella M. Identification and functional characterization of a novel best-in-class anti-CD79b CAR T cell immunotherapy using a multidimensional screening strategy. , In Proceedings of 67th American Society of Hematology Annual Meeting 2025: 2025


Liu S, Guruprasad P, Ramasubramanian R, Madhu B, Paruzzo L, Han K, Shestov A, Zhou C, Lin J, Carturan A, Porazzi P, Chong E, Schuster S, Milone M, Thaiss C, Levy M, Ruella M. β‑hydroxybutyrate metabolism enhances CAR T cell function via transcriptional and epigenetic reprogramming. , In Proceedings of 67th American Society of Hematology Annual Meeting 2025: 2025


Tomasulo E, Chong E, Patel E, Rudolph J, Kim YA, Ruella M, Watts A, Hwang WT, Hughes M, Svoboda J, Landsburg, Chong E, Nasta SD, Barta S, Thomas C, Cook M, Carter J, Fradley M, Schuster S. Cardiovascular outcomes of patients transitioned from ibrutinib to an alternate bruton tyrosine kinase inhibitor for hypertension and/or cardiovascular adverse events. , In Proceedings of 67th American Society of Hematology Annual Meeting 2025: 2025


Paruzzo L, Mantione A, Chong E, Nasta SD, Landsburg D, Carter J, Cook M, Fardella E, Bigdeli A, Patel V, Imparato A, Thomas C, Souza V, Carturan A, Stella F, Pucillo M, Pooja D, Tomasulo E, Barta S, Schuster S, Halper-Stromberg E, Ruella M, Svoboda J. Large B-cell lymphoma following CD19-directed CART-cell therapy failure: Impact of CAR construct on disease features and outcomes of subsequent therapies. , In Proceedings of 67th American Society of Hematology Annual Meeting 2025: 2025


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