Marco Ruella, MD
Hematology
Sees patients age 18 and up
Abramson Cancer Center Perelman 4th Floor West
Penn Medicine Provider

About me

  • Scientific Director of the Lymphoma Program
  • Associate Professor of Medicine (Hematology-Oncology)
  • Assistant Professor of Medicine in Pathology and Laboratory Medicine

Education and training

  • Medical School: Torino Medical School
  • Fellowship: University of Torino Medical School

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
Dr. Ruella is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Knoedler L, Herfeld K, Schaefer DA, Diatta F, Clune J, Evans B, Seu M, Kim BS, Alfertshofer M, Schaschinger T, Iske J, Knoedler S, Lellouch AG, Jeljeli M, Carturan A, Ruella M, Heiland M, Poeck H, Perl M, Pomahac B, Kauke-Navarro M. CAR-T cell therapy and reconstructive oncologic surgery in peripheral solid tumors-A narrative review. , Cell Rep Med, 6(8): 2025


Shukla D, Manne S, Jiang S, Ruella M, Wherry EJ, Riley JL. Optimal pairing of binder and co-stimulatory domains improves dual CART cell efficacy. , Mol Ther.: 2025


Grzywa TM, Neeser A, Ramasubramanian R, Romanov A, Tannir R, Mehta NK, Cossette B, Morgan DM, Goncalves B, Sukaj I, Bergaggio E, Kadauke S, Myers RM, Paruzzo L, Ghilardi G, Cozzone A, Schuster SJ, Frey N, Zhang L, Yousefpour P, Abraham W, Suh H, Ruella M, Grupp SA, Chiarle R, Wittrup KD, Ma L, Irvine DJ. Directed evolution-based discovery of ligands for in vivo restimulation of chimeric antigen receptor T cells. , Nat Biomed Eng.: 2025


Guruprasad P, Ramasubramanian R, Nason S, Carturan A, Liu S, Paruzzo L, Hornet V, Plesset J, Patel RP, Bhoj V, Beatty GL, Ruella M. Manufacturing of CRISPR-edited primary mouse CAR T cells for cancer immunotherapy. Manufacturing of CRISPR-edited primary mouse CAR T cells for cancer immunotherapy. , Nat Protoc. : 2025


Lϋӧnd F, Whalen J, Song Y, Schriefer K, Newcombe R, Orlando EJ, Choi SM, Ruella M, Fraietta JA, Schuster SJ, Brogdon JL, Niederst MJ, Treanor LM. DLBCL cells emerge post CD19 CAR-T with cross-antigen resistance and a gene signature predictive of clinical CAR-T response. , Blood Cancer Discov.: 2025


Sullivan RJ, Cillo AR, Ferris RL, Jenkins RW, Kluger HM, Kok M, Lipson EJ, Paruzzo L, Redmond WL, Ruella M, Schalper KA, Thommen DS, Tolley K, Yarchoan M, Garnett-Benson C. SITC vision: Opportunities for deeper understanding of mechanisms of anti-tumor activity, toxicity, and resistance to optimize cancer immunotherapy. , J Immunother Cancer.: 2025


Lϋӧnd F, Whalen J, Song Y, Schriefer K, Newcombe R, Orlando EJ, Choi SM, Ruella M, Fraietta JA, Schuster SJ, Brogdon JL, Niederst MJ, Treanor LM. DLBCL cells emerge post CD19 CAR-T with cross-antigen resistance and a gene signature predictive of clinical CAR-T response. , Blood Cancer Discov.: 2025


Monette A, Aguilar-Mahecha A, Altinmakas E, Angelos MG, Assad N, Batist G, Bommareddy PK, Bonilla DL, Borchers CH, Church SE, Ciliberto G, Cogdill AP, Fattore L, Hacohen N, Haris M, Lacasse V, Lie WR, Mehta A, Ruella M, Sater S, Spatz A, Taouli B, Tarhoni I, Gonzalez-Kozlova E, Tirosh I, Wang X, Gnjatic S. The Society for Immunotherapy of Cancer Perspective on Liquid Biopsy- and Radiomics-Based Technologies for Immuno-oncology Biomarker Discovery and Application. , Clin Cancer Res., 31(12): 2025,2278-2293


Ahmed SO, El Fakih R, Kharfan-Dabaja MA, Syed F, Mufti G, Chabannon C, Rondelli D, Mohty M, Al Ahmari AA, Gauthier J, Ruella M, Perales MA, Hashmi S, Alfraih F, Ghorashian S, Alzahrani M, Abba Z, Koh M, Pasquini M, Ruggeri A, Garderet L, Albabtain A, Weisdorf D, Greinix H, Samarkandi H, Hamad N, Atsuta Y, Hamadani M, Hari P, Majhail NS, Greco R, Alzahrani H, Sureda A, Yakoub-Agha I, Alahmari AD, Niederwieser D, Aljurf M. Setting up a Chimeric Antigen Receptor T Cell Therapy Program: A Framework for Delivery from the Worldwide Network for Blood & Marrow Transplantation. , Transplant Cell Ther.: 2025


Thomas Luo, Luca Paruzzo, Sandra P. Susanibar Adaniya, Alfred L. Garfall, Matthew Ho, Shivani Kapur, Ruella M, Edward Allen Stadtmauer, Federico Stella, Dan T. Vogl, Adam J. Waxman, and Adam D. Cohen. Disease response at apheresis and association with long-term outcomes following CAR-T cells for relapsed/refractory multiple myeloma (RRMM). , Journal of Clinical Oncology, 43(16): 2025


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