Kathleen E. O'Neill, MD, MTR
Reproductive Endocrinology and Infertility
Headshot of Kathleen E. O'Neill, MD, MTR

Kathleen E. O'Neill, MD, MTR

she/her/hers
Reproductive Endocrinology and Infertility
LGBTQ+ affirming provider
Accepting new patients
Sees patients age 15 through 65
Penn Fertility Care
Headshot of Kathleen E. O'Neill, MD, MTR
Penn Medicine Provider

About me

  • Co-Principal Investigator UNTIL Trial
  • Assistant Professor of Obstetrics and Gynecology at the Hospital of the University of Pennsylvania

Dr. O’Neill is an attending surgeon specializing in reproductive endocrinology and infertility. She also serves as an assistant professor of obstetrics and gynecology and is the co-principal investigator of the Uterus Transplant for Uterine Factor Infertility (UNTIL) Trial.

My education and training

  • University of Michigan Medical SchoolMedical School
  • Barnes-Jewish Hospital - Washington University, St. LouisResidency
  • University of Pennsylvania Health SystemFellowship
Watch video featuring Kathleen E. O'Neill, MD, MTR on YouTube

Spoken languages

English
English
Español
Spanish

Reviews

Average Rating

127 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Anonymous
September 2026
Dr O'Neill has been wonderful.
Anonymous
September 2026
I felt like I could trust her
Anonymous
September 2026
New ideas about treatment
Anonymous
August 2026
it was a great experience

Insurance accepted

Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.

Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Lancaster General Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
Dr. O'Neill is a Penn Medicine physician.

Qualifications and experience

Treatments and conditions

Research

Publications

Thorup JR, Johnston SA, Haines M, Rush MA, Sedodo E, Kathleen O'Neill, Drapkin R, Udeshi ND, Gillette MA, Carr SA, Satpathy S Microscaled Cell Surface Proteomics for Cryo-preserved Cells and Tissue Samples. , Mol Cell Proteomics, 24(12):101437: 2025


Applebaum J, Zhao D, Latif N, O'Neill K Feasibility of Near-Infrared Spectroscopy for Monitoring Tissue Oxygenation During Uterus Transplantation and Hysterectomy. , J Clin Med, 14(14): 2025,4832


Yano Maher JC, Zelinski MB, Oktay KH, Duncan FE, Segars JH, Lujan ME, Lou H, Yun BH, Hanfling SN, Schwartz LE, Laronda MM, Halvorson LM, O'Neill KE, Gomez-Lobo V Classification system of human ovarian follicle morphology: recommendations of the National Institute of Child Health and Human Development - sponsored ovarian nomenclature workshop. , Fertil Steril, 123(5):761-778: 2025


Walter JR, Richards EG, Johannesson L, Falcone T, Jungheim E, Testa G, O'Neill KE, Harvie HS Cost-effectiveness analysis of uterus transplantation vs. gestational carrier for treatment of absolute uterine factor infertility in the United States. , Fertil Steril, S0015-0282(25): 2025,00035-4


Johannesson L, Humphries LA, Porrett PM, Testa G, Anderson S, Walter JR, Rush M, Ferrando CA, O'Neill K, Richards EG Classification and treatment of vaginal strictures at the donor-recipient anastomosis after uterus transplant. , Fertil Steril, 122(3):525-534: 2024


Walter JR, Johannesson L, Falcone T, Putnam JM, Testa G, Richards EG, O'Neill KE In Vitro Fertilization Practice in Patients with Absolute Uterine Factor Undergoing Uterus Transplant in the United States. , Fertil Steril, 122(3):397-405: 2024


Herz C, Vergnet N, Tian S, Aly AH, Jolley MA, Tran N, Arenas G, Lasso A, Schwartz N, O'Neill KE, Yushkevich PA, Pouch AM Open-source graphical user interface for the creation of synthetic skeletons for medical image analysis. , J Med Imaging (Bellingham), 11(3): 2024,036001


Johannesson L, Sawinski D, Vock DM, Kristek J, Fronek J, Richards EG, O'Neill KE, Perni U, Porrett PM, Testa G A Multi-Institutional Report of Intermediate-Term Kidney Outcomes in Uterus Transplant Recipients. , Kidney Int Rep, 8(10): 2156-2159: 2023


Fisher SA, Grijalva M, Guo R, Johnston SA, Laurent LC, Nguyen H, Renz J, Rosario JG, Rudich S, Gregory BD, Kim J, O'Neill K Systematic Sampling of the Female Reproductive System for Molecular Characterization. , Curr Protoc, 3(8): 2023,e848


Johannesson L, Testa G, Beshara MM, da Graca B, Walter JR, Quintini C, Latif N, Hashimoto K, Richards EG, O'Neill K Awareness and Interest in Uterus Transplantation over Time: Analysis of Those Seeking Surgical Correction for Uterine-Factor Infertility in the US. , J Clin Med, 12(13): 2023,4201