Description of Research Expertise:
My research is focused on translational studies of clinical and genetic risk factors for Primary Graft Dysfunction (PGD) and chronic rejection after lung transplantation. In addition to increased perioperative mortality, patients recovering from severe PGD have decreased quality of life and an increase risk of chronic rejection, the leading obstacle to long term survival after lung transplantation. Therefore, studies of the mechanisms of PGD and BOS will have a significant impact on the field of lung transplantation and may lead to therapies that improve the overall survival of lung transplant recipients. My current primary research interest is evaluating the role of innate immune activation in the development of post-lung transplant PGD and chronic rejection. I am also actively involved in integrating data on differential innate immune activation with the expanding body of knowledge on microbial colonization and infection of the lower respiratory tract as part of our evaluation of the microbiome of lung transplant recipients
Negorev Dmitri, Beier Ulf H, Zhang Tianyi, Quatromoni Jon G, Bhojnagarwala Pratik, Albelda Steven M, Singhal Sunil, Eruslanov Evgeniy, Lohoff Falk W, Levine Matthew H, Diamond Joshua M, Christie Jason D, Hancock Wayne W, Akimova Tatiana: Human neutrophils can mimic myeloid-derived suppressor cells (PMN-MDSC) and suppress microbead or lectin-induced T cell proliferation through artefactual mechanisms. Scientific reports 8 (1): 3135,2018.
Courtwright Andrew M, Zaleski Derek, Gardo Lisa, Ahya Vivek N, Christie Jason D, Crespo Maria, Hadjiliadis Denis, Lee James, Molina Maria, Patel Namrata, Porteous Mary, Cantu Edward E, Bermudez Christian, Diamond Joshua M: Causes, Preventability, and Cost of Unplanned Rehospitalizations Within 30 Days of Discharge Following Lung Transplantation. Transplantation : 2018.
Shaver Ciara M, Wickersham Nancy, McNeil J Brennan, Nagata Hiromasa, Miller Adam, Landstreet Stuart R, Kuck Jamie L, Diamond Joshua M, Lederer David J, Kawut Steven M, Palmer Scott M, Wille Keith M, Weinacker Ann, Lama Vibha N, Crespo Maria M, Orens Jonathan B, Shah Pali D, Hage Chadi A, Cantu Edward, Porteous Mary K, Dhillon Gundeep, McDyer John, Bastarache Julie A, Christie Jason D, Ware Lorraine B: Cell-free hemoglobin promotes primary graft dysfunction through oxidative lung endothelial injury. JCI insight 3 (2): 2018.
Siddiqui Faisal M, Diamond Joshua M: Lung transplantation for chronic obstructive pulmonary disease: past, present, and future directions. Current opinion in pulmonary medicine 24 (2): 199-204,2018.
Shah Rupal J, Diamond Joshua M: Update in Chronic Lung Allograft Dysfunction. Clinics in chest medicine 38 (4): 677-692,2017.
Ahya Vivek N, Diamond Joshua M: Pulmonary Considerations in Solid Organ and Hematopoietic Stem Cell Transplantation. Clinics in chest medicine 38 (4): xv-xvi,2017.
Diamond Joshua M, Ramphal Kristy, Porteous Mary K, Cantu Edward, Christie Jason D, Kawut Steven M: Association of long pentraxin-3 with pulmonary hypertension and primary graft dysfunction in lung transplant recipients. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation : 2017.
Cotter Elizabeth K Healy, Banayan Jennifer M, Song Tae H, Chaney Mark A, Ko Hanjo, Cantu Edward, Diamond Joshua, Weiss Stuart J, Cypel Marcelo, Keshavjee Shaf: Lung in a Box: Ex Vivo Lung Transplantation. Journal of cardiothoracic and vascular anesthesia : 2017.
Courtwright A, Diamond J M, Wood I, Guleria I, Milford E, El-Chemaly S, Goldberg H J: Detection and clinical impact of human leukocyte antigen antibodies in lung transplantation: A systematic review and meta-analysis. HLA 91 (2): 102-111,2018.
Cantu Edward, Diamond Joshua M, Suzuki Yoshikazu, Lasky Jared, Schaufler Christian, Lim Brian, Shah Rupal, Porteous Mary, Lederer David J, Kawut Steven M, Palmer Scott M, Snyder Laurie D, Hartwig Matthew G, Lama Vibha N, Bhorade Sangeeta, Bermudez Christian, Crespo Maria, McDyer John, Wille Keith, Orens Jonathan, Shah Pali D, Weinacker Ann, Weill David, Wilkes David, Roe David, Hage Chadi, Ware Lorraine B, Bellamy Scarlett L, Christie Jason D: Quantitative Evidence for Revising the Definition of Primary Graft Dysfunction After Lung Transplant. American journal of respiratory and critical care medicine : 2017.