Description of Research Expertise:
My research is focused on translational studies of clinical and genetic risk factors for Primary Graft Dysfunction (PGD) and chronic rejection after lung transplantation. In addition to increased perioperative mortality, patients recovering from severe PGD have decreased quality of life and an increase risk of chronic rejection, the leading obstacle to long term survival after lung transplantation. Therefore, studies of the mechanisms of PGD and BOS will have a significant impact on the field of lung transplantation and may lead to therapies that improve the overall survival of lung transplant recipients. My current primary research interest is evaluating the role of innate immune activation in the development of post-lung transplant PGD and chronic rejection. I am also actively involved in integrating data on differential innate immune activation with the expanding body of knowledge on microbial colonization and infection of the lower respiratory tract as part of our evaluation of the microbiome of lung transplant recipients
Diamond Joshua M, Cantu Edward, Porteous Mary, Suzuki Yoshikazu, Meyer Keith C, Lederer David, Milewski Rita K, Arcasoy Selim, D'Ovidio Frank, Bacchetta Matthew, Sonett Joshua R, Singh Gopal, Costa Joseph, Tobias John W, Rodriguez Hetty, Van Deerlin Vivianna M, Olthoff Kim M, Shaked Abraham, Chang Bao-Li, Christie Jason D: Peripheral Blood Gene Expression Changes Associated with Primary Graft Dysfunction after Lung Transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons : 2017.
Diamond Joshua Matthew: Predicting Primary Graft Dysfunction After Lung Transplantation: Trying to Catch It Early. Transplantation 101 (1): 21-22,2017.
Tong Yubing, Udupa Jayaram K, Torigian Drew A, Odhner Dewey, Wu Caiyun, Pednekar Gargi, Palmer Scott, Rozenshtein Anna, Shirk Melissa A, Newell John D, Porteous Mary, Diamond Joshua M, Christie Jason D, Lederer David J: Chest Fat Quantification via CT Based on Standardized Anatomy Space in Adult Lung Transplant Candidates. PloS one 12 (1): e0168932,2017.
Borders Catherine F, Suzuki Yoshikazu, Lasky Jared, Schaufler Christian, Mallem Djamila, Lee James, Carney Kevin, Bellamy Scarlett L, Bermudez Christian A, Localio A Russell, Christie Jason D, Diamond Joshua M, Cantu Edward: Massive donor transfusion potentially increases recipient mortality after lung transplantation. The Journal of thoracic and cardiovascular surgery : 2016.
Abbas A A, Diamond J M, Chehoud C, Chang B, Kotzin J J, Young J C, Imai I, Haas A R, Cantu E, Lederer D J, Meyer K, Milewski R K, Olthoff K M, Shaked A, Christie J D, Bushman F D, Collman R G: The Perioperative Lung Transplant Virome: Torque Teno Viruses are Elevated in Donor Lungs and Show Divergent Dynamics In Primary Graft Dysfunction. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons : 2016.
Diamond Joshua M, Arcasoy Selim, McDonnough Jamiela A, Sonett Joshua R, Bacchetta Matthew, D'Ovidio Frank, Cantu Edward, Bermudez Christian A, McBurnie Amika, Rushefski Melanie, Kalman Laurel H, Oyster Michelle, D'Errico Carly, Suzuki Yoshikazu, Giles Jon T, Ferrante Anthony, Lippel Matthew, Singh Gopal, Lederer David J, Christie Jason D: Adipose Gene Expression Profile Changes with Lung Allograft Reperfusion. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 17 (1): 239-245,2016.
Monticelli Laurel A, Buck Michael D, Flamar Anne-Laure, Saenz Steven A, Tait Wojno Elia D, Yudanin Naomi A, Osborne Lisa C, Hepworth Matthew R, Tran Sara V, Rodewald Hans-Reimer, Shah Hardik, Cross Justin R, Diamond Joshua M, Cantu Edward, Christie Jason D, Pearce Erika L, Artis David: Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation. Nature immunology 17 (6): 656-65,2016.
Purnema Madahar, Jonathan P. Singer, Jessica Sell, Patricia Katz, Jeffrey A. Golden, Hilary Y. Robbins, Lori Shah, Kashif Raza, Jaime Hook, Matthew Bacchetta, Frank D'Ovidio, Joshua R. Sonett, Jasleen Kukreja, Lorriana Leard, Steven Hays, Selim Arcasoy, Joshua M. Diamond, Jason D. Christie, David J. Lederer: Body Composition Phenotypes in Adults Awaiting Lung Transplantation American Journal of Respiratory and Critical Care Medicine 193 : A4664,2016.
Joshua M. Diamond, Selim Arcasoy, Jamiela McDonnough, Edward Cantu, Joshua R. Sonett, Matthew Bacchetta, Frank D'Ovidio, Christian A. Bermudez, Amika McBurnie, Melanie Rushefski, Yoshikazu Suzuki, Jon Giles, Michelle Oyster, Carly D'Errico, Anthony Ferrante, Matthrw Lippel, Gopal Singh, Jason D. Christie, David J. Lederer: Adipose Gene Expression Profile Changes with Lung Allograft Reperfusion American Journal of Respiratory and Critical Care Medicine 193 : A4680,2016.
Brian J. Anderson, Colin Christie, Ryan Tino, Kristy Ramphal, Alex Wysoczanski, Miranda Theodore, Nancy Blumenthal, Jaclyn Golato, Eric Hobson, Kevin Carney, James Mendez, Christian A. Bermudez, Edward Cantu, Joshua M. Diamond: Neuron Specific Enolase Is an Early Marker of Delirium Following Lung Transplantation American Journal of Respiratory and Critical Care Medicine 193 : A4672,2016.