Description of Research Expertise:
My research is focused on translational studies of clinical and genetic risk factors for Primary Graft Dysfunction (PGD) and chronic rejection after lung transplantation. In addition to increased perioperative mortality, patients recovering from severe PGD have decreased quality of life and an increase risk of chronic rejection, the leading obstacle to long term survival after lung transplantation. Therefore, studies of the mechanisms of PGD and BOS will have a significant impact on the field of lung transplantation and may lead to therapies that improve the overall survival of lung transplant recipients. My current primary research interest is evaluating the role of innate immune activation in the development of post-lung transplant PGD and chronic rejection. I am also actively involved in integrating data on differential innate immune activation with the expanding body of knowledge on microbial colonization and infection of the lower respiratory tract as part of our evaluation of the microbiome of lung transplant recipients
Purnema Madahar, Jonathan P. Singer, Jessica Sell, Patricia Katz, Jeffrey A. Golden, Hilary Y. Robbins, Lori Shah, Kashif Raza, Jaime Hook, Matthew Bacchetta, Frank D'Ovidio, Joshua R. Sonett, Jasleen Kukreja, Lorriana Leard, Steven Hays, Selim Arcasoy, Joshua M. Diamond, Jason D. Christie, David J. Lederer: Body Composition Phenotypes in Adults Awaiting Lung Transplantation American Journal of Respiratory and Critical Care Medicine 193 : A4664,2016.
Joshua M. Diamond, Selim Arcasoy, Jamiela McDonnough, Edward Cantu, Joshua R. Sonett, Matthew Bacchetta, Frank D'Ovidio, Christian A. Bermudez, Amika McBurnie, Melanie Rushefski, Yoshikazu Suzuki, Jon Giles, Michelle Oyster, Carly D'Errico, Anthony Ferrante, Matthrw Lippel, Gopal Singh, Jason D. Christie, David J. Lederer: Adipose Gene Expression Profile Changes with Lung Allograft Reperfusion American Journal of Respiratory and Critical Care Medicine 193 : A4680,2016.
Brian J. Anderson, Colin Christie, Ryan Tino, Kristy Ramphal, Alex Wysoczanski, Miranda Theodore, Nancy Blumenthal, Jaclyn Golato, Eric Hobson, Kevin Carney, James Mendez, Christian A. Bermudez, Edward Cantu, Joshua M. Diamond: Neuron Specific Enolase Is an Early Marker of Delirium Following Lung Transplantation American Journal of Respiratory and Critical Care Medicine 193 : A4672,2016.
C. D’Errico, M. Hotz, E. Cantu, M. Porteous, M. Oyster, R. Shah, S. Arcasoy, L. Snyder, K.M. Wille, M. Hartwig, L.B. Ware, P. Shah, M. Crespo, C. Hage, A. Weinacker, V. Lama, Y. Suzuki, J. Orens, S. Kawut, S. Palmer, D.J. Lederer, J.D. Christie, N. Mangalmurti, J.M. Diamond: Plasma RIP3 Is Decreased in PGD after Lung Transplantation The Journal of Heart and Lung Transplantation 35 (4): S87,2016.
C. Borders, Y. Suzuki, C. Schaufler, J. Lasky, D. Mallem, J. Lee, K. Carney, C. Bermudez, J. Diamond, J. Christie, E. Cantu: Massive Donor Transfusion Increases Recipient Early Mortality after Lung Transplantation The Journal of Heart and Lung Transplantation 35 (4): S370,2016.
E. Cantu, J. Diamond, J. Nellen, B. Beduhn, Y. Suzuki, C. Borders, J. Lasky, C. Schaufler, R. Shah, M. Porteous, D.J. Lederer, S.M. Kawut, S. Arcasoy, S.M. Palmer, L. Snyder, M.G. Hartwig, V.N. Lama, M. Crespo, K. Wille, J. Orens, P.D. Shah, A. Weinacker, L.B. Ware, S.L. Bellamy, J.D. Christie: Redefining Primary Graft Dysfunction after Lung Transplantation The Journal of Heart and Lung Transplantation 35 (4): S89,2016.
Cantu E, Suzuki Y, Diamond J M, Ellis J, Tiwari J, Beduhn B, Nellen J R, Shah R, Meyer N J, Lederer D J, Kawut S M, Palmer S M, Snyder L D, Hartwig M G, Lama V N, Bhorade S, Crespo M, Demissie E, Wille K, Orens J, Shah P D, Weinacker A, Weill D, Wilkes D, Roe D, Ware L B, Wang F, Feng R, Christie J D: Protein Quantitative Trait Loci Analysis Identifies Genetic Variation in the Innate Immune Regulator TOLLIP in Post-Lung Transplant Primary Graft Dysfunction Risk. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 16 (3): 833-40,2016.
Anderson Brian J, Diamond Joshua M: Under Pressure: Reduced Cerebral Perfusion as a Risk Factor for Postoperative Delirium in Lung Transplant Recipients. Annals of the American Thoracic Society 13 (2): 156-7,2016.
Diamond J M, Shah R J, Cantu E, Porteous M K, Christie J D: Survey of Lung Transplant Community's Views on Primary Graft Dysfunction. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 16 (2): 724-6,2016.
Porteous Mary K, Ky Bonnie, Kirkpatrick James N, Shinohara Russell, Diamond Joshua M, Shah Rupal J, Lee James C, Christie Jason D, Kawut Steven M: Diastolic Dysfunction Increases the Risk of Primary Graft Dysfunction After Lung Transplantation. American journal of respiratory and critical care medicine : 2016.