Description of Research Expertise:
My research is focused on translational studies of clinical and genetic risk factors for Primary Graft Dysfunction (PGD) and chronic rejection after lung transplantation. In addition to increased perioperative mortality, patients recovering from severe PGD have decreased quality of life and an increase risk of chronic rejection, the leading obstacle to long term survival after lung transplantation. Therefore, studies of the mechanisms of PGD and BOS will have a significant impact on the field of lung transplantation and may lead to therapies that improve the overall survival of lung transplant recipients. My current primary research interest is evaluating the role of innate immune activation in the development of post-lung transplant PGD and chronic rejection. I am also actively involved in integrating data on differential innate immune activation with the expanding body of knowledge on microbial colonization and infection of the lower respiratory tract as part of our evaluation of the microbiome of lung transplant recipients
T.I. Carter, Y. Suzuki, J. Lasky, C. Schaufler, B. Lim, D. Mallem, C.A. Bermudez, J.M. Diamond, J.D. Christie, X. Yu, R. Feng, E. Cantu: An In Situ Donor Derived Panel of Innate Immune Transcripts Predicts Primary Graft Dysfunction in Lung Transplant Recipients The Journal of Heart and Lung Transplantation 36 (4): S145-146,2017.
Baldwin Matthew R, Singer Jonathan P, Huang Debbie, Sell Jessica, Gonzalez Wendy C, Pollack Lauren, Maurer Mathew S, D'Ovidio Frank F, Bacchetta Matthew, Sonett Joshua R, Arcasoy Selim M, Shah Lori, Robbins Hilary, Hays Steven R, Kukreja Jasleen, Greenland John R, Shah Rupal J, Leard Lorriana, Morrell Matthew, Gries Cynthia, Katz Patricia P, Christie Jason D, Diamond Joshua M, Lederer David J: Refining Low Physical Activity Measurement Improves Frailty Assessment in Advanced Lung Disease and Survivors of Critical Illness. Annals of the American Thoracic Society : 2017.
C.A. Bermudez, M.R. Molina, A.M. Thomasson, E. Blumberg, J. Lee, L. Gardo, V. Ahya, N. Blumenthal, E. Cantu, J.D. Christie, A. Courtwright, J. Diamond, J. Golato, D. Hadjiliadis, E.J. Hobson, N. Patel, M. Porteous, M. Crespo: Lung Transplant Experience with Public Health Services Increased Risk Donors: Recipient Outcomes and Incidence of Transmission and Conversion The Journal of Heart and Lung Transplantation 36 (4): S52,2017.
B. Lim, J. Lasky, C. Schaufler, Y. Suzuki, D. Mallem, M. Molina, C. A. Bermudez, J. M. Diamond, J. D. Christie, E. Cantu.: Lung Allocation Score Implementation Narrowed Racial/Ethnic Disparities in Adult Lung Transplantation Outcomes The Journal of Heart and Lung Transplantation 36 (4): S17,2017.
A. Courtwright, D. Zaleski, V. Ahya, C. Bermudez, N. Blumenthal, E. Cantu, J. Christie, T. Claridge, M. Crespo, J. Golato, D. Hadjiliadis, E. Hobson, J. Lee, M. Molina, N. Patel, M. Porteous, J. Diamond: Causes and Preventability of Unplanned Rehospitalization Following Lung Transplantation The Journal of Heart and Lung Transplantation 36 (4): 2017.
C. Schaufler, J. Lasky, B. Lim, Y. Suzuki, D. Mallem, M. Oyster, D.J. Lederer, K. Meyer, C.A. Bermudez, J. Tobias, V.M. Van Deerlin, K. Olthoff, A. Shaked, J.M. Diamond, E. Cantu, J.D. Christie
: Gene Set Enrichment Analysis Identifies a Potential Link Between Smoking and Upregulation of Olfactory Receptor and Cytokine Enrichment Pathways The Journal of Heart and Lung Transplantation 36 (4): S417,2017.
Narayan Vivek, Deshpande Charuhas, Bermudez Christian A, Golato Jaclyn M, Lee James C, Diamond Joshua, Vaughn David J: Bilateral Lung Transplantation for Bleomycin-Associated Lung Injury. The oncologist : 2017.
Vallabhajosyula Prashanth, Korutla Laxminarayana, Habertheuer Andreas, Reddy Sanjana, Schaufler Christian, Lasky Jared, Diamond Joshua, Cantu Edward: Ex Vivo Lung Perfusion Model to Study Pulmonary Tissue Extracellular Microvesicle Profiles. The Annals of thoracic surgery : 2017.
Diamond Joshua M, Cantu Edward, Porteous Mary, Suzuki Yoshikazu, Meyer Keith C, Lederer David, Milewski Rita K, Arcasoy Selim, D'Ovidio Frank, Bacchetta Matthew, Sonett Joshua R, Singh Gopal, Costa Joseph, Tobias John W, Rodriguez Hetty, Van Deerlin Vivianna M, Olthoff Kim M, Shaked Abraham, Chang Bao-Li, Christie Jason D: Peripheral Blood Gene Expression Changes Associated with Primary Graft Dysfunction after Lung Transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons : 2017.
Diamond Joshua Matthew: Predicting Primary Graft Dysfunction After Lung Transplantation: Trying to Catch It Early. Transplantation 101 (1): 21-22,2017.