Description of Research Expertise:
My research is focused on translational studies of clinical and genetic risk factors for Primary Graft Dysfunction (PGD) and chronic rejection after lung transplantation. In addition to increased perioperative mortality, patients recovering from severe PGD have decreased quality of life and an increase risk of chronic rejection, the leading obstacle to long term survival after lung transplantation. Therefore, studies of the mechanisms of PGD and BOS will have a significant impact on the field of lung transplantation and may lead to therapies that improve the overall survival of lung transplant recipients. My current primary research interest is evaluating the role of innate immune activation in the development of post-lung transplant PGD and chronic rejection. I am also actively involved in integrating data on differential innate immune activation with the expanding body of knowledge on microbial colonization and infection of the lower respiratory tract as part of our evaluation of the microbiome of lung transplant recipients
Siddiqui Faisal M: Lung transplantation for chronic obstructive pulmonary disease: past, present, and future directions. Current opinion in pulmonary medicine : 2017.
Shah Rupal J: Update in Chronic Lung Allograft Dysfunction. Clinics in chest medicine 38 (4): 677-692,2017.
Ahya Vivek N: Pulmonary Considerations in Solid Organ and Hematopoietic Stem Cell Transplantation. Clinics in chest medicine 38 (4): xv-xvi,2017.
Courtwright A, Diamond J M, Wood I, Guleria I, Milford E, El-Chemaly S: Detection and clinical impact of human leukocyte antigen antibodies in lung transplantation: A systematic review and meta-analysis. HLA : 2017.
Cantu Edward, Diamond Joshua M, Suzuki Yoshikazu, Lasky Jared, Schaufler Christian, Lim Brian, Shah Rupal, Porteous Mary, Lederer David J, Kawut Steven M, Palmer Scott M, Snyder Laurie D, Hartwig Matthew G, Lama Vibha N, Bhorade Sangeeta, Bermudez Christian, Crespo Maria, McDyer John, Wille Keith, Orens Jonathan, Shah Pali D, Weinacker Ann, Weill David, Wilkes David, Roe David, Hage Chadi, Ware Lorraine B, Bellamy Scarlett L: Quantitative Evidence for Revising the Definition of Primary Graft Dysfunction After Lung Transplant. American journal of respiratory and critical care medicine : 2017.
Akimova Tatiana, Zhang Tianyi, Negorev Dmitri, Singhal Sunil, Stadanlick Jason, Rao Abhishek, Annunziata Michael, Levine Matthew H, Beier Ulf H, Diamond Joshua M, Christie Jason D, Albelda Steven M, Eruslanov Evgeniy B: Human lung tumor FOXP3+ Tregs upregulate four "Treg-locking" transcription factors. JCI insight 2 (16): 2017.
Diamond Joshua M, Arcasoy Selim, Kennedy Cassie C, Eberlein Michael, Singer Jonathan P, Patterson Glenda M, Edelman Jeffrey D, Dhillon Gundeep, Pena Tahuanty, Kawut Steven M, Lee James C, Girgis Reda, Dark John: Report of the International Society for Heart and Lung Transplantation Working Group on Primary Lung Graft Dysfunction, part II: Epidemiology, risk factors, and outcomes-A 2016 Consensus Group statement of the International Society for Heart and Lung Transplantation. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation : 2017.
Porteous Mary K, Lee James C, Lederer David J, Palmer Scott M, Cantu Edward, Shah Rupal J, Bellamy Scarlett L, Lama Vibha N, Bhorade Sangeeta M, Crespo Maria M, McDyer John F, Wille Keith M, Localio A Russell, Orens Jonathan B, Shah Pali D, Weinacker Ann B, Arcasoy Selim, Wilkes David S, Ware Lorraine B, Christie Jason D, Kawut Steven M: Clinical Risk Factors and Prognostic Model for Primary Graft Dysfunction after Lung Transplantation in Patients with Pulmonary Hypertension. Annals of the American Thoracic Society : 2017.
Vallabhajosyula Prashanth, Korutla Laxminarayana, Habertheuer Andreas, Reddy Sanjana, Schaufler Christian, Lasky Jared, Diamond Joshua: Ex Vivo Lung Perfusion Model to Study Pulmonary Tissue Extracellular Microvesicle Profiles. The Annals of thoracic surgery 103 (6): 2017.
Abbas A A, Diamond J M, Chehoud C, Chang B, Kotzin J J, Young J C, Imai I, Haas A R, Cantu E, Lederer D J, Meyer K, Milewski R K, Olthoff K M, Shaked A, Christie J D, Bushman F D: The Perioperative Lung Transplant Virome: Torque Teno Viruses are Elevated in Donor Lungs and Show Divergent Dynamics In Primary Graft Dysfunction. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 17 (5): 1313-24,2017.