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Jay A. Gottfried, MD, PHD

Jay A. Gottfried, MD, PHD Physician

Professor of Neurology

Dr. Gottfried is employed by Penn Medicine.

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Clinical Specialties


  • Neurology

Programs & Centers:

Board Certification:

  • Neurology, 2003

Clinical Expertise:

  • Alzheimer's Disease
  • Anterograde Amnesia
  • Behavioral Issues in Dementia
  • Chronic Traumatic Encephalopathy
  • Cognitive Impairment
  • Corticobasal Syndrome (CBS)
  • Diagnostic Test
  • Expressive Language Disorder
  • Frontal Lobe Disinhibition
  • Lewy Body Dementia
  • Memory Disorders
  • Mild Cognitive Impairment
  • Neurodegenerative Diseases
  • Neuropsychological Assessment
  • Pick's Disease
  • Progressive Supranuclear Palsy (PSP)
  • Vascular Neurocognitive Disorder

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: New York University School of Medicine
Residency: Mount Sinai Medical Center
Residency: Hospital of the University of Pennsylvania


Agence Nationale de la Recherché (France), International American Neurological Association, National Imaging/Science Track Award for Research Transition, National Institutes of Health/National Institute on Drug Abuse, National National Science Foundation, National Society for Neuroscience, International

Hospital Affiliation

Dr. Gottfried is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Research Interests:
Our lab focuses on understanding how the human brain transforms olfactory inputs into perceptual representations, and how learning, memory, and experience modulate this information to enhance odor object recognition and discrimination at the behavioral, cognitive, and neural levels.

Sensory Systems and Perception; Olfaction; Behavioral Neuroscience; Cognitive Neuroscience; Functional MRI; Intracranial EEG; Psychophysics; Neuroanatomy and Immunostaining

Research Details:
Our research can be thematically organized into three broad components ranging from the microscopic to the macroscopic: molecular and cellular analysis of human olfactory tissue; in vivo electrophysiological analysis using intracranial EEG recordings in patients with temporal lobe epilepsy; and systems-level analysis using functional MRI and olfactory psychophysical techniques in human subjects, and also in mouse subjects. Currently even the most well-founded research assumptions – the cellular organization of the peripheral olfactory system; the cortical projection pathways and centrifugal feedback connections; the physiological coding principles that underlie odor processing and memory consolidation – remain almost completely untested in humans. Together these different research strands support a consolidated research platform to investigate human olfaction with a neuroscientific breadth intended to connect the dots from molecules to mind, and from health to disease.

Academic Contact Info

Stellar-Chance Laboratories, 5th Floor
422 Curie Blvd

Philadelphia, PA 19104
Phone: (215) 573-8946
Patient appointments: 800-789-7366 (PENN)