Description of Research Expertise
Thormbosis, fibrinolysis, vascular biology, immunohematology
Selected Publications
Sarkar A, Khandelwal S, Koma G, Kim H, Gruel Y, Rollin J, Passam FH, Wool GD, Arepally GM, Cines DB, Rauova L, Poncz M.: Prevention of thrombocytopenia and thrombosis in HIT using deglycosylated KKO: a novel therapeutic? Blood Adv : 2023.
Cines DB, Greinacher A.: Vaccine-induced immune thrombotic thrombocytopenia Blood 141 : 1659-1665,2023.
Cai Z, Bdeir K, Yarovoi SV, Rauova L, Arepally GM, Khandelwal S, Rollin J, Gruel Y, Zaitsev S, Poncz M, Greene MI, Cines DB.: Modulation of ultralarge immune complexes in heparin-induced thrombocytopenia J Thromb Haemost : 2023.
Stepanov V, Zaitsev S, McGuckin J, Saiyed A, Lin D, Jiang L, Teos L, Goncharov D, Kudryashova T, Kowalska MA, Ahn H, Poncz M, Cines DB, Goncharova E.: Intrinsic deficiency of PAI-1 drives uPA-dependent cell proliferation in human pulmonary arterial smooth muscle cells (PASMCs) from pulmonary artery hypertension (PAH) patients and induces spontaneous pulmonary hypertension (PH) in mice. American Thoracic Society : 2023.
Sarkar A. Ngo AT, Khandelwat S, Gollomp K, Arepally G, Cines DB, Rauova L, Poncz M: Fc modified KKO blocks thrombosis in heparin-induced thrombocytopenia (HIT), but not in vaccine-induced thrombocytopenia and thrombosis (VITT) ISTH : 2023.
Rauova L, Oberg J, Field C, Levine N, Arepally HM, Cines DB, Cohen T, Poncz M: ChadOx exposure-induced neutrophil-activating peptide 2 (NAP2) antibodies: Murine-based insights into the pathgenesis of vaccine-induced immune thrombotic thrombocytopenia (VITT). ISTH : 2023.
Myoung SS, Khandelwal S, Francis SJ, Poncz M, Cines, DF and Arepallu GM: Value of complement activating properties of heparin induced thrombocytopenia (HIT) antibodies as surrogate marker for a functional assay. ISTH : 2023.
Le HT, Golla K, Karimi R, Hughes MR, Lakschevitz F, Cines DB, Kowalska MA, Poncz M, McNagny KM, Häkkinen L, Kim H.: Platelet factor 4 (CXCL4/PF4) upregulates matrix metalloproteinase-2 (MMP-2) in gingival fibroblasts Sci Rep 12 : 18636,2022.
Canas JJ, Liang D, Saxena V, Hooks J, Arregui SW, Gao H, Liu Y, Kish D, Linn SC, Bdeir K, Cines DB, Fairchild RL, Spencer JD, Schwaderer AL, Hains DS.: Human neutrophil peptides 1-3 protect the murine urinary tract from uropathogenic Escherichia coli challenge Proc Natl Acad Sci U S A 119 : e2206515119,2022.
Rauova L, Cines DB.: Platelets get particular Blood 140 : 413-414,2022.
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Academic Contact Information
Dept. Pathology and Laboratory Medicine
513 A Stellar Chance
422 Curie Blvd.
University of Pennsylvania
Philadelphia,
PA
19104
Phone: 215-662-3966
Patient appointments: 800-789-7366