Description of Research Expertise
Thormbosis, fibrinolysis, vascular biology, immunohematology
Selected Publications
Rauova L, Oberg J, Gilbert S, Cines DB, Poncz M.: A murine model of vaccine-induced immune thrombotic thrombocytopenia (VITT) leads to anti-NAP2 and anti-PF4 antibodies and may involve TLR9 activation. ISTH : 2024.
Myoung S, Francis SJ, Chen J, Lee G, Rauova L, Poncz M, Cines DB, Kuchibhatla M, Khandelwal S, Arepally GM.: Complement Activation as a biomarker for platelet activating HIT antibodies. ASH 2024. ASH : 2024.
Field CO, Sarkar A, Bdeir Kh, McRae KR, Ortel TL, Kowalska MA, Rauova L, Cines DB, Gollomp K, Poncz M.: Antiphospholipid syndrome (APS) is a platelet factor 4 (PF4)-centric immunothrombotic disorder. ASH : 2024.
Sarkar A, Yadav SK, Field CO, Gollomp K, McCrae KM, Ortel T, Gruel Y, Rollen J, Arepally GM, Rauova L, Cines DB, Poncz M.: Anti-phospholipid syndrome (APS) antibody (Ab)-induced thrombosis can be blocked by platelet factor 4 (PF4)-directed Abs: A novel therapeutic for APS? ASH : 2024.
Ngo ATP, Skidmore A, Yarovoi I, Sarkar A, Levine ND, Bochenek V, Zhao G, Rauova L, Kowalska MA, Eckart K, Mangalmurti NS, Rux A, Cines DB, Poncz M, Gollomp K.: Platelet factor 4 limits neutrophil extracellular trap- and cell-free DNA-induced thrombogenicity and endothelial injury. JCI-Insight. 8 (22): 2023.
Bussel JM, Hou M, Cines DB.: Management of primary ITP in pregnancy. New Eng J Med. 389 (6): 540,2023.
Sarkar A, Khandelwal S, Koma G, Kim H, Gruel Y, Rollin J, Passam FH, Wool GD, Arepally GM, Cines DB, Rauova L, Poncz M.: Prevention of thrombocytopenia and thrombosis in HIT using deglycosylated KKO: a novel therapeutic? Blood Adv : 2023.
Cines DB, Greinacher A.: Vaccine-induced immune thrombotic thrombocytopenia Blood 141 : 1659-1665,2023.
Cai Z, Bdeir K, Yarovoi SV, Rauova L, Arepally GM, Khandelwal S, Rollin J, Gruel Y, Zaitsev S, Poncz M, Greene MI, Cines DB.: Modulation of ultralarge immune complexes in heparin-induced thrombocytopenia J Thromb Haemost : 2023.
Myoung SS, Khandelwal S, Francis SJ, Poncz M, Cines, DF and Arepallu GM: Value of complement activating properties of heparin induced thrombocytopenia (HIT) antibodies as surrogate marker for a functional assay. ISTH : 2023.
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Academic Contact Information
Dept. Pathology and Laboratory Medicine
513 A Stellar Chance
422 Curie Blvd.
University of Pennsylvania
Philadelphia,
PA
19104
Phone: 215-662-3966
Patient appointments: 800-789-7366