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Douglas B. Cines, MD

Douglas B. Cines, MD Physician

Director, Coagulation Laboratory
Director, Office of Faculty Development, Pathology and Laboratory Medicine
Professor of Pathology and Laboratory Medicine
Professor of Medicine

Dr. Cines is a Penn Medicine employed physician.

Clinical Specialties


  • Pathology and Laboratory Medicine

Programs & Centers:

Board Certification:

  • Hematology, 1980
  • Internal Medicine, 1975

Description of Clinical Expertise

Coagulation. Immune hematological disorders

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: New York University School of Medicine
Residency: University of North Carolina Hospitals
Fellowship: Hospital of the University of Pennsylvania


American Association for the Advancement of Science, National American Association for the Advancement of Science, National American Association of Immunologists, National American Federation for Clinical Research, National American Society of Hematology, National Federation of Clinical Immunology Societies, National International Society Hemostasis and Thrombosis, International Platelet Disorder Support Association, National

Hospital Affiliation

Dr. Cines is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Thormbosis, fibrinolysis, vascular biology, immunohematology

Selected Publications:

Husseinzadeh, H., Cuker, A., Lebeveda, T., Massefski, W., Marturano, J., Lowery, T., Abrams, C. and Cines, D.B.: T2MR platelet analysis agrees with LTA and enables facile detection of platelet disorders in microliter volumes of blood. THSNA : 2016.

Tutwiler, V., Madeeva, D., Ahn, H.S., Hayes, V., Cines, D.B., Zheng, X.L., McKenzie, S., Poncz, M., and Rauova, L.: Platelet transactivation by monocytes promotes the prothrombotic state in heparin-induced thrombocytopenia. Blood : 2016.

Cai Z, Zhu Z, Greene MI, Cines DB.: Atomic features of an autoantigen in heparin-induced thrombocytopenia (HIT). Autoimmun. : 2016.

Villa, C., Muzykantov, V., and Cines, D.B: The emerging role for red blood cells in hemostasis: Opportunity for intervention. International Society for Blood Transfusion Science Series : 2016.

Tutwiler, V., Litvinov, R.I., Lozhkin, A. P., Pershova, A.D., Lebedeva, T., Ataullakhanov, F.I., Spiller, K.L., Cines, D.B, and Weisel, J.W.: Kinetics and mechanics of clot contraction are governed by molecular and cellular blood composition. Blood : 2016.

Fuentes, R.E., Zaitsev, S., Ahn, H.-S., Hayes, V. H., Kowalska, M.A., Lambert, M.E., Wang, Y., Siegel, D. L., Bougie, D.W., Aster, R.H., Myers, D.D., Stepanova, V., Cines, D.B., Muzykantov, V.R. and Poncz, M.: A platelet-targeted urokinase prodrug as a novel thromboprophylactic agent. J. Clin. Invest : 2016.

Abu-Fanne, R., Maraga, E., Abd-Elrahman, I., Hankin, A., Blum, G., Basheer, Abdeen, S., Hijazi, N., Cines, D.B., and Higazi, A.A.-: -R ?--Defensin promotes vascular deposition of LDL. J. Biol. Chem : 2016.

Florova, G., Azghani, A.O., Karandashova, S., Schaefer, C., Yarovoi, S.V., Declerck, P.J., Cines, D.B., Idell, S., and Komissarov, A.A.: The slow rate of fibrinolysis limits inhibitor selection when targeting plasminogen activator inhibitor 1 to enhance intrapleural fibrinolytic therapy. American Thoracic Society : 2015.

Cines, D.B., Gernsheimer, T., Wasser, J., Godeau, B., Provan, D., Lyons, R., Altomare, I., Wang, X., and Lopez, A.: Integrated analysis of long-term safety in patients with chronic immune thrombocytopenic purpura (ITP) treated with the thrombopoetin (TPO) receptor agonist romiplostim. Int. J. Hematol. 102 (3): 259-270,2015.

Cai, Z., Yarovoi, S.V., Zhu, Z., Rauova, L., Hayes, V., Lebedeva, R., Li, Q., Poncz, M., Cines, D.B.* and Greene, M.I.* (*equal contribution).: Atomic description of the immune complex that causes heparin-induced thrombocytopenia. Nature Communic. : 2015.

Academic Contact Info

Dept. Pathology and Laboratory Medicine
513 A Stellar Chance
422 Curie Blvd.
University of Pennsylvania

Philadelphia, PA 19104
Phone: (215) 662-3966
Fax: (215) 573-2012
Patient appointments: 800-789-PENN (7366)

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