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Douglas B. Cines, MD

Douglas B. Cines, MD Physician

Director, Coagulation Laboratory
Director, Office of Faculty Development, Pathology and Laboratory Medicine
Professor of Pathology and Laboratory Medicine
Professor of Medicine

Dr. Cines is a Penn Medicine employed physician.

Clinical Specialties

Specialty:

  • Pathology and Laboratory Medicine

Programs & Centers:

Board Certification:

  • Hematology, 1980
  • Internal Medicine, 1975

Description of Clinical Expertise

Coagulation. Immune hematological disorders

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: New York University School of Medicine
Residency: University of North Carolina Hospitals
Fellowship: Hospital of the University of Pennsylvania

Memberships

American Association for the Advancement of Science, National American Association for the Advancement of Science, National American Association of Immunologists, National American Federation for Clinical Research, National American Society of Hematology, National Federation of Clinical Immunology Societies, National International Society Hemostasis and Thrombosis, International Platelet Disorder Support Association, National

Hospital Affiliation

Dr. Cines is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

Thormbosis, fibrinolysis, vascular biology, immunohematology

Selected Publications:

Ostertag, E.M., Bdeir K., Kacir S., Thiboutot, M., Gulendran, G., Yunk, L., Hayes, V.M., Poncz, M., Zheng, X.L., Cines, D.B. and Siegel, D.L.: ADAMTS13 Autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 2. Pathogenicity in an animal model. Transfusion 56 (7): 1775-85,2016.

Cai Z, Zhu Z, Greene MI, Cines DB.: Atomic features of an autoantigen in heparin-induced thrombocytopenia (HIT). Autoimmun. 15 (7): 752-5,2016.

Stepanova, V., Jayaraman, P.S., Zaitsev, S.V., Lebeda, T., Bdeir, Kh., Kershaw, R., Holman, K., Parfyonova, Y.V., Semina, E., Beloglazova, I., Boldyreva, M. Tkachuk, V.S. and Cines, D.B.: Urokinase-type plasminogen activator (uPA) promotes angiogenesis by attenuating proline-rich homeobox (PRH) transcription factor activity and de-repressing vascular endothelial cell growth factor (VEGF) receptor expression. J. Biol. Chem. 291 (29): 15029-45,2016.

Ostertag, E.M., Kacir, S., Thiboutot, M.C, Gueldran, G., Zheng, X. L., Cines, D.B. and Siegel, D.L.: ADAMTS13 Autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 1. Structural and functional characterization in vitro. Transfusion 56 (7): 1763-74,2016.

Parker, Z.F., Rux, A.H., Riblett, A.M., Lee, F.-H., Rauova, L., Cines, D.B., Poncz, M., Sachais, B.S., and Doms, R.W.: Platelet-Factor 4 (PF4) inhibits and enhances HIV-1 infection in a concentration-dependent manner by modulating viral attachment. AIDS Research and Human Retroviruses. 32 (7): 705-17,2016.

Cuker, A., Cines, D.B. and Neunert, C.E.: Controversies in the treatment of immune thrombocytopenia. Current Opinion in Hematology : 2016.

Pillai, V.G., Bao, J., Zander, C.B., McDaniel, J.K., Cao, W., Chetty, P.S., Seeholzer, S.G. Bdeir, Kh., Cines, D.B. and Zheng, X.L.: Human neutrophil peptides (HNPs) inhibit proteolytic cleavage of von Willebrand factor by ADAMTS13: a potential trigger for thrombotic thrombocytopenic purpura. Blood 128 (1): 110-9,2016.

Abu-Fanne, R., Adb-Elrahman, I., Hankin, A., Blum, G., Basheer, M., Hojazi, N., Cines, D.B., Maraga, E., and Higazi, A.A.-R: alpha-defensin promotes vascular deposition of LDL. J. Biol. Chem. 291 (6): 2777-86,2016.

Fuentes, R.E., Zaitsev, S., Ahn, H.-S., Hayes, V. H., Kowalska, M.A., Lambert, M.E., Wang, Y., Siegel, D. L., Bougie, D.W., Aster, R.H., Myers, D.D., Stepanova, V., Cines, D.B., Muzykantov, V.R. and Poncz, M.: A platelet-targeted urokinase prodrug as a novel thromboprophylactic agent. J. Clin. Invest 126 (2): 483-494,2016.

Tutwiler, V., Litvinov, R.I., Lozhkin, A. P., Pershova, A.D., Lebedeva, T., Ataullakhanov, F.I., Spiller, K.L., Cines, D.B, and Weisel, J.W.: Kinetics and mechanics of clot contraction are governed by molecular and cellular blood composition. Blood 127 (1): 149-59,2016.

Academic Contact Info

Dept. Pathology and Laboratory Medicine
513 A Stellar Chance
422 Curie Blvd.
University of Pennsylvania

Philadelphia, PA 19104
Phone: (215) 662-3966
Fax: (215) 573-2012
Patient appointments: 800-789-PENN (7366)

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