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Douglas B. Cines, MD

Douglas B. Cines, MD Physician

Director, Coagulation Laboratory Director, Office of Faculty Development, Pathology and Laboratory Medicine Professor of Medicine Professor of Pathology and Laboratory Medicine

Dr. Cines is employed by Penn Medicine.

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Clinical Specialties


  • Pathology and Laboratory Medicine

Programs & Centers:

Board Certification:

  • Hematology, 1980
  • Internal Medicine, 1975

Description of Clinical Expertise

Coagulation. Immune hematological disorders

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: New York University School of Medicine
Residency: University of North Carolina Hospitals
Fellowship: Hospital of the University of Pennsylvania


American Association for the Advancement of Science , National American Association of Immunologists , National American Federation for Clinical Research , National American Society of Hematology, National American Society of Hematology, National American Society of Hematology, National American Society of Hematology, National Federation of Clinical Immunology Societies, National Platelet Disorder Support Association, National

Hospital Affiliation

Dr. Cines is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Thormbosis, fibrinolysis, vascular biology, immunohematology

Selected Publications:

Greineder, C.F., Johnston, I.H., Villa, C.H., Golluop, K., Esmon, C.T., Cines, D.B., Poncz, M. and Muzykantov, V.R.: ICAM-1–targeted thrombomodulin mitigates tissue factor–driven inflammatory thrombosis in a human endothelialized microfluidic model Blood Advances 1 (18): 1452-65,2017.

Dai, J., Hayes, V., Johnston, I., Gollomp, K., Areaplly, G.M., Cines, D.B., Poncz, M. and Raouva, L.: Dynamic redistribution of platelet factor 4 on vascular and intravascular cell surfaces: Implications for heparin-induced thrombocytopenia (HIT). ISTH. Berlin, Germany : 2017.

Cines D.B., Levine L.D.: Thrombocytopenia in pregnancy Blood : 2017.

Andrianova, I., Hayes, V., Litvinov, R., Cines, D.B., Poncz, M., Weisel, J.W. and Rauova, L.: Pathogenic antibodies in heparin-induced thrombocytopenia (HIT) activate monocytes and induce profound membrane remodeling. ISTH. Berlin, Germany : 2017.

Johnston, I., Lopez, J, Cines, D.B., Raouva, L. and Poncz, M.: Platelet factor 4: Von Willebrand Factor Complexes: An Important Antigenic Target in Heparin-Induced Thrombocytopenia? ISTH. Berlin, Germany : 2017.

Bdeir, Kh., Mei, J., Gollomp, K., Stasiak, M., Zhou, G., Cines, D.B., Worthein, G.S., Poncz, M. and Kowalska, M.A.: Platelet-specific chemokines contribute to the pathogenesis of acute lung injury. American Journal of Respiratory Cell and Molecular Biology 56 (2): 261-270,2017.

Hayes V, Johnston I, Arepally GM, McKenzie SE, Cines DB, Rauova L, Poncz M.: Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia The Journal of Clinical Investigation 127 (3): 1090-1098,2017.

Villa, C., Cines, D.B., Siegel, D.L. and Muzykantov, V.: Erythrocytes as Carriers for Drug Delivery in Blood Transfusion and Beyond. Transfusion Medicine Reviews 31 (1): 26-35,2017.

Cuker, A., Husseinzadeh, H., Lebedeva, T., Martuano, J.E., Massefski, W., Lowery, T., Lambert, M.P., Abrams, C.S., Weisel, J.W. and Cines, D.B.: Rapid evaluation of platelet function with T2 magnetic resonance using microliter volumes of whole blood American Journal of Clinical Pathology 146 (6): 681-693,2017.

Cines, D. B., Wasser, J., Rodeghiero, F., Chong, B.H., Steurer, M., Provan, D., Lyons, R., Garcia, J., Carpenter, N., Wang, X., and Eisen, M.: Safety and efficacy of romiplostim in splenectomized and nonsplenectomized patients with primary immune thrombocytopenia. Haematologica 102 (8): 1342-51,2017.

Academic Contact Info

Dept. Pathology and Laboratory Medicine
513 A Stellar Chance
422 Curie Blvd.
University of Pennsylvania

Philadelphia, PA 19104
Phone: (215) 662-3966
Patient appointments: 800-789-7366 (PENN)

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