Maintaining the ends of chromosomes, called telomeres, allows cells to continuously divide and achieve immortality. “Telomeres are much like the plastic cap on the ends of shoelaces -- they keep the ends of DNA from fraying,” said Roger Greenberg, MD, PhD, an associate professor of Cancer Biology in the Perelman School of Medicine at the University of Pennsylvania. In a new study published this week in Nature, senior author Greenberg and colleagues have developed a first-of-its- kind system to observe repair to broken DNA in newly synthesized telomeres, an effort that has implications for designing new cancer drugs.

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