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Vesselin Tomov, MD, PhD

Vesselin Tomov, MD, PhD Physician

Assistant Professor of Medicine at the Hospital of the University of Pennsylvania

Dr. Tomov is employed by Penn Medicine.

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Clinical Specialties

Specialty:

  • Gastroenterology

Programs & Centers:

Board Certification:

  • Gastroenterology, 2013
  • Internal Medicine, 2011

Clinical Expertise:

  • Chronic Diarrhea
  • Crohn's Disease
  • Inflammatory Bowel Disease (IBD)
  • Ulcerative Colitis (Colitis Ulcerosa, UC)

Description of Clinical Expertise

Inflammatory bowel isease

Practice Locations and Appointments

  • Penn Gastroenterology

    Perelman Center for Advanced Medicine South Pavilion, 4th Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-7366 (PENN)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School:
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania

Memberships

American Association for the Study of Liver Diseases, National American Gastroenterological Association, National American Medical Association, National American Society for Gastrointestinal Endoscopy, National Crohn’s and Colitis Foundation of America, National The American Association of Immunologists, National

Hospital Affiliation

Dr. Tomov is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Radnor: Has privileges to perform procedures.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

Norovirus (NV) are major global pathogens associated with significant morbidity and mortality, yet there is no effective NV vaccine and we know little about NV immunity. Candidate vaccines have been ineffective despite eliciting strong antibody responses. Furthermore, NVs can cause persistent infections, challenging the long-held view that they are transient pathogens. Until recently there was little known about cellular immunity to NVs. Our research has focused on defining and tracking epitope-specific CD8 T cell responses during infection with acute and chronic strains of murine NV (MNV) to gain insight into mechanisms of viral clearance vs. persistence.

We used the MNV system to screen overlapping peptide libraries and define MHC class I and class II epitopes. We then tracked MNV specific CD8 T cells using MHC class I-peptide tetramers and uncovered key differences between T cell responses in acute vs. chronic MNV infection.

Selected Publications:

Vesselin T. Tomov, Olesya Palko, Chi Wai Lau, Yuhang Sun, Ralitza Tacheva, Bertram Bengsch, Sasikanth Manne, Gabriela L. Cosma, Laurence Eisenlohr, Timothy J. Nice, Herbert W. Virgin: Enteric MNV persistence is associated with a unique CD8 T cell differentiation state and rapid immune evasion Keystone Symposium : 2017.

Nice TJ, Osborne LC, Tomov VT, Artis D, Wherry EJ: Type I Interferon Receptor Deficiency in Dendritic Cells Facilitates Systemic Murine Norovirus Persistence Despite Enhanced Adaptive Immunity PLos Pathogen 12 (6): e1005684,2016.

Vesselin Tomov, Olesya Palko: Human Norovirus-specific T Cell Responses Center for Molecular Studies in Digestive and Liver Diseases at the University of Pennsylvania 2015 Symposium : 2015.

Osborne Lisa C, Monticelli Laurel A, Nice Timothy J, Sutherland Tara E, Siracusa Mark C, Hepworth Matthew R, Tomov Vesselin T, Kobuley Dmytro, Tran Sara V, Bittinger Kyle, Bailey Aubrey G, Laughlin Alice L, Boucher Jean-Luc, Wherry E John, Bushman Frederic D, Allen Judith E, Virgin Herbert W: Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation. Science (New York, NY) 345 (6196): 578-82,2014.

Bewtra Meenakshi, Brensinger Colleen M, Tomov Vesselin T, Hoang Tram B, Sokach Carly E, Siegel Corey A: An optimized patient-reported ulcerative colitis disease activity measure derived from the Mayo score and the simple clinical colitis activity index. Inflammatory Bowel Diseases 20 (6): 1070-8,2014.

Tomov Vesselin T, Osborne Lisa C, Dolfi Douglas V, Sonnenberg Gregory F, Monticelli Laurel A, Mansfield Kathleen, Virgin Herbert W, Artis David: Persistent enteric murine norovirus infection is associated with functionally suboptimal virus-specific CD8 T cell responses. Journal of virology 87 (12): 7015-31,2013.

Vesselin T. Tomov, Lisa C. Osborne, Douglas V. Dolfi, Gregory F. Sonnenberg, Laurel A. Monticelli, Kathleen Mansfield, Herbert W. Virgin, David Artis: Persistent enteric murine norovirus infection is associated with functionally suboptimal virus-specific CD8 T cell responses American Association of Immunologists 2013 Annual Conference : 2013.

Vesselin T. Tomov, Olesya Palko, Lisa Osborne, Yuhang Sun, David Artis: Epitope-specific CD8 T cell subsets mediate protection against persistent murine norovirus infection Advances in Inflammatory Bowel Diseases 2013 Fellows Research Meeting : 2013.

Vesselin Tomov, Lisa Osborne, David Artis: Epitope-Specific T Cell Responses to Enteric Murine Norovirus Infection Center for Molecular Studies in Digestive and Liver Diseases at the University of Pennsylvania 2012 Symposium : 2012.

Vesselin Tomov, Lisa Osborne, Douglas Dolfi, Gregory Sonnenberg, Laurel Monticelli, David Artis: Epitope-Specific T cell Responses to Enteric Murine Norovirus (MNV) Infection University of Pennsylvania 2012 Immunology Graduate Group Retreat : 2012.

View all publications

Academic Contact Info

Division of Gastroenterology
421 Curie Boulevard
BRB II/III, Room 331 (lab) or Room 914 (office)

Philadelphia, PA 19104
Phone: (215) 531-1820
Patient appointments: 800-789-7366 (PENN)