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Vera P. Krymskaya, PhD, MBA, FCPP

Vera P. Krymskaya, PhD, MBA, FCPP Researcher

Professor of Medicine

Dr. Krymskaya is employed by Penn Medicine.

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Clinical Specialties


  • Pulmonary Medicine

Programs & Centers:

  • Heart and Vascular Research


American Thoracic Society, Respiratory Cell & Molecular Biology Assembly, International Institute for Regenerative Medicine, University of Pennsylvania Perelman School of Medicine, Local NIH Rare Diseases Clinical Research Network, International Orphan Disease Center, University of Pennsylvania, Local Penn Forum for Women Faculty, Local Scientific Advisory Board, Castleman's Disease Collaborative Network, International The College of Physicians of Philadelphia, National The Lymphangioleiomyomatosis (LAM) Foundation Scientific Advisory Board, International The National Disease Research Interchange, National Tuberous Sclerosis Complex Research Program, DOD Medical Research, International Tuberous Sclerosis Complex Research Program, International University of California Tobacco-Related Disease Research Program, Cancer-Basic Research Review Panel, National

Hospital Affiliation

Dr. Krymskaya is employed by Penn Medicine.


Description of Research Expertise:

Basic and translational research in rare and common lung diseases: pulmonary lymphangioleiomyomatosis (LAM), tuberous sclerosis (TS), Birt-Hogg-Dube (BHD); Multicentric Castleman Disease (MCD), pulmonary arterial hypertension (PAH), asthma; Cellular signaling networks: phosphatidylinositol 3-kinase (PI3K), Akt, tumor suppressor complex TSC1/TSC2, protein translational regulation, mTOR,LKB1, AMPK, FLCN, RhoA GTPase, Rac1 GTPase, STAT3; Airway smooth muscle cell biology and remodeling,vascular smooth muscle cell biology and remodeling, cell growth, cell proliferation, cell migration, invasiveness; animal models of lung diseases.

Selected Publications:

Elena A. Goncharova, Dmitry A. Goncharov, Melane L. James, Elena N. Atochina-Vasserman, Victoria Stepanova, Seung-Beom Hong, Hua Li, Linda Gonzales, Masaya Baba, W. Marston Linehan, Andrew Gow, Susan Margulies, Susan Guttentag, Laura S. Schmidt, and Vera P. Krymskaya: Folliculin Controls Lung Alveolar Enlargement and Epithelial Cell Survival through E-Cadherin, LKB1 and AMPK Cell Reports 7 (2): 412-423,2014.

Elena A. Goncharova, Dmitry A. Goncharov, Melane Fehrenbach, Irene Khavin, Blerina Ducka, Okio Hino, Thomas V. Colby, Mervyn J. Merrilees, Angela Haczku, Steven M. Albelda, and Vera P. Krymskaya: Prevention of Alveolar Destruction and Airspace Enlargement in a Mouse Model of Pulmonary Lymphangioleiomyomatosis (LAM) Science Translational Medicine 4 (154): 154ra134,2012.

Goncharova EA, Goncharov DA, Li H, Pimtong W, Lu S, Khavin I, Krymskaya VP: mTORC2 is required for proliferation and survival of TSC2-null cells Molecular and Cellular Biology 31 (12): 2484-98,2011.

Dmitry A. Goncharov, Tatiana Kudryashova, Houman Ziai, Kaori Ihida-Stansbury, Horace DeLisser, Vera P. Krymskaya, Rubin M. Tuder, Steven M. Kawut, Elena A. Goncharova: mTORC2 coordinates pulmonary artery smooth muscle cell metabolism, proliferation and survival in pulmonary arterial hypertension Circulation 129 (8): 864-874,2014.

Elena A. Goncharova, Dmitry A. Goncharov, and Vera P. Krymskaya: Tumor suppressors TSC1 and TSC2 differentially modulate actin cytoskeleton and motility of mouse embryonic fibroblasts The LAM Foundation 17th Annual International Conference : 48,2014.

Atochina-Vasserman EN, Guo CJ, Abramova E, Golden TN, Sims M, James ML, Beers MF, Gow AJ, Krymskaya VP: Surfactant Dysfunction and Lung Inflammation in the Female Mouse Model of Lymphangioleiomyomatosis American Journal of Respiratory Cell and Molecular Biology 53 (1): 96-104,2015.

Goncharova EA, Goncharov DA, Noonan D, Krymskaya VP: TSC2 modulates actin cytoskeleton and cell adhesion through TSC1-binding domain and the Rac1 GTPase Journal of Cell Biology 167 (6): 1171-1182,2004.

Goncharova EA, Goncharov DA, Eszterhas A, Hunter DS, Glassberg MK, Yeung RS, Walker CL, Noonan D, Kwiatkowski DJ, Chou MM, Panettieri RA Jr, Krymskaya VP: Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM) Journal of Biological Chemistry 277 (34): 30958-67,2002.

Stephen R. Hammes and Vera P. Krymskaya: Targeted Approaches Toward Understanding and Treating Pulmonary Lymphangioleiomyomatosis (LAM) Hormones and Cancer 4 (2): 70-7,2013.

Vera P. Krymskaya: Therapeutic Strategies for Treatment of Pulmonary Lymphangioleiomyomatosis (LAM) Expert Opinion on Orphan Drugs 2 (10): 1063-1074,2014.

View all publications

Academic Contact Info

219 Stemmler Hall
3450 Hamilton Walk

Philadelphia, PA 19104-6118
Phone: (215) 573-9861

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