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Ting-Chin David Shen, MD

Ting-Chin David Shen, MD Physician

Instructor A of Medicine

Dr. Shen is employed by Penn Medicine.

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Clinical Specialties


  • Gastroenterology

Programs & Centers:

Board Certification:

  • Gastroenterology, 2015
  • Internal Medicine, 2011

Description of Clinical Expertise

Abdominal Disorders
Abdominal Pain
Acid Peptic Disorders
Bowel Disorders
Gastroesophageal Reflux Disease (GERD)
Gastrointestinal Disorders
Irritable Bowel Syndrome
Peptic Ulcer Disease (Stomach Ulcers)

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Columbia University
Residency: NewYork-Presbyterian/Columbia University Medical Center
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania


American Gastroenterological Association, National

Hospital Affiliation

Dr. Shen is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Radnor: Has privileges to perform procedures.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

My research interests lie at the intersection of microbiology, immunology, and metabolism with a focus on the gut microbiome and liver diseases. Currently, I have projects that span the spectrum of basic, translational, and clinical research. These include: 1) Investigating the role of bacterial urease in host and microbial nitrogen flux and metabolism, 2) Determining the metabolome and proteome of cirrhotic ascites for the prevention and treatment of spontaneous bacterial peritonitis, and 3) Characterizing the gut microbiota as a precipitant of acute-on-chronic liver failure.

Selected Publications:

Friedman ES, Li Y, Shen TD, Jiang J, Chau L, Adorini L, Babakhani F, Edwards J, Shapiro D, Zhao C, Carr RM, Bittinger K, Li H, Wu GD: FXR-Dependent Modulation of the Human Small Intestinal Microbiome by the Bile Acid Derivative Obeticholic Acid Gastroenterology pii: S0016-5085(18) : 2018.

Shen TD, Pyrsopoulos N, Rustgi VK.: Microbiota and the Liver Liver Transplantation 24 (4): 539-550,2018.

Ni J, Shen TD, Chen EZ, Bittinger K, Bailey A, Roggiani M, Sirota-Madi A, Friedman ES, Chau L, Lin A, Nissim I, Scott J, Lauder A, Hoffman C, Rivas G, Albenberg A, Baldassano RN, Braun J, Xavier RJ, Clish CB, Yudkoff M, Li H, Goulian M, Bushman FD, Lewis JD, Wu GD.: A Role for Bacterial Urease in Crohn’s Disease and Gut Dysbiosis Science Translational Medicine 9 (416): 2017.

Shen TD: Diet and Gut Microbiota in Health and Disease Intestinal Microbiome: Functional Aspects in Health and Disease 88 : 117-126,2017.

Shen TD, Chehoud C, Ni J, Hsu E, Chen YY, Bailey A, Laughlin A, Bittinger K, Bushman FD, Wu GD.: Dietary Regulation of the Gut Microbiota Engineered by a Minimal Defined Bacterial Consortium PLOS ONE 11 (5): e0155620,2016.

Shen TD, Albenberg LA, Bittinger K, Chehoud C, Chen YY, Judge CA, Chau L, Ni J, Sheng M, Lin A, Wilkins BJ, Buza EL, Lewis JD, Daikhin Y, Nissim I, Yudkoff M, Bushman FD, Wu GD.: Engineering the Gut Microbiota to Treat Hyperammonemia Journal of Clinical Investigation 125 (7): 2841-50,2015.

Shen TD, Lebwohl B, Verma H, Kumta N, Tennyson C, Lewis S, Scherl E, Swaminath A, Capiak KM, DiGiacomo D, Bosworth BP, Brannagan TH 3rd, Green PH.: Peripheral neuropathic symptoms in celiac disease and inflammatory bowel disease Journal of Clinical Neuromuscular Disease 13 (3): 137-145,2012.

Shen T, Brannagan T, Tennyson C, Lewis S, Brannagan TH 3rd, Green PH: Prevalence of Peripheral Neuropathy in Celiac Disease Digestive Disease Week : 2010.

Shen TC, Guo S, Delgado E, Lee PG: Attending Physician and Medical Student Perception of Medical Jargon in Bedside Presentations Society of Hospital Medicine Annual Meeting : 2008.

Shen TC, Guo S, Delgado E, Lee PG: Attending Physician and Medical Student Perception of Medical Jargon in Bedside Presentations. 13th Annual American Medical Student Association Convention : 2008.

Academic Contact Info

421 Curie Boulevard
914 Biomedical Research Building II/III

Philadelphia, PA 19104
Patient appointments: 800-789-7366 (PENN)