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Samantha F. Butts, MD, MSCE

Samantha F. Butts, MD, MSCE Physician

Dr. Butts is employed by Penn Medicine.

About Dr. Samantha F. Butts

Recognized by America's Top Doctors 2015 – 2017

Recognized in Philadelphia magazine's annual Top Docs issues 2017 - 2019

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties


  • Reproductive Endocrinology and Infertility

Programs & Centers:

Board Certification:

  • Obstetrics and Gynecology - Reproductive Endocrinology/Infertility, 2009
  • Obstetrics and Gynecology, 2006

Clinical Expertise:

  • Amenorrhea
  • Anovulation
  • Anovulatory Bleeding
  • Assisted Reproductive Technology (ART)
  • Asthenospermia
  • Clomid
  • Congenital Uterine Anomaly
  • Diminished Ovarian Reserve
  • Egg Donation
  • Egg Retrieval
  • Embryo Transfer
  • Endometrioma
  • Endometriosis
  • Fertility Preservation
  • Fertility Problem
  • Fibroid Tumors Removal
  • Fluoroscopy
  • Gonadotropin Treatment
  • Hydrosalpinx
  • Hyperprolactinemia
  • Hysteroscopic Myomectomy
  • Hysteroscopy
  • In Vitro Fertilization (IVF)
  • Infertility
  • Intracytoplasmic Sperm Injection (ICSI)
  • Intrauterine Insemination (IUI)
  • Irregular Menstruation
  • Laparoscopic Myomectomy
  • Leiomyoma
  • Menstrual Disorders
  • Mullerian Anomalies (Müllerian Duct Anomalies)
  • Oligomenorrhea
  • Ovarian Failure
  • Ovarian Stimulation
  • Ovulation Induction
  • Polycystic Ovary Syndrome (PCOS)
  • Premature Menopause (Premature Ovarian Insufficiency)
  • Primary Ovarian Insufficiency
  • Recurrent Pregnancy Loss
  • Secondary Amenorrhea
  • Semen Analysis
  • Septate Uterus
  • Sperm Cryopreservation (Sperm Banking)
  • Surrogacy
  • Tubal Diseases
  • Tubal Factor Infertility
  • Unexplained Infertility
  • Uterine Abnormality
  • Uterine Fibroid Embolization Counseling
  • Uterine Fibroids (Leiomyomas)
  • Uterine Infertility
  • Uterine Myoma
  • Uterine Polyps (Endometrial Polyps)
  • Uterine Surgery
Show All Expertise

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oscar Health Plan of PA
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Harvard University
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania


American College of Obstetricians and Gynecologists, Fellow, National American Society for Reproductive Medicine, National Society for Reproductive Endocrinology and Infertility, National The Endocrine Society, National

Hospital Affiliation

Dr. Butts is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Environmental Reproductive Toxicology; Reproductive Health Disparities; Reproductive Senescence; In Utero Programming of Ovarian Function and Somatic Growth

Selected Publications:

Chan JL, Senapati S, Johnson LNC, DiGiovanni L, Voong C, Butts SF, Domchek SM.: Risk factors for sexual dysfunction in BRCA mutation carriers following risk-reducing salpingo-oophorectomy Menopause 26 (2): 132-139,2019.

Shaffer RM, Ferguson KK, Sheppard L, James-Todd J, Butts S, Chandrasekaran S, Swan SH, Barrett ES, Nguyen R, Bush N, McElrath TF, Sathyanarayana S: Maternal urinary phthalate metabolites in relation to gestational diabetes and glucose intolerance during pregnancy Environment International 123 : 588-596,2019.

Butts SF, Seifer DB, Koelper N, Senapati S, Sammel MD, Hoofnagle AN, Kelly A, Krawetz SA, Santoro N, Zhang H, Diamond M, Legro RS: Vitamin D deficiency is associated with poor ovarian stimulation outcome in PCOS but not unexplained infertility. Journal of Clinical Endocrinology and Metabolism 104 : 369-378,2019.

The Practice Committee of the American Society for Reproductive Medicine and Practice Committee of the Society for Assisted Reproductive Technology: Blastocyst culture and transfer in clinically assisted reproduction: a committee opinion Fertil Steril 110 (7): 1246-52,2018.

The Practice Committee of the American Society for Reproductive Medicine: Management of nonobstructive azoospermia: a committee opinion Fertil Steril 110 (7): 1239-45,2018.

The Practice Committee of the American Society for Reproductive Medicine: Current recommendations for vaccines for female infertility patients: a committee opinion Fertil Steril 110 (5): 838-41,2018.

Senapati S, Butts S, Koelper NC, Sammel MD, Seifer D, Legro S, Diamond M.: Vitamin D, First Trimester Human Chorionic Gonadotropin Kinetics, and Birthweight: Evidence for Hormonal Regulation of Fetal Growth In Women with Vitamin D Deficiency Accepted for oral presentation at the 2018 American Society for Reproductive Medicine Meeting : 2018.

Holder S, Koelper NC, Sammel MD, Barnhart KT, Butts S.: Barriers to Utilization of Gynecologic Services after Ectopic Pregnancy Poster presentation at the 2018 meeting of the American Society for Reproductive Medicine : 2018.

Butts SF, Koelper N, Sammel MD, Porterfield F, Seifer DB, Legro R: Response to Ovulation Induction in the Polycystic Ovary Syndrome (PCOS): The Role of Race Poster presentation at the 2018 Androgen Excess and PCOS Society annual meeting : 2018.

The Practice Committee of the American Society for Reproductive Medicine: Smoking and infertility: a committee opinion Fertil Steril 110 (4): 611-18,2018.

Academic Contact Info

Penn Fertility Care
Center for Reproductive Medicine and Surgery
University of Pennsylvania Medical Center
3701 Market Street, 8th Floor

Philadelphia, PA 19104
Phone: (215) 662-2975
Patient appointments: 800-789-7366

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