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Saif Anwaruddin, MD

Saif Anwaruddin, MD Physician

Co-Director, Transcatheter Valve Program Assistant Professor of Medicine at the Hospital of the University of Pennsylvania

Dr. Anwaruddin is a Penn Medicine employed physician.

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Clinical Specialties


  • Cardiology

Programs & Centers:

Board Certification:

  • Cardiovascular Disease, 2008
  • Interventional Cardiology, 2009

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Massachusetts
Residency: Massachusetts General Hospital
Fellowship: Clinical Clinic Foundation
Fellowship: Cleveland Clinic Foundation


American College of Cardiology, National American College of Cardiology, National American College of Physicians, National Massachusetts Medical Society, Local Society for Cardiac Angiography and Intervention (SCAI) , National Society for Cardiac Angiography and Interventions, International Worcester District Medical Society, Local

Hospital Affiliation

Dr. Anwaruddin is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.


Selected Publications:

Small A, Kiss D, Giri J, Anwaruddin S, Siddiqi H, Guerraty M, Chirinos J, Ferrari G, Rader DJ: Biomarkers of Calcific Aortic Disease. Arterioscler Thromb Vasc Biol. : 2017.

Fiorilli PN, Anwaruddin S: How Do We Treat Complex Calcified Coronary Artery Disease. Curr Treat Options Cardiovasc Med. 18 (12): 72,2016.

Ramee S, Anwaruddin S, Kumar G, Piana RN, Babaliaros V, Rab ST, Klein LW.: The Rationale for Performance of Coronary Angiography and Stenting Prior to Transcatheter Aortic Valve Replacement: From the Interventional Section Leadership Council of the American College of Cardiology. JACC Cardiovasc Interv 9 (23): 2371-2375,2016.

Anwaruddin S, Kirtane AJ, Thourani VH, Vemulapalli S, Manandhar P, Desai ND, Herrmann HC, Jagasia D, Bavaria JE, Giri J, Vallabhajosyula P, McCarthy FH, and Szeto WY.: Characterizing the Incidence and Predictors of Paravalvular Regurgitation After Transcatheter Aortic Valve Replacement (TAVR) and Its Impact on Outcomes: A Study of the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapies (STS/ACC TVT) Registry. Presented at the Transcatheter Cardiovascular Therapeutics (TCT). Washington DC. J Am Coll Cardiol. : 2016.

Rene AG, Jagasia D, Wickramasinghe SR, Desai N, Szeto W, Vallbhajosyula P, Li RH, Silvestry FH, Giri J, Jha S, Herrmann HC, Anwaruddin S: New Ventricular Septal Defects Following Balloon-Expandable Transcatheter Aortic Valve Replacement. J Invasive Cardiol. 28 (7): E59-65,2016.

Herrmann HC, Thourani VH, Kodali SK, Makkar RR, Szeto WY, Anwaruddin S, Desai N, Lim S, Malaisrie SC, Kereiakes DJ, Ramee S, Greason KL, Kapadia S, Babaliaros V, Hahn RT, Pibarot P, Weissman NJ, Leipsic J, Whisenant BK, Webb JG, Mack MJ, Leon MB: One-Year Clinical Outcomes with SAPIEN 3 Transcatheter Aortic Valve Replacement in High-Risk and Inoperable Patients with Severe Aortic Stenosis. Circulation 134 (2): 130-40,2016.

Szerlip M, Kim RJ, Adeniyi T, Thourani V, Babaliaros V, Bavaria J, Herrmann HC, Anwaruddin S, Makkar R, Chakravarty T, Rovin J, Creighton D, Miller DC, Baio K, Walsh E, Katinic J, Letterer R, Trautman L, Herbert M, Farkas R, Rudolph J, Brown D, Holper EM, Mack M.: The outcomes of transcatheter aortic valve replacement in a cohort of patients with end-stage renal disease. Catheter Cardiovasc Interv. 87 (7): 1314-21,2016.

Seto AH, Jordan Safirstein, Anwaruddin S, Dehghani P, Shah B, Tremmel JA: Late breaking trials of 2015 in coronary artery disease: Commentary covering ACC, EuroPCR, SCAI, TCT, ESC, and AHA. Catheter Cardiovasc Interv. 87 (7): 1224-30,2016.

Hyman M, Vemulapalli S, Szeto WY, Stebbins A, Patel P, Matsuoka R, Herrmann HC, Anwaruddin S, Desai ND, Vallabhajosyula P, Li R, Bavarai JE, Giri J.: Moderate vs. General Anesthesia for Transcatheter Aortic Valve Replacement: An STS/ACC Transcatheter Valve Therapy Registry Analysis. Presented as a Late Breaking Clinical Trial at the Society for Cardiovascular Angiography and Interventions (SCAI). Orlando, FL. : 2016.

Chen J, Nawaz N, Fox Z, Komlo C, Anwaruddin S, Desai N, Jagasia D, Herrmann HC, Han Y: Echocardiographic determinants of LV functional improvement after transcatheter aortic valve replacement. Catheter Cardiovasc Interv. 87 (6): 1164-72,2016.

Academic Contact Info

Hospital of the University of Pennsylvania
Perelman Center for Advanced Medicine
11th Floor - South Tower
34th Civic Center Boulevard

Philadelphia, PA 19104
Phone: 215-615-4333
Patient appointments: 800-789-7366 (PENN)