Description of Research Expertise:
Translational and basic science research in liver metabolic diseases including non-alcoholic and alcoholic fatty liver disease, focusing on the pathologic role of lipids and lipid associated proteins.
Williams B, Correnti J, Oranu A, Lin A, Scott V, Annoh M, Beck J, Furth E, Mitchell V, Senkal C, Obeid L: A novel role for ceramide synthase 6 in mouse and human alcoholic steatosis FASEB Journal : 2017.
Carr: In NAFLD, you are what you eat, not simply how much you eat Cellular and Molecular Gastroenterology and Hepatology 4 (2): 301–302,2017.
Falk, G; Ginsberg, G; Katzka, D; Carr, RM; Hamilton, K; Wu: Presentation of the Julius M. Friedenwald Medal to Anil K. Rustgi Gastroenterology : 2017.
Shubert: New Study: Unsaturated Fat Associated with Fatty Liver Disease
CMGH researchers report on the role of macronutrients in the development of metabolically unhealthy obesity.
Carr RM, Dhir R, Mahadev K, Comerford M, Chalasani NP: Perilipin Staining Distinguishes Between Steatosis and Nonalcoholic Steatohepatitis in Adults and Children Clin Gastroenterol Hepatol 15 (1): 145-47,2017.
Carr RM, *, Patel A *, Bownik H, Oranu A, Kerner C, Praestgaard A, Forde KA, K. Reddy KR: Intestinal Inflammation Does Not Predict Non-alcoholic fatty liver disease Severity in Inflammatory Bowel Disease Patients Digestive Diseases and Sciences 62 (5): 1354-1361.,2017.
Amanke Oranu, MD, Victoria Mitchell, Victoria Scott, Bianca Williams, Jason Correnti, Ph.D., and Rotonya Carr: Chronic alcohol consumption upregulates ceramide synthase 6 in hepatic lipid droplets and zone 3 hepatocytes of mice and humans
AASLD 2017 : 2017.
Alexis Ogdie, Sungat K. Grewal, Megan H. Noe, Daniel B. Shin, Junko Takeshita, Zelma C. Chiesa Fuxench, Rotonya M. Carr: Risk of incident liver disease in patients with psoriasis, psoriatic arthritis, and rheumatoid arthritis: a population-based study. Journal of Investigative Dermatology : 2017.
Quezada: Diversity in GI Training: A Timely Goal The New Gastroenterologist : 2017.
Roland Li, MD; Marina Serper, MD, MS; Vandana Khungar, MD, MSc; Amy Praestgaard, MS and Rotonya M. Carr: Impact of race/ethnicity and primary admission diagnosis on readmission and mortality rates among patients hospitalized with hepatic encephalopathy
AASLD 2017 : 2017.
Oranu, A; Williams, B; Correnti, J; Scott, V; Mitchell, V.; and Carr: Absence of Perilipin 2 prevents the increase of long-chain ceramides in the lipid droplet fractions of alcohol-fed mice Gordon Research Conference : 2017.
Oranu,A; Lin,A.; Williams: Absence of Perilipin 2 prevents the increase of long-chain ceramides in the lipid droplet fractions of alcohol-fed mice
Hepatology 64 (S1): 2016.
Williams,B; Correnti,J, Oranu,A; Lin,A; Beck, J. and Carr: Ceramide Synthase May Regulate Hepatic Perilipin 2 and Lipid Metabolism in Experimental Alcoholic Steatosis FASEB Lipid Droplets: Dynamic Organelles in Metabolism and Beyond Conference : 2016.
Carr, RM; Oranu, A; Khungar: Non-alcoholic fatty liver disease: Pathogenesis and Current Management Clinics in Gastroenterology 45 (4): 2016.
Williams B, Correnti J: Ceramide Synthase May Regulate Hepatic Perilipin 2 and Lipid Metabolism in Experimental Alcoholic Steatosis AASLD Conference : 2015.
Kupfer SS, Carr RM: Reducing colorectal cancer risk among African-Americans Gastroenterology 149 (6): 1302-4,2015.
Carr: Pathogenesis of Lipid Droplet Proteins in Liver Diseases Experimental Cell Research 340(2):187-92. : 2016.
Correnti, J; Williams, B; Gottshall, L; and Carr: Oleate, palmitate and C2 ceramide differentially impact lipid oxidation and trafficking in alcohol-treated human hepatoma cells Gordon conference : 2015.
Carr: It’s lucky we found it. In E. Armstrong, M. Fischer, R Parsa-Parsi, and M. Wetzel (Eds.), The Health Care Dilemma: A Comparison of Health Care Systems in Three European Countries and the US (324-331). Singapore: World Scientific Publishing Co. The Health Care Dilemma: A Comparison of Health Care Systems in Three European Countries and the US (324-331). Singapore: World Scientific Publishing Co. : 2011.
Carr RM, Mohrman L, Arelli V: Update on Cause and Management of Catscratch Disease Infections in Medicine 25 (5): 242-250,2008.
Carr, RM, Correnti: Insulin resistance in clinical and experimental alcoholic liver disease Ann N Y Acad Sci 1353 : 1-20,2015.
Carr, RM and Reid: FXR agonists as Therapeutic Agents for Non-alcoholic Fatty Liver Disease Current Atherosclerosis Reports 17 (4): 2015.
Roland Li, Ann Tierney: The Impact of Peri-Discharge Interventions on 30-day Readmission and 90-day Mortality Rates for Patients Admitted with Hepatic Encephalopathy ACG National Meeting 2014 : 2014.
Carr RM, Peralta G, Yin X: Absence of Perilipin 2 Prevents Hepatic Steatosis, Glucose Intolerance and Ceramide Accumulation in Alcohol-fed Mice PLoS One 9 (5): e97118,2014.
Understanding the pathogenesis of insulin resistance in non-alcoholic and alcoholic liver diseases JSM Gastroenterology and Hepatology 1 : 1002,2013.
Carr RM, Patel A, Kerner C, Tierney A, Forde K: Metabolic syndrome, but not IBD severity, increases risk of NAFLD severity in patients with dual diagnosis of IBD and NAFLD American Association for the Study of Liver Diseases (AASLD) : 2013.
McConnell R: Headache with Hematochezia: A Case of Sumatriptan-Induced Ischemic Colitis
Digestive Disease Week : 2013.
Carr RM, Patel A, Kerner C, Tierney A, Forde K: Metabolic syndrome and IBD severity may increase risk of NAFLD Digestive Disease Week
Carr RM, Dhir R, Yin X, Agarwal B: Temporal effects of ethanol consumption on energy homeostasis, hepatic steatosis and insulin sensitivity in mice Alcohol Clin Exp Res 37 (7): 1091-9,2013.
Carr RM, Kalyankar M, Dhir R,Comerford M, Chalasani N: Differential expression of PLIN1 and PLIN2 in fatty liver diseases in adults and children IDOM : 2015.
"This study by Mathurin et al. not only calls into question the longstanding practice of..." Evaluation of: [Mathurin P et al. Early liver transplantation for severe alcoholic hepatitis. N Engl J Med. 2011 Nov 10; 365(19):1790-800; doi: 10.1056/NEJMoa1105703]. Faculty of 1000, 19 Dec 2011. F1000.com/13408982 Faculty of 1000 : 2011.
Carr RM, Patel R, Rao V, Graham M, Crooke R: Reduction of TIP47 improves hepatic steatosis and glucose homeostasis in diet-induced obese mice EASL : 2011.
Carr RM, Patel R, Rao V, Graham M, Crooke R: Reduction of TIP47 improves hepatic steatosis and glucose homeostasis in mice Am J Physiol Regul Integr Comp Physiol. 302 (8): R996-1003,2012.
Alas! Ileal interposition surgery for diabetes prevention? Gastroenterology 138 (7): 2437-46,2010.
Wolden-Hanson T, Mitton DR, McCants RL, Yellon SM, Wilkinson CW, Matsumoto AM: Daily melatonin administration to middle-aged male rats suppresses body weight, intraabdominal adiposity, and plasma leptin and insulin independent of food intake and total body fat. Endocrinology 141 (2): 487-97,2000.
Carr, Rotonya McCants and Lynch: At the crossroads in the management of gastroesophageal junction carcinomas-where do we go from here? Gastrointestinal cancer research : GCR 2 (5): 253-5,2008.
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